Urinary bladder xanthomatous cystitis

Shah, Shrenik; Ajitsaria, Vineet; Singh, Vineet

doi:10.4103/0970-1591.195761

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…However, CD68 expression is present in both macrophages and tissue cells, with only signet ring cell carcinoma displaying CD68 negativity. Both bladder xanthoma and bladder softening disease exhibit CD68 positivity, making this method less specific [8,22].…”

Section: Discussionmentioning

confidence: 99%

Bladder xanthoma: clinical analysis of 22 cases from multiple centers

2024

Am J Clin Exp Urol

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This study aims to outline the clinical and pathological characteristics of bladder xanthoma, alongside its diagnostic and treatment approaches. Methods: We reviewed bladder xanthoma literature spanning the last 60 years from databases such as PubMed, Web of Science, Embase, and Medline. Additionally, we analyzed clinical data from a singular case of bladder xanthoma treated at our hospital. Patient particulars, including age, gender, symptoms, tumor size, associated neoplasms, imaging results, and pathological findings, were documented. Tumors underwent surgical removal, followed by pathological examination of the excised tissues. Subsequent to surgery, patients underwent cystoscopy follow-up after 3 months. Results: Among the 22 identified cases of bladder xanthoma, 15 were solitary (comprising both single and multiple lesions), while 7 were associated with urinary tract epithelial tumors. There were 6 male patients and 1 female patient concurrently diagnosed with urinary tract epithelial carcinoma. Males exhibited an average onset age of 56.0 years, with an average tumor diameter of 21.57 mm. Females presented an average onset age of 63.00 years, with an average tumor diameter of 20.86 mm. The onset age for females was notably lower than that for males, and their tumor diameter was significantly smaller than that of males (P<0.05). Among the 9 patients with lipid metabolism disorders, 7 were males and 2 were females, indicating a marked male predominance. No instances of recurrence or malignant transformation were observed during followup. In this study, we treated a 65-year-old female patient who, during cystoscopy, exhibited a round, hanging lesion measuring about 2.5 × 1 × 1 cm on the left side of the ureteral opening in the bladder trigone. Post-surgery, pathological examination disclosed bladder xanthoma with multiple groups of foam cells. Immunohistochemistry findings were as follows: CD68 (+), CD163 (+), Vimentin (+), CK (-), Desmin (-). A follow-up cystoscopy after 3 months did not reveal any tumor recurrence. Conclusion: Bladder xanthoma is an uncommon benign condition predominantly affecting older males. It frequently manifests on the side walls and trigone region of the bladder and may be linked to lipid metabolism disorders. Approximately 50% of patients exhibit concurrent urinary tract epithelial tumors, with diagnosis primarily reliant on microscopic tissue examination. Prolonged post-surgical follow-up is imperative.

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Section: Discussionmentioning

confidence: 99%

Bladder xanthoma: clinical analysis of 22 cases from multiple centers

2024

Am J Clin Exp Urol

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“…13 Xanthoma is a benign condition with no known cases of malignant transformation. However, 15 2,[11][12][13] of the 31 cases reviewed during our literature search had coexisting neoplasms. Most of these neoplasms were incidental findings and were of low grade with minimal clinical significance.…”

Section: Discussionmentioning

confidence: 99%

Bladder Xanthoma

Ameen

Ahn

Carton

et al. 2022

Journal of Endoluminal Endourology

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A 35-year-old male presented with multiple interrupted episodes of frank hematuria and persistent microscopic hematuria. CT urogram demonstrated a nonspecific lesion in the bladder. Cystoscopy showed a lesion in the bladder wall that was biopsied, and histopathology confirmed a xanthoma, a rare diagnosis in the bladder. This case report performs a review of current literature and examines necessary investigations,differential diagnoses, and management required for bladder xanthoma.

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“…However, CD68 expression is present in both macrophages and tissue cells, with only signet ring cell carcinoma displaying CD68 negativity. Bladder xanthoma and bladder softening disease both exhibit CD68 positivity, rendering this method less speci c[8,22].For bladder xanthoma treatment, various viewpoints exist. Some experts argue that managing lipid metabolism irregularities might su ce in cases of solitary bladder xanthoma accompanied by hyperlipidemia.…”

mentioning

confidence: 99%

Bladder Xanthoma: Clinical Analysis of 22 Cases from Multiple Centers

Li,

Zhao,

Zhang

et al. 2023

Preprint

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Objective This study aims to describe the clinical and pathological features of bladder xanthoma, along with its diagnostic and treatment methods. Methods We gathered literature about bladder xanthoma published over the past 60 years from databases like PubMed, Web of Science, Embase, and Medline. We also collected clinical data from a single case of bladder xanthoma treated at our hospital. Patient details such as age, gender, symptoms, tumor size, related neoplasms, imaging results, and pathological findings were noted. Tumors were removed through surgery, followed by examining the removed tissues pathologically. After surgery, patients underwent cystoscopy follow-up after 3 months. Results Out of the 22 identified cases of bladder xanthoma, 15 were isolated (including both single and multiple lesions), while 7 were connected with urinary tract epithelial tumors. There were 6 male patients and 1 female patient with concurrent urinary tract epithelial carcinoma. Males had an average onset age of 56.0 years, with an average tumor diameter of 21.57 mm. Females had an average onset age of 63.00 years, with an average tumor diameter of 20.86 mm. The onset age for females was notably lower than that for males, and their tumor diameter was significantly smaller than that of males (P < 0.05). Among the 9 patients with lipid metabolism disorders, 7 were males and 2 were females, showing a significant male predominance. No instances of recurrence or malignant transformation were noted during follow-up. In this study, we treated a 65-year-old female patient who, during cystoscopy, showed a round, hanging lesion measuring about 2.5 x 1 x 1 cm on the left side of the ureteral opening in the bladder trigone. After surgery, pathological examination revealed bladder xanthoma with multiple groups of foam cells. Immunohistochemistry findings were as follows: CD68 (+), CD163 (+), Vimentin (+), CK (-), Desmin (-). A follow-up cystoscopy after 3 months did not uncover any tumor recurrence. Conclusion Bladder xanthoma is a rare non-cancerous condition that mainly affects older males. It often appears on the side walls and trigone region of the bladder and could be associated with lipid metabolism disorders. Around 50% of patients have simultaneous urinary tract epithelial tumors, and diagnosis mainly depends on examining tissues under a microscope. Prolonged follow-up after surgery is not necessary.

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Urinary bladder xanthomatous cystitis

Cited by 3 publications

References 5 publications

Bladder xanthoma: clinical analysis of 22 cases from multiple centers

Bladder xanthoma: clinical analysis of 22 cases from multiple centers

Bladder Xanthoma

Bladder Xanthoma: Clinical Analysis of 22 Cases from Multiple Centers

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