Urinary copper losses in infants receiving free amino acid solutions

Tyrala, Eileen E.; Brodsky, Nancy L.; Auerbach, Victor H.

doi:10.1093/ajcn/35.3.542

Cited by 32 publications

(16 citation statements)

References 11 publications

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“…Eighty percent of copper is excreted in the bile and the remainder is excreted in the urine [8]. In the context of PN, copper may have increased urinary excretion, as copper is complexed to amino acids [9]. …”

Section: Trace Elementsmentioning

confidence: 99%

Trace Elements in Parenteral Nutrition: Considerations for the Prescribing Clinician

2017

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Trace elements (TEs) are an essential component of parenteral nutrition (PN). Over the last few decades, there has been increased experience with PN, and with this knowledge more information about the management of trace elements has become available. There is increasing awareness of the effects of deficiencies and toxicities of certain trace elements. Despite this heightened awareness, much is still unknown in terms of trace element monitoring, the accuracy of different assays, and current TE contamination of solutions. The supplementation of TEs is a complex and important part of the PN prescription. Understanding the role of different disease states and the need for reduced or increased doses is essential. Given the heterogeneity of the PN patients, supplementation should be individualized.

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Section: Trace Elementsmentioning

confidence: 99%

Trace Elements in Parenteral Nutrition: Considerations for the Prescribing Clinician

2017

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“…pH was adjusted by 0.1 M HNO 3 , and solutions were heated for boiling on a hot plate for 10 min to decompose the metal complexes. Sample taken from electrolytic process was treated by 1 M HNO 3 and heated for metal complexes decomposition, with ought previous preparation. The solution was quantitatively transferred to 100 mL volumetric flask and completed to the mark with DDW water.…”

Section: Electrode Preparationmentioning

confidence: 99%

A Copper(II) Ion‐Selective Potentiometric Sensor Based on N,N′,N″,N′′′‐Tetrakis(2‐pyridylmethyl)‐1,4,8,11‐tetraazacyclotetradecane in PVC Matrix

Petković¹,

Sovilj

Budimir³

et al. 2010

Electroanalysis

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The simple PVC-based membrane containing N,N',N'',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc) as an ionophore and dibutyl phthalate as a plasticizer, directly coated on a glassy carbon electrode was examined as a new sensor for Cu 2þ ions. The potential response was linear within the concentration range of 1.0 Â 10 À1 -1.0 Â 10 À6 M with a Nernstian slope of 28.8 mV/decade and detection limit of 7.0 Â 10 À7 M. The electrode was used in aqueous solutions over a wide pH range (1.3 -6). The sensor exhibited excellent selectivity for Cu 2þ ion over a number of cations and was successfully used in its determination in real samples.

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“…Amino acid bound metals may account for most of the urinary metals, as has been reported for zinc . Urinary copper losses of infants receiving free amino acid solutions intravenously have been reported to correlate positively with total excretion of ~t-amino nitrogen and the excretion of glycine, methionine, histidine and lysine (Tyrala et al, 1982). Amino acid absorption may be more rapid from peptides and L-amino acid mixes than from whole proteins.…”

Section: Increased Urinary Lossmentioning

confidence: 99%

Problems related to diet management of maternal phenylketonuria

Acosta

Stepnick-Gropper

1986

J of Inher Metab Disea

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Provision of nutritionally complete elemental diets for pregnant women with PKU requires greater knowledge of 'conditionally' essential nutrient requirements than is presently available as well as application of known information. Formulation of elemental products needs to be improved to enhance aroma and taste and to decrease osmolality. Designers of the metal and vitamin components should keep in mind that a major portion (70-80%) of most of these nutrients must be obtained from the elemental products. Thus deletion of suspected essential minerals or vitamins could cause serious deficiencies. On the other hand, knowledge of appropriate ratios that make for improved trace metal absorption should be applied. Clinical nutritionists need to assist patients in selection of foods that are low in binding substances and provide 'conditionally' essential nutrients in adequate amounts. Closer cooperation between clinical nutritionists, nutrition scientists and food technologists should result in improved elemental products for care of pregnant women with PKU.

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Urinary copper losses in infants receiving free amino acid solutions

Cited by 32 publications

References 11 publications

Trace Elements in Parenteral Nutrition: Considerations for the Prescribing Clinician

Trace Elements in Parenteral Nutrition: Considerations for the Prescribing Clinician

A Copper(II) Ion‐Selective Potentiometric Sensor Based on N,N′,N″,N′′′‐Tetrakis(2‐pyridylmethyl)‐1,4,8,11‐tetraazacyclotetradecane in PVC Matrix

Problems related to diet management of maternal phenylketonuria

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