Urinary cadmium in relation to bone damage: Cadmium exposure threshold dose and health-based guidance value estimation

Qing, Ying; Yang, Jiaqi; Chen, Yanfeng; Shi, Chengjie; Zhang, Qianrong; Ning, Zhongping; Yu, Ying; Li, Yanfei

doi:10.1016/j.ecoenv.2021.112824

Cited by 23 publications

(11 citation statements)

References 50 publications

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“…Exposure to Cd compounds may create serious health problems, including kidney damage (Hernandez-Cruz et al 2022), effect on reproductive biology (Zhao et al 2017), osteotoxicity (Qing et al 2021), carcinogenesis (Liu et al 2013) and cardiovascular abnormality (Tellez-Plaza et al 2013). In addition, Cd acute exposures may lead to inflammation followed by cough, dryness, nose and throat irritation, headache, dizziness, chest pain, pneumonitis, and pulmonary edema (Luevano et al 2014;Roy et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Pollution Assessment of Selected Heavy Metals in Irrigation Water

Shah

Munshi

Islam

et al. 2023

Preprint

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Irrigation water is an important factor in proper crop production. Thus irrigation water plays a vital role in food safety and security. This study, therefore, focuses on the estimation of the concentration of four heavy metals in irrigation water along with their pollution assessments. The concentration of heavy metals found in this study followed the order of Mn (0.0913-0.3701 mg/L) > Pb (0.0211-0.2104 mg/L) > Cd (0.0004-0.0222 mg/L) > Cr (0.00105-0.00937 mg/L). In a few cases, the concentrations of heavy metals exceed the permissible limit for irrigation water recommended by the Food and Agricultural Organization. Pollution assessments were carried out using the enrichment factor, geoaccumulation index, contamination factor, and modified degree of contamination. This study revealed that the enrichment factor for lead and chromium showed no enrichment, whereas cadmium showed minor to moderate enrichment, and manganese was used as a reference element. The geoaccumulation index and contamination factor demonstrate that lead and chromium were uncontaminated, but manganese and cadmium denote moderate contamination. The modified degree of contamination indicated nil to the lower degree of contamination for all samples. Proper steps by the government and different organizations should be taken to identify the reasons for their sources, and appropriate techniques should be implemented to reduce their concentrations.

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Section: Introductionmentioning

confidence: 99%

Pollution Assessment of Selected Heavy Metals in Irrigation Water

Shah

Munshi

Islam

et al. 2023

Preprint

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“…Exposure to Cd disrupts osteoblast metabolism, collagen production, and also increases the urinary excretion of calcium and phosphorus. In children, it can disturb growth and damage bones [ 4 ]. Cd is present in grains, rice, fish and seafood, and vegetables [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Health Safety Assessment of Ready-to-Eat Products Consumed by Children Aged 0.5–3 Years on the Polish Market

et al. 2022

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Toxic elements have a negative impact on health, especially among infants and young children. Even low levels of exposure can impair the normal growth and development of children. In young children, all organs and metabolic processes are insufficiently developed, making them particularly vulnerable to the effects of toxic elements. The aim of this study is to estimate the concentration of toxic elements in products consumed by infants and young children. The health risk of young children due to consumption of ready-made products potentially contaminated with As (arsenic), Cd (cadmium), Hg (mercury), and Pb (lead) was also assessed. A total of 397 samples (dinners, porridges, mousses, snacks “for the handle”, baby drinks, dairy) were analyzed for the content of toxic elements. Inductively coupled plasma mass spectrometry (ICP-MS) was used to assess As, Cd, and Pb concentration. The determination of Hg was performed by atomic absorption spectrometry (AAS). In order to estimate children’s exposure to toxic elements, the content of indicators was also assessed: estimated daily intake (EDI), estimated weekly intake (EWI), provisional tolerable weekly intake (PTWI), provisional tolerable monthly intake (PTMI), the benchmark dose lower confidence limit (BMDL), target hazard quotient (THQ), hazard index (HI), and cancer risk (CR). The average content of As, Cd, Hg, and Pb for all ready-made products for children is: 1.411 ± 0.248 µg/kg, 2.077 ± 0.154 µg/kg, 3.161 ± 0.159 µg/kg, and 9.265 ± 0.443 µg/kg, respectively. The highest content As was found in wafer/crisps (84.71 µg/kg); in the case of Cd, dinners with fish (20.15 µg/kg); for Hg, dinners with poultry (37.25 µg/kg); and for Pb, fruit mousse (138.99 µg/kg). The results showed that 4.53% of the samples attempted to exceed Pb, and 1.5% exceeded levels of Hg. The highest value of THQ was made in the case of drinks, for Cd and Pb in mousses for children, and Hg for dairy products. The THQ, BMDL, and PTWI ratios were not exceeded. The analyzed ready-to-eat products for children aged 0.5–3 years may contain toxic elements, but most of them appear to be harmless to health.

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“…Likewise, cadmium (Cd) is classified within the first group of carcinogens by the International Agency for Research on Cancer (IARC) as a highly toxic metal [16,17]. It also causes decreased bone density and kidney damage [18]. Finally, mercury is a toxic metallic element that affects human health, wildlife, aquatic ecosystems (severe and persistent toxicity has been documented from the contaminated fish consumption from fresh and marine waters [4]) and, in general, soils, water and air [19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Recognition of Heavy Metals by Using Resorcin[4]arenes Soluble in Water

Sanabria

Esteso

Vargas

2022

Toxics

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The complexing properties of two water-soluble resorcin[4]arenes (tetrasodium 5,11,17,23-tetrakissulfonatemethylen 2,8,14,20-tetra(butyl)resorcin[4]arene, Na4BRA, and tetrasodium 5,11,17,23-tetrakissulfonatemethylen-2,8,14,20-tetra(2-(methylthio)ethyl)resorcin[4]arene, Na4SRA) with polluting heavy metals such as Cu2+, Pb2+, Cd2+ and Hg2+ were studied by conductivity, and the findings were confirmed by using other techniques to try to apply this knowledge to removing them. The results indicate that Na4BRA is able to complex Cu2+ in a 1:1 ratio and Pb2+ in a 1:2 ratio, while Na4SRA complexes Hg2+ in a 1:1 ratio. On the contrary, no indications have been observed that either of the resorcin[4]arenes studied complexes the Cd2+ ions. The results suggest that the bonds established between the sulfur atoms located at the lower edge of the SRA4− and the solvent hydrogens could prevent the entry of the guest into the host cavity. However, in the case of Hg2+ ions, the entry is favoured by the interactions between the sulfur donor atoms present on the lower edge of Na4SRA and the Hg2+ ions. Therefore, it can be said that Na4BRA is selective for Cu2+ and Pb2+ ions and Na4SRA is selective for Hg2+ ions.

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Urinary cadmium in relation to bone damage: Cadmium exposure threshold dose and health-based guidance value estimation

Cited by 23 publications

References 50 publications

Pollution Assessment of Selected Heavy Metals in Irrigation Water

Pollution Assessment of Selected Heavy Metals in Irrigation Water

Health Safety Assessment of Ready-to-Eat Products Consumed by Children Aged 0.5–3 Years on the Polish Market

Recognition of Heavy Metals by Using Resorcin[4]arenes Soluble in Water

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