Urinary Concentrations of Benzophenone-Type Ultraviolet Radiation Filters and Couples' Fecundity

Louis, Germaine M. Buck; Kannan, Kurunthachalam; Sapra, Katherine J.; Maisog, José M.; Sundaram, Rajeshwari

doi:10.1093/aje/kwu285

Cited by 85 publications

(30 citation statements)

References 39 publications

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“…We are aware of one previous paper reporting that BP-3 can be detected and quantified in semen (37). In our previous paper focusing on these same five BP-type UV filters as measured in both partners of the couples participating in the LIFE Study, we found that male partners’ BP-2 concentrations were associated with a significant 31% reduction in couple fecundity resulting in a longer time-to-pregnancy even after adjusting for the female partners concentrations (18). While speculative, it remains possible that BP-2 may account for the longer observed time-to-pregnancy, perhaps through subtle alterations in semen endpoints.…”

Section: Discussionmentioning

confidence: 90%

“…A recent paper reported that BP-1 (2,4-dihydroxybenzophenone) was associated with endometriosis, an estrogen dependent gynecologic disease (17). Also, urinary concentration of specific BP-type UV filters in men were associated with diminished couple fecundity manifesting in a longer time required to achieve pregnancy (18). In light of these emerging data, we explored the relation between five BP-type UV filters and semen quality among men recruited from the general population who were not seeking clinical care.…”

Section: Introductionmentioning

confidence: 99%

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Urinary concentrations of benzophenone-type ultraviolet light filters and semen quality

Louis

Chen

Kim

et al. 2015

Fertility and Sterility

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Objective To assess benzophenone-type ultra violet (UV) filter concentrations, chemicals used in sunscreen and personal care products, and semen endpoints. Design Cohort. Setting 16 counties in Michigan and Texas Participants 413 men provided semen and urine samples, 2005–2009. Five UV filters were quantified (ng/mL) in urine using liquid chromatography-triple-quadrupole mass spectrometry: BP-1 (2,4-dihydroxybenzophenone), BP-2 (2,2′,4,4′-tetrahydroxybenzophenone), BP-3 (2-hydroxy-4-methoxybenzophenone), BP-8 (2,2′-dihydroxy-4-methoxybenzophenone), and 4-OH-BP (4-hydroxybenzophenone). Using linear regression, beta coefficients (β) and 95% confidence intervals (CIs) for each chemical dichotomized at the 75th percentile and Box-Cox transformed semen endpoint were estimated, after adjusting for age, BMI, cotinine, season, and site. Interventions None. Main Outcome Measures 35 semen endpoints. Results BP-2 was associated with diminished sperm concentration (β=−0.74; 95% CI −1.41, −0.08), straight (β=−4.57; 95% CI −8.95, −0.18) and linear movement (β=−3.15; 95% CI −6.01, −0.30), more immature (β=0.38; 95% CI 0.15, 0.62) sperm, and a decreased percentage of other tail abnormalities (β=−0.16; 95% CI −0.31, −0.01). BP-8 was associated with decreased hypo-osmotic swelling (β=−2.57; 95% CI −4.86, −0.29) and higher acrosome area (β=1.14; 95% CI 0.01, 2.26). No associations were observed for BP-1, BP-3 or 4OH-BP. Conclusion The findings suggest that specific UV filters may be associated with some aspects of semen endpoints, but await future corroboration.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Urinary concentrations of benzophenone-type ultraviolet light filters and semen quality

Louis

Chen

Kim

et al. 2015

Fertility and Sterility

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“…Male blood lead was associated with a 15% reduction in couple fecundity (Buck Louis et al 2012), and similarly so for p,p’- DDE along with a range of 17%-29% reduction for 7 PCB congeners (Buck Louis et al 2013). Three phthalates (mBP, mBzP, mMP) were associated with an 18%-23% reduction in fecundity based upon male partners (Buck Louis et al 2014a), along with a 26% to 31% reduction for two BP-filters (BP-2 and 4OH-BP) (Buck Louis et al 2014b). Of the 19 significant chemical findings in either partner found associated with TTP, only 3 reflected higher fecundity as measured by a shorter TTP: male PCB congener #101 and female mCPP and mOP.…”

Section: Resultsmentioning

confidence: 99%

“…No significant trend in BP-3 concentrations and semen quality parameters was observed, nor was there an association with BPA (Chen et al 2013). Neither BP-3 nor BPA was associated with couple fecundity in the LIFE Study (Buck Louis et al 2014a, 2014b). We are unaware of any previous research on BP-2 or 4OH-BP found to be associated with TTP in our study.…”

Section: Discussionmentioning

confidence: 97%

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Paternal exposures to environmental chemicals and time‐to‐pregnancy: overview of results from theLIFEstudy

et al. 2016

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Published findings from the Longitudinal Investigation of Fertility and the Environment (LIFE) Study regarding the relation between environmental chemicals and couple fecundity, as measured by time-to-pregnancy (TTP), are reviewed with a particular focus on role of the male partner. The LIFE Study recruited 501 couples from 16 counties in two U.S. states upon discontinuing contraception for purposes of becoming pregnant. Upon enrollment, couples provided a blood and urine sample for the quantification of persistent and non-persistent environmental chemicals, respectively, and then completed daily journals until pregnant or up to one year of trying. Female partners used fertility monitors to aid the timing of intercourse relative to ovulation, and digital home pregnancy test kits on the day of expected menses. Chemical classes included: metals, persistent organic pollutants, environmental phenols, and phthalates that were quantified using inductively coupled plasma mass spectrometry or isotope dilution high resolution or tandem mass spectrometry. Time-to-pregnancy (TTP) was defined as the number of prospectively observed menstrual cycles required for pregnancy. Fecundability odds ratios (FORs) and 95% confidence intervals (CIs) were estimated for each chemical and partner after adjusting for potential confounders and accounting for right censoring and time off contraception. FORs <1 are suggestive of diminished fecundity or a longer TTP. Significant reductions (ranging from 17% to 31%) in couple fecundity were observed for male partners’ concentration of lead (0.83; 0.70, 0.98), 2,2′,4,4′-tetrahydroxybenzophenone (0.69; 0.49, 0.97), monobenzyl (0.80; 0.67, 0.97) and monomethyl (0.81; 0.70, 0.94) phthalates after adjusting for the female partners’ concentrations. Seven PCB congeners quantified in men's serum were associated with a 17% to 29% reduction in couple fecundity. Our findings underscore the importance of a couple based exposure design, inclusive of the male partner, when assessing couple dependent outcomes such as TTP to avoid misinterpretation of results based only upon the female partner.

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Maternal Benzophenone Exposure Impairs Hippocampus Development and Cognitive Function in Mouse Offspring

et al. 2021

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Benzophenones are widely supplemented in personal care products, but little is known about its neurodevelopmental toxicity. The previous epidemiological study discovered a negative correlation between maternal exposure to a benzophenone metabolite 4-hydroxybenzophenone (4HBP) and child's neurodevelopment, yet the causal relationship and detailed mechanism remain to be defined. Here, it is reported that prenatal, but not postnatal, exposure to environmentally relevant level of 4HBP impairs hippocampus development and causes cognitive dysfunction in offspring mice. Transcriptomic analyses reveal that 4HBP induces the endoplasmic reticulum stress-induced apoptotic signaling and inflammatory response in hippocampal neural stem cells. Mechanistically, 4HBP exposure activates protein kinase R-like ER kinase (PERK) signaling, which induces CHOP, inhibits I𝜿B translation, and transactivates p65, thereby promoting inflammation and apoptosis on multiple levels. Importantly, genetic or pharmacological inhibition of PERK pathway significantly attenuates 4HBP-induced NF𝜿B signaling and neurodevelopmental abnormalities in mice and in a human brain organoid model. The study uncovers the neurodevelopmental toxicity of BP and cautions its exposure during pregnancy.

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Urinary Concentrations of Benzophenone-Type Ultraviolet Radiation Filters and Couples' Fecundity

Cited by 85 publications

References 39 publications

Urinary concentrations of benzophenone-type ultraviolet light filters and semen quality

Urinary concentrations of benzophenone-type ultraviolet light filters and semen quality

Paternal exposures to environmental chemicals and time‐to‐pregnancy: overview of results from theLIFEstudy

Maternal Benzophenone Exposure Impairs Hippocampus Development and Cognitive Function in Mouse Offspring

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