Urinary concentrations of phenols and phthalate metabolites reflect extracellular vesicle microRNA expression in follicular fluid

Martinez, Rosie M.; Hauser, Russ; Liang, Liming; Mansur, Abdallah; Adir, Michal; Dioni, Laura; Racowsky, Catherine; Bollati, Valentina; Baccarelli, Andrea A.; Machtinger, Ronit

doi:10.1016/j.envint.2018.11.043

Cited by 43 publications

(15 citation statements)

References 79 publications

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“…62 Such activity will lead to the attack of somatic and granula cells, interfering directly in folliculogenesis, leading to poor follicular development both in vivo and in vitro. 63 The current consensus for treatments of some types of localized CA involves the provision of AR regardless of the use of chemotherapy. 64 However, in the present review, no articles were found using radiotherapy alone as a treatment choice.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic Activity of Antineoplastic Agents on Fertility: A Systematic Review

Moura

Monteiro

2020

Rev Bras Ginecol Obstet

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Objective To analyze the long-term effects of antineoplastic treatments on patient fertility. Selection of Studies The studies were selected through the New PubMed, Scielo and Lilacs databases along with references used for the creation of the present work. For the selection of studies, articles published between the periods from January 1, 2015 to April 6, 2020 in the English, Portuguese and Spanish languages were used. As inclusion criteria: cohort studies and studies conducted in vitro. As exclusion criteria: review articles, reported cases, studies that do not address thematic reproduction, studies that do not address the cancer theme, articles that used animals, articles that address the preservation of fertility and articles in duplicate in the bases. Data Collection The collected data included: age of the patient at the beginning of treatment, type of neoplasm, type of antineoplastic treatment, chemotherapy used, radiotherapy dosage, radiotherapy site, effect of antineoplastic agents on fertility and number of patients in the study. Data Synthesis Thirty studies were evaluated, antineoplastic chemotherapy agents and radiotherapy modulate serum hormone levels, reduces germ cell quantities and correlated with an increase in sterility rates. The effects mentioned occur in patients in the prepubertal and postpubertal age. Conclusion Antineoplastic treatments have cytotoxic effects on the germ cells leading to hormonal modulation, and pubertal status does not interfere with the cytotoxic action of therapies.

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Section: Discussionmentioning

confidence: 99%

Cytotoxic Activity of Antineoplastic Agents on Fertility: A Systematic Review

Moura

Monteiro

2020

Rev Bras Ginecol Obstet

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“…In brief, this method starts with the digestion of proteins in the mixture; the resulting peptides are separated by liquid chromatography (LC) and identified by tandem mass spectrometry (MS). Equivalent DEHP exposure was measured as previously described ( 23 ). The summary DEHP (ΣDEHP) metabolite measurement was calculated based on the molar sum of MEHP, MEOHP, MEHHP, and MECPP, according to the following formula:…”

Section: Methodsmentioning

confidence: 99%

Mono-(2-ethylhexyl) phthalate Promotes Dengue Virus Infection by Decreasing IL-23-Mediated Antiviral Responses

et al. 2021

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Exposure to environmental hormones such as di(2-ethylhexyl) phthalate (DEHP) has become a critical human health issue globally. This study aimed to investigate the correlations between DEHP/mono-(2-ethylhexyl) phthalate (MEHP) levels and macrophage-associated immune responses and clinical manifestations in dengue virus (DV)-infected patients. Among 89 DV-infected patients, those with DV infection-related gastrointestinal (GI) bleeding (n = 13, 15% of patients) had significantly higher DEHP exposure than those without GI bleeding (n = 76, 85% of patients), which were 114.2 ng/ml versus 52.5 ng/ml ΣDEHP in urine; p = 0.023). In an in vitro study using cultured human monocyte-derived macrophages (MDMs) to investigate the effects of MEHP, treatment increased IL-1β and TNF-α release but decreased IL-23 release, with negative correlations observed between urine ΣDEHP and serum IL-23 levels in patients. MEHP-treated MDMs had lower antiviral Th17 response induction activity in mixed T-cell response tests. The in vitro data showed that MEHP increased DV viral load and decreased IL-23 release dose-dependently, and adding IL-23 to MEHP-exposed MDMs significantly reduced the DV viral load. MEHP also suppressed IL-23 expression via the peroxisome proliferator-activated receptor-gamma (PPAR-γ) pathway. Further, the PPAR-γ antagonist GW9662 significantly reversed MEHP-induced IL-23 suppression and reduced the DV viral load. These study findings help to explain the associations between high MEHP levels and the high global burden of dengue disease.

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“…Further studies should be carried out to explore biological features of this crosstalk to fully understand pathogenesis and mechanism of disease associated with this network. Martinez et al (2019) detected expression of 133 miRNAs in extracellular vesicles among more than 50% follicular fluid samples to mediate intracellular communication (Li, Zheng, et al, 2015) and regulate oocyte maturation. Recent research works found extensive expression of circRNAs in exosomes (Lasda & Parker, 2016), implying their vital role in early diagnosis of diseases.…”

Section: Future Expectationmentioning

confidence: 99%

Circular RNAs: Novel potential regulators in embryogenesis, female infertility, and pregnancy‐related diseases

Gao

Wang

Pan

et al. 2021

Journal Cellular Physiology

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Circular RNAs (circRNAs) are endogenous noncoding RNAs with unique cyclic structures. Although they were previously considered as nonfunctional transcription byproducts, numerous studies have demonstrated that circRNAs regulate gene transcription and expression via different mechanisms. Reproductive health influences the quality of life and affects offspring propagation in women. CircRNAs have been found to modify pregnancy‐related diseases, gynecologic cancers, polycystic ovary syndrome, aging, gamete, and embryo development. It's promising for circRNAs to be the novel diagnostic and therapeutic targets for multiple reproductive diseases. With the widespread application of assisted reproduction technology (ART), it has been revealed that circRNA identification contributes to estimating the quality of gametes and embryos, reflecting the success rate of ART. CRISPR‐Cas9 gene editing technology has enabled the discovery of new roles of circRNAs. So far, the roles of circRNAs in the reproductive system remain poorly defined. In this review, we describe the classification and functions of circRNAs in embryogenesis and the female reproductive system diseases, revealing potential roles of circRNAs physiologically and pathologically. In so‐doing, we provide ideas for developing circRNA‐based therapeutic treatment and clinical application of various female reproductive system diseases.

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Urinary concentrations of phenols and phthalate metabolites reflect extracellular vesicle microRNA expression in follicular fluid

Cited by 43 publications

References 79 publications

Cytotoxic Activity of Antineoplastic Agents on Fertility: A Systematic Review

Cytotoxic Activity of Antineoplastic Agents on Fertility: A Systematic Review

Mono-(2-ethylhexyl) phthalate Promotes Dengue Virus Infection by Decreasing IL-23-Mediated Antiviral Responses

Circular RNAs: Novel potential regulators in embryogenesis, female infertility, and pregnancy‐related diseases

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