Urinary concentrations of benzophenone-type UV filters and semen quality

Louis, Germaine M. Buck; Chen, Z.; Kim, S.; Sapra, Katherine J.; Bae, Jisuk; Kannan, Kasthuri

doi:10.1016/j.fertnstert.2014.07.310

Cited by 6 publications

(4 citation statements)

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“…7 Timeto-pregnancy (TTP), defined as the number of menstrual cycles or months of unprotected intercourse required to achieve pregnancy, is a sensitive couple-mediated endpoint for assessing reproductive toxicity and has been used to evaluate both persistent 8 and shortlived chemicals. 9,10 As TTP is couple-dependent, potentially toxic exposures should be measured in both male and female partners to potentially avoid erroneous conclusions based upon a single partner; ideally, biological samples would be obtained from both partners to measure toxicant concentrations (eg, blood metal concentrations) associated with more readily measured behaviors (eg, self-reported tobacco product use). 8 Despite the need for couple-mediated endpoints in assessing reproductive toxicity, the existing literature on reproductive (nonobstetric) toxicity of smokeless tobacco comprises exclusively studies of semen quality, a male-specific endpoint.…”

Section: Introductionmentioning

confidence: 99%

Time-to-Pregnancy Associated With Couples’ Use of Tobacco Products

Sapra

Barr

Maisog

et al. 2016

NICTOB

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Introduction: Previous studies suggest female smoking increases time-to-pregnancy (TTP), a couple-dependent reproductive outcome, while associations with male smoking are more ambiguous. Furthermore, despite small increases in smokeless tobacco use in the United States, no prior study has evaluated TTP among smokeless tobacco users. Methods: Using population-based sampling in 16 counties in Michigan and Texas, 501 couples discontinuing contraception to become pregnant were followed until positive pregnancy test or 12 months of trying. Participants were interviewed on lifetime and current cigarette, cigar, and chew/snuff (smokeless) use and provided blood samples for quantification of heavy metals and cotinine. Fecundability odds ratios (FORs) and 95% confidence intervals (95% CIs) were estimated, adjusted for demographics/lifestyle. FORs less than 1 reflect longer TTP. Results: Eleven percentage of females and 15% of males smoked cigarettes. Among men, 14% smoked cigars, 9% used snuff, and 2% used chew. Compared with never tobacco users, male (FOR: 0.41, 95% CI: 0.24, 0.68) and female (FOR: 0.53, 95% CI: 0.33, 0.85) smoking were individually associated with longer TTP; males' smoking remained significant (FOR: 0.46, 95% CI: 0.27, 0.79) when modeling partners together. Cadmium levels were higher in smokers than smokeless tobacco and never users; adjusting for cadmium attenuated the cigarette-TTP association, particularly among women. TTP was shorter among smokeless tobacco users relative to smokers (FOR: 2.86, 95% CI: 1.47, 5.57). Conclusions: Compared with never users, smokeless tobacco did not alter TTP in our cohort; however, TTP was shorter compared with smokers. We observed longer TTP in male and female smokers; cadmium may partially contribute. Implications: Both partners' preconception smoking contributed to longer TTP, highlighting the importance of both partners' lifestyles in healthy reproduction and underscores the need for couple-based preconception guidance. The male's contribution is a new finding. Higher cadmium levels may partially contribute to longer TTP in smokers, particularly among females. Though we do not observe longer TTP among a small sample of smokeless tobacco users compared with never tobacco users, we observe shorter TTP compared with smokers. Further work is needed to more thoroughly delineate the relationship between smokeless tobacco use and TTP and possible mechanisms of tobacco use's effects on reproduction.

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Section: Introductionmentioning

confidence: 99%

Time-to-Pregnancy Associated With Couples’ Use of Tobacco Products

Sapra

Barr

Maisog

et al. 2016

NICTOB

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“…Benzophenones are used as ultraviolet light filters in sunscreens and personal care products. 109 Only a few studies have so far evaluated the associations between urinary and seminal benzophenone levels. Some of them have suggested a negative association of urinary or seminal benzophenone levels with sperm concentration and sperm motility.…”

Section: Nonpersistent Chemicalsmentioning

confidence: 99%

“…Some of them have suggested a negative association of urinary or seminal benzophenone levels with sperm concentration and sperm motility. 96,107,109,110 In addition to the above-mentioned personal care products and pharmaceuticals, phthalates are also used as plasticizers in plastic products. 111 Multiple studies have shown a negative association between urinary and seminal levels of phthalate metabolites and both sperm concentration and motility.…”

Section: Nonpersistent Chemicalsmentioning

confidence: 99%

Deteriorating Semen Quality: The Role of the Environment

Virtanen,

Rodprasert,

Toppari

2023

Semin Reprod Med

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Since the end of the last century, several reports have suggested that semen quality is declining, especially in Western countries. Furthermore, cross-sectional studies using similar protocols have suggested regional differences in semen quality of young and fertile men. Reasons for these regional differences and local adverse trends in semen quality are unknown, but environmental factors are suspected to have a role. Besides adulthood environmental exposures, those occurring during testicular development may also affect semen quality. Longitudinal follow-up studies and mixture risk analyses are needed to study the effect of fetal, childhood, and adult life environment on semen quality.

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“…They suggest that further research is needed in other male populations. When the relationship between semen parameters and reproductive hormones is evaluated in other studies with BP-type UV filters, it is reported that there is a significant relationship [79] and found no association between urinary concentrations of BP3 and idiopathic male infertility [80]. As a result, human exposure to these organic UV filters can interfere with sperm and impair fertility.…”

Section: Cosmetics (Uv Filters)mentioning

confidence: 99%

Endocrine Disruptors and Infertility

Yazar¹

2022

The Toxicity of Environmental Pollutants

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Endocrine-disrupting chemicals (EDC) are known to interfere the body’s endocrine system. EDCs can also be considered as industrial chemicals namely pesticides, cleaning materials, plastics, heavy metals, and cosmetics. Most of these compounds particularly at low doses, occurring in complex mixtures, have been reported as emerging contaminants. EDCs are currently present in environment (water, diet, food contact materials, personal care products, etc). The adverse effects of exposure to EDCs have already been extensively described such as infertility, cancers, disrupted thyroid function, neurological disorders, obesity, metabolic syndrome. EDCs may be blamed for increasing the human reproductive disorders especially infertility. This is a serious public health problem that should not be ignored. This chapter aims to summarize the major scientific advances in human infertility associated with exposure to EDCs with epidemiological and experimental evidence. The chemicals covered in this chapter are heavy metals (lead), pesticides (pyrethroids), and cosmetics (UV filters).

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Urinary concentrations of benzophenone-type UV filters and semen quality

Cited by 6 publications

References 0 publications

Time-to-Pregnancy Associated With Couples’ Use of Tobacco Products

Time-to-Pregnancy Associated With Couples’ Use of Tobacco Products

Deteriorating Semen Quality: The Role of the Environment

Endocrine Disruptors and Infertility

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