Urinary d-lactate excretion in infants with necrotizing enterocolitis

Garcia, Jose; Smith, Franklin R.; Cucinell, Samuel A.

doi:10.1016/s0022-3476(84)81010-0

Cited by 43 publications

(22 citation statements)

References 14 publications

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“…In the other subgroup, a high production of C6 (>6%) was detected and characterized the group with digestive disorders. This increase appeared before day 10 (Fig. 2).…”

Section: Frequency Of Teyrtporal Changes In Fecal Scfa Profilementioning

confidence: 75%

Fecal Short‐Chain Fatty Acids Predict Digestive Disorders in Premature Infants

Szylit¹,

Maurage

Gasqui

et al. 1998

J Parenter Enteral Nutr

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“…In the other subgroup, a high production of C6 (>6%) was detected and characterized the group with digestive disorders. This increase appeared before day 10 (Fig. 2).…”

Section: Frequency Of Teyrtporal Changes In Fecal Scfa Profilementioning

confidence: 75%

Fecal Short‐Chain Fatty Acids Predict Digestive Disorders in Premature Infants

Szylit¹,

Maurage

Gasqui

et al. 1998

J Parenter Enteral Nutr

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“…8 Furthermore, elevated lactate has been correlated to advanced disease in NEC. 9,10 However, most studies of markers in NEC only include small numbers of patients and therefore lack statistical power. 5,9,10 In the present study, we retrospectively evaluated clinical and laboratory parameters in a large cohort of infants presenting with NEC.…”

Section: Introductionmentioning

confidence: 99%

“…9,10 However, most studies of markers in NEC only include small numbers of patients and therefore lack statistical power. 5,9,10 In the present study, we retrospectively evaluated clinical and laboratory parameters in a large cohort of infants presenting with NEC. The primary aim was to determine the relationship between pre-intervention laboratory results (preoperative or before the decision to treat conservatively), disease severity (Bell stage 11 ), birth weight (BW) and gestational age (GA), and survival.…”

Section: Introductionmentioning

confidence: 99%

A simple presurgical necrotizing enterocolitis-mortality scoring system

et al. 2006

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Objective: To assess the relationship between early laboratory parameters, disease severity, type of management (surgical or conservative) and outcome in necrotizing enterocolitis (NEC). Study design:Retrospective collection and analysis of data from infants treated in a single tertiary care center (1980 to 2002). Data were collected on disease severity (Bell stage), birth weight (BW), gestational age (GA) and pre-intervention laboratory parameters (leukocyte and platelet counts, hemoglobin, lactate, C-reactive protein).Results: Data from 128 infants were sufficient for analysis. Factors significantly associated with survival were Bell stage (P<0.05), lactate (P<0.05), BW and GA (P<0.01, P<0.001, respectively). From receiver operating characteristics curves, the highest predictive value resulted from a score with 0 to 8 points combining BW, Bell stage, lactate and platelet count (P<0.001). At a cutoff level of 4.5 sensitivity and specificity for predicting survival were 0.71 and 0.72, respectively.Conclusion: Some single parameters were associated with poor outcome in NEC. Optimal risk stratification was achieved by combining several parameters in a score.

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“…The most important of these are the short chain organic acids, derived in the process of fermentation of undigested dietary carbohydrate. 46 These irritants initiate an inflammatory process at the level of the mucosal surface by disrupting epithelial cells and stimulating the underlying mast cells into action. Systemic neutrophils, eosinophils and macrophages are recruited.…”

Section: Intestinal Inflammationmentioning

confidence: 99%

Development of Gastrointestinal Function: Risk Factors for Necrotizing Enterocolitis

Clark

Mitchell

2004

The Journal of Pediatric Pharmacology and Therapeutics

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REVIEW ARTICLEThe intestinal tract of the fetus matures rapidly in the third trimester of the pregnancy. The premature infant has decreased intestinal motility, limited digestion, absorption and excretion, and poor intestinal barrier defense. These limitations place the infant at high risk for acute intestinal injury, necrotizing enterocolitis. This article reviews the development of the gastrointestinal tract in the fetus, the barriers to feeding the high risk, premature infant, and the most serious intestinal disease, necrotizing enterocolitis.

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Urinary d-lactate excretion in infants with necrotizing enterocolitis

Cited by 43 publications

References 14 publications

Fecal Short‐Chain Fatty Acids Predict Digestive Disorders in Premature Infants

Fecal Short‐Chain Fatty Acids Predict Digestive Disorders in Premature Infants

A simple presurgical necrotizing enterocolitis-mortality scoring system

Development of Gastrointestinal Function: Risk Factors for Necrotizing Enterocolitis

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