Littlewood, J. M. (1972). Archives of Disease in Childhood, 47, 218. 66 infants with urinary tract infection in first month of life. Sixty-six newborn infants with urinary tract infection are described. The wide variation in clinical manifestations is stressed and suggested as an explanation for the variety of clinical descriptions, incidence, and prognosis noted by previous authors. The condition commonly presents on the sixth or seventh day, there is no seasonal incidence, boys are affected more frequently than girls. There was a correlation with maternal infection, perinatal anoxia, and birthweight either below or above the normal range. Unsatisfactory weight progress, lethargy, and anorexia were the most frequent clinical signs. The overall mortality was 11 % and further infection occurred in 37% of girls and in 10% of the boys. A clinical classification for the condition is suggested.Though urinary tract infection is a relatively common occurrence in the first month of life (Craig, 1935;James, 1959;Lincoln and Winberg, 1964;O'Doherty, 1968; Littlewood, Kite, and Kite, 1969), there are few large series of such infants reported. Previous publications reveal a lack of general agreement as to the usual clinical picture to be expected, which is probably due to the fact that some authors are reporting infants clinically ill with urinary infection, together with other infants who have been detected when the condition is causing little clinical disturbance.In this paper a large series of infants with clinical illness attributed to urinary infection is reviewed. 59 infants were diagnosed as a result of investigation of their illness and 7 were detected during the course of a screening survey while relatively asymptomatic. 50 of the infants were examined personally by the author during the course of their initial illness and in addition to usual laboratory investigations, microscopy of a fresh specimen of uncentrifuged urine was carried out as further confirmation of the diagnosis.The term 'urinary tract infection' is used in preference to 'pyelonephritis', though renal parenchymal infection is certainly present in some of these infants, in others the differentiation between upper and lower urinary tract infection is not possible either by clinical or laboratory methods.
MethodsThe diagnosis of urinary tract infection was usually clear cut where urine was examined in the symptomatic infants, but quantitative cultures and urine white cell counts were performed only on later infants in the series. In earlier case, gross bacteriuria and pyuria were usually evident on microscopy and a heavy growth of the responsible organism obtained on culture. The diagnosis in 2 of the 7 asymptomatic infants was confirmed by suprapubic aspiration where the findings of voided urine were equivocal.
MothersMaternal infection. 450 of the mothers of infected infants were known to have had some type of infection or pyrexia during labour or in puerperium.Puerperal pyrexia. This (37 * 8°C) occurred in 300/o (18/60) of mothers whose infants ...