Urinary catecholamines and metabolites in children

“…Their values were considerably lower than ours and they used Gaussian statistics ignoring the obvous skew in their data. They favoured expressing their results in relation to body surface area, like De Schaepdryver et al, 22 but the latter found no consistent change in the excretion of catecholamines or their metabolites with increasing size. Using HPLC methods, Rosano-' also found that the excretion of adrenaline, noradrenaline and dopamine decreased with age and quoted reference values considerably lower than ours but higher than those of Premel-Cabic et al 19 Pediatric reference ranges for catecholamines based on 24 h collections were determined by Moyer et al 24 but were not related to urinary creatinine.…”

Section: Precisionmentioning

confidence: 90%

Reference Values for Urinary HMMA, HVA, Noradrenaline, Adrenaline, and Dopamine Excretion in Children Using Random Urine Samples and HPLC with Electrochemical Detection

Fitzgibbon¹,

Fitzgerald²,

Tormey³

et al. 1992

Ann Clin Biochem

View full text Add to dashboard Cite

SUMMARY. Random urine samples were collected from 305 children aged from birth to 14 years and the values of hydroxymethoxymandelic acid, homovanillic acid, noradrenaline, adrenaline, and dopamine were measured by high-performance liquid chromatography with electrochemical detection. The results were reported relative to the urinary creatinine concentration and the values declined progressively with increasing age for each analyte with the exception of adrenaline. The results for each age group were not normally distributed and all values except outliers were retained in determining the upper reference limits. Additional key phrases: catecholamines; vanillylmandelic acidIn children, the urinary excretion of biogenic amines and their metabolites increases with agel but when these values are related to the urinary creatinine excretion the relative values decrease.P Changing reference values are particularly important in the diagnosis of tumours such as neuroblastoma, 750/0 of which occur before the age of 4 years. The validity and convenience of random urine samples for these analytes has been accepted.v? Relating excretion to urinary creatinine which is produced at a constant rate minimizes the differences in children of similar ages due to size or sex," although this is controversial." Taking daytime samples minimizes the influence of diurnal variation. 1In neuroectodermal tumours, the pattern of urinary excretion of amines and their metabolites varies widely and dopamine as well as the adrenaline and noradrenaline pathways should be assessed to maximize the sensitivity of the biochemical test. 8.9 Recently reported data from the European Neuroblastoma Study Group concluded that the screening of infants using urinary hydroxymethoxymandelic acid (HMMA) and homovanillic acid (HV A) The widely differing published reference values for the excretion of catecholamines and their metabolites reflect the diversity of analytical methods and data manipulations used. Reports from the United Kingdom External Quality Assessment Scheme (UKEQAS) for urinary catecholamines confirm the continuing large variation in laboratory analytical performance. With increasing interest in screening programmes aimed at improving the detection rate of neuroblastoma, and hopefully the prognosis, the importance of establishing detailed reference ranges cannot be overstated. Thus we report our age and creatinine related upper reference limits for urinary adrenaline, noradrenaline, dopamine, HMMA, and HVA using high-performance liquid chromatography (HPLC) with electrochemical (EC) detection. MATERIALS AND METHODSRandom urine samples were collected from 305 well children. These included 198 attending orthopaedic outpatient clinics, 44 from a general practice age register, 33 from neonatal and 6 week post partum routine hospital baby checks and 30 from a daycare nursery. All specimens were collected during the normal working day.

show abstract

“…Studies that report urinary dopamine levels are few, and relate mainly to older children. Such studies include the reports of De Schaepdruver et al [3] and Voorhess [13]. In the former, the youngest child was 1 month old, and in the latter only four patients were younger than 5 weeks of age.…”

Section: Introductionmentioning

confidence: 99%

Urinary catecholamine levels in the newborn infant

1985

View full text Add to dashboard Cite

The urinary concentrations of dopamine, noradrenaline and adrenaline were measured by a radioenzymatic method in 212 full-term and premature newborns. The ranges, means and standard deviations from birth to 4 days + are presented. The excretion of dopamine was ten times that of noradrenaline or adrenaline. The absolute concentrations of each catecholamine were reduced as birth weight decreased. The values were increased in babies with fetal distress. Any changes found in hypoglycaemic or jaundiced infants were attributable to prematurity. Very high levels were found in a few infants given tolazoline. We speculate that the role of dopamine production and excretion in the newborn has been underestimated. Dopamine may have an important role to play in the homeostatic mechanisms of the newborn.

show abstract

Urinary catecholamines and metabolites in children

Cited by 30 publications

References 5 publications

Biopterin synthesis defect. Treatment with L-dopa and 5-hydroxytryptophan compared with therapy with a tetrahydropterin.

Biopterin synthesis defect. Treatment with L-dopa and 5-hydroxytryptophan compared with therapy with a tetrahydropterin.

Reference Values for Urinary HMMA, HVA, Noradrenaline, Adrenaline, and Dopamine Excretion in Children Using Random Urine Samples and HPLC with Electrochemical Detection

Urinary catecholamine levels in the newborn infant

Contact Info

Product

Resources

About