Urinary cystatin C: pediatric reference intervals and comparative assessment as a biomarker of renal injury among children in the regions with high burden of CKDu in Sri Lanka

Systematic Review of Kidney Injury Biomarkers for the Evaluation of CKD of Uncertain Etiology

“…In the setting of kidney disease, impaired proximal tubular catabolism of CysC can lead to elevated urinary concentrations. Several studies have measured urinary CysC in CKDu, 30 , 36 , 67 including 1 pediatric study which sought to establish reference intervals in healthy Sri Lankan children. 67 In a study of Sri Lankan adults, urinary CysC was unable to distinguish between cases of CKDu and nonendemic CKD (ROC-AUC, 0.585) ( n = 160).…”

“…Several studies have measured urinary CysC in CKDu, 30 , 36 , 67 including 1 pediatric study which sought to establish reference intervals in healthy Sri Lankan children. 67 In a study of Sri Lankan adults, urinary CysC was unable to distinguish between cases of CKDu and nonendemic CKD (ROC-AUC, 0.585) ( n = 160). 30 In women living in San Luis Potosí, Mexico, urinary CysC was weakly correlated to serum aflatoxin concentration (AFB 1 -Lysine) ( n = 34).…”

“…Ped Neph 39 Sri Lanka 922 total adolescents Urinary KIM-1 Yes Cusabio Technology ELISA (KIM-1 and NGAL) Early morning void 677 controls Urinary NGAL 54.7% female Sandamini et al. World J Ped , 2022 67 Sri Lanka 892 total adolescents Urinary Cystatin c Yes Cusabio CSB-E08384h (Cystatin c) UACR First morning void 471 controls 52.9% female Ramirez-Rubio et al. NDT , 2016 42 Nicaragua 200 total adolescents Urinary NGAL Yes Bioporto ELISA (NGAL), MBL ELISA (IL-18), Roche colorimetric assay (NAG) Random spot urine.…”