Urinary Chromium Excretion in Response to an Insulin Challenge Is Not a Biomarker for Chromium Status

Love, Seth; Bona, Kristin R. Di; Sinha, Sarmistha; McAdory, DeAna; Skinner, Brittany R.; Rasco, Jane F.; Vincent, John B.

doi:10.1007/s12011-012-9594-3

Cited by 15 publications

(8 citation statements)

References 25 publications

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“…On the contrary, Anderson et al [ 45 ] observed a reduce Fe content in the tissues of rats supplemented with chromium(III) chloride. Similarly, the results obtained by Ani and Moshtaghie [ 46 ] reported that decreased transferrin saturation and tissue stores of Fe as well as reduce haemoglobin and haematocrit indices in animals fed a diet with a high content of Cr(III). This was an antagonistic competition between trivalent chromium and trivalent iron for binding to apotransferrin [ 8 , 9 ].…”

Section: Discussionsupporting

confidence: 64%

“…did not cause significant changes in content of Fe in the liver and kidney. Likewise, Love et al [ 46 ] found that the supplementary Cr(III) (16–2000 μg kg −1 diet) given for 23 weeks had no effect on the blood iron concentration in ZKL rats. No adverse effects of Cr3 on the Fe status when given to normal and with type 2 diabetes rats for 24 weeks at doses of 250–1000 μg of Cr kg −1 b.w.…”

Section: Discussionmentioning

confidence: 99%

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The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats

Staniek

Wójciak

2017

Biol Trace Elem Res

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Inadequate iron supply has significant consequences to health. There are some relations between the metabolism of different trace elements, such as iron, zinc, copper and chromium. However, the direction of these interactions can be antagonistic or synergistic, and it depends on many factors. The aim of the study was to evaluate the combined effects of supplementary of chromium(III) propionate complex (Cr3) with iron excess on the Cr and Fe status in healthy female rats. The 36 healthy female Wistar rats were divided into six experimental groups (six animals in each) with different Fe levels—adequate (45 mg kg−1—100% RDA) and high (excessive—180 mg kg−1—400% RDA). At the same time, they were supplemented with Cr(III) at doses of 1, 50 and 500 mg kg−1 of diet: C1—control (Fe 45 mg kg−1, Cr 1 mg kg−1); C50 (Fe 45 mg kg−1, Cr 50 mg kg−1); C500 (Fe 45 mg kg−1, Cr 500 mg kg−1); H1 (Fe 180 mg kg−1, Cr 1 mg kg−1); H50 (Fe 180 mg kg−1, Cr 50 mg kg−1); H500 (Fe 180 mg kg−1, Cr 500 mg kg−1). The serum iron level and total iron binding capacity (TIBC) were measured with colorimetric methods. The serum ferritin level was measured by means of electrochemiluminescence immunoassay. The serum transferrin level was measured with the ELISA method. Haematological measurements were made with an automated blood analyser. The Cr and Fe tissular levels were measured with the AAS method. The exposure to a high level of Fe(III) alone or in combination with Cr caused Fe accumulation in tissues, especially in the liver and kidneys, but there were no significant changes in the TIBC, transferrin, ferritin concentration in the serum and most haematological parameters. Moreover, the serum, hepatic and renal Cr concentrations decreased. The doses of supplementary Cr(III) given separately or in combination with high level of Fe(III) disturbed the Cr content in the liver and kidneys of healthy female rats. However, they did not change most of the parameters of Fe metabolism, except the Fe kidney concentration. Supplementary Cr3 decreased the renal Fe level in groups with adequate Fe content in the diet. However, the renal Fe levels increased along with a higher Cr level in the diet in groups with high Fe content. The findings proved a relationship between Fe(III) and Cr(III) metabolism in healthy female rats. However, the direction of change varied and depended on relative amounts of these elements in the diet.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats

Staniek

Wójciak

2017

Biol Trace Elem Res

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“…However, they observed higher liver Fe level and lower kidney Fe concentrations than their controls in Zucker obese (ZKO) rats [ 17 ]. Also, Love et al [ 56 ] observed that the dietary Cr (16–2000 μg· kg −1 diet) given for 23 weeks had no effect on the blood iron level in Zucker lean (ZKL) rats. Similarly, Clodfelder et al [ 4 ] did not observe adverse effects of Cr3 on the Fe status when given to healthy rats or to the animals with type 2 diabetes for 24 weeks as an aqueous solution at doses of 250–1000 μg of Cr· kg −1 b.m.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Supplementary Cr3 (Chromium(III) Propionate Complex) on the Mineral Status in Healthy Female Rats

Staniek

Krejpcio

2017

Biol Trace Elem Res

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More and more people use food supplements for various reasons, e.g. to prevent mineral deficiency and diseases (e.g. osteoporosis, diabetes, anaemia). Supplements containing Cr(III) are purchased primarily for weight loss and antidiabetic effects. The aim of this study was to evaluate the effects of supplementary Cr3 {chromium(III) propionate complex, [Cr3O(O2CCH2CH3)6(H2O)3]NO3)} on the mineral status in female Wistar rats. The study was carried out on 30 female Wistar rats, divided into five groups (six animals in each): a control group and test groups fed Cr3 supplemented diets with 100, 200, 500 and 1000 mg Cr · kg−1 diet (equivalent to 10, 20, 50 and 100 mg Cr ·kg−1 body mass (b.m.) per day) given as Cr3 for 4 weeks. Supplementary Cr3 increased the Cr content in tissues in a dose-dependent manner. High dietary doses of Cr3, 20 and 100 mg Cr · kg−1 b.m., increased the Cu content in the liver and spleen as well as the Zn content in the kidneys but decreased the liver Ca content. Doses of 50–100 mg Cr ·kg−1 b.m. decreased the serum Fe concentration and the Fe content in the liver and kidneys. Supplementation with Cr3 at doses of 10 and 100 mg Cr ·kg−1 b.m. did not affect the Mg content in the rats’ tissues. In conclusion, high dietary doses of Cr3 (10 and 100 mg Cr· kg−1 b.m.) given for 4 weeks affected the mineral status of Fe, Zn, Cu and Ca in the tissues of healthy female Wistar rats.

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“…Both the plasma concentrations and the hair levels of chromium were associated with intake in different Greek regions. Urinary chromium may not be a valid biomarker for chromium intake [ 162 ]. There is a need for better biomarkers of chromium intake [ 163 ].…”

Section: Amino Acids Proteins Minerals and Trace Elementsmentioning

confidence: 99%

Biomarkers for nutrient intake with focus on alternative sampling techniques

et al. 2016

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Biomarkers of nutrient intake or nutrient status are important objective measures of foods/nutrients as one of the most important environmental factors people are exposed to. It is very difficult to obtain accurate data on individual food intake, and there is a large variation of nutrient composition of foods consumed in a population. Thus, it is difficult to obtain precise measures of exposure to different nutrients and thereby be able to understand the relationship between diet, health, and disease. This is the background for investing considerable resources in studying biomarkers of nutrients believed to be important in our foods. Modern technology with high sensitivity and specificity concerning many nutrient biomarkers has allowed an interesting development with analyses of very small amounts of blood or tissue material. In combination with non-professional collection of blood by finger-pricking and collection on filters or sticks, this may make collection of samples and analyses of biomarkers much more available for scientists as well as health professionals and even lay people in particular in relation to the marked trend of self-monitoring of body functions linked to mobile phone technology. Assuming standard operating procedures are used for collection, drying, transport, extraction, and analysis of samples, it turns out that many analytes of nutritional interest can be measured like metabolites, drugs, lipids, vitamins, minerals, and many types of peptides and proteins. The advantage of this alternative sampling technology is that non-professionals can collect, dry, and mail the samples; the samples can often be stored under room temperature in a dry atmosphere, requiring small amounts of blood. Another promising area is the potential relation between the microbiome and biomarkers that may be measured in feces as well as in blood.

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Urinary Chromium Excretion in Response to an Insulin Challenge Is Not a Biomarker for Chromium Status

Cited by 15 publications

References 25 publications

The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats

The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats

The Effects of Supplementary Cr3 (Chromium(III) Propionate Complex) on the Mineral Status in Healthy Female Rats

Biomarkers for nutrient intake with focus on alternative sampling techniques

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