Urinary CD4+ T Cells Predict Renal Relapse in ANCA-Associated Vasculitis
Luka Prskalo,
Christopher M. Skopnik,
Nina Goerlich
et al.
Abstract:Background:
In ANCA-associated vasculitis (AAV) there is a lack of biomarkers for predicting renal relapse. Urinary T cells have been shown to differentiate active glomerulonephritis from remission in AAV, but their predictive value for renal flares remains unknown.
Methods:
The PRE-FLARED study is a prospective multicenter biomarker study including 102 individuals with AAV in remission, aimed to predict renal relapse by quantifying urinary CD4+ T cell … Show more
“…In this issue of JASN, Prskalo et al provide evidence that a certain measure of urinary CD4 1 T cells is associated with disease activity. 5 The authors propose that the urinary lymphocyte count outperforms other urinary diagnostics, such as microscopic hematuria. In the prospective multicenter PRE-FLARED study, urinary CD4 1 T cells were associated with an early return of intrarenal inflammation requiring an escalation of treatment soon after completing induction immunosuppression.…”
“…In this issue of JASN, Prskalo et al provide evidence that a certain measure of urinary CD4 1 T cells is associated with disease activity. 5 The authors propose that the urinary lymphocyte count outperforms other urinary diagnostics, such as microscopic hematuria. In the prospective multicenter PRE-FLARED study, urinary CD4 1 T cells were associated with an early return of intrarenal inflammation requiring an escalation of treatment soon after completing induction immunosuppression.…”
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