Urinary bladder volumetry by means of a single retrosymphysically implantable ultrasound unit

Seif, C.; Herberger, Björgulf; Cherwon, Elly; Portillo, F. J. Martínez; Molitor, Mark; Böhler, G.; Zendler, S.; Jünemann, K. P.; Braun, P.

doi:10.1002/nau.10144

Cited by 12 publications

(9 citation statements)

References 32 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In vivo devices have the advantage of being able to monitor real‐time bladder volume. One study explained the usefulness of monitoring changes in bladder volume through the comparison of in vivo ultrasonography with external bladder ultrasonography [2]. The ultrasonography equipment used by those investigators was significant when the solution within the bladder was more than 50 mL during a urodynamic study; therefore, the usefulness of such equipment may be low in an experiment with small animal models.…”

Section: Discussionmentioning

confidence: 99%

“…The distance ( d ) between the electrodes was converted from capacitance measured by the Locus Control Region meter (Agilent, CA, USA), which was externally connected to both electrodes during the infusion of saline into the urinary bladder. Assuming the filled bladder shape was a sphere, the bladder volume was estimated by applying the sphere volume formula (1/6π d 3 ) to simplify the process [2]. Concurrently, bladder pressure was recorded in the polygraph (Grass 7D; Grass Inst.…”

Section: Experimental Methodsmentioning

confidence: 99%

“…Until now, several in vivo studies have been conducted on the measurement of bladder volume in real time, and the results are very encouraging. These pioneering research studies led to the development of new kinds of equipment for monitoring bladder volume in neurogenic bladder patients [2,3]. However, because of the sizes of the bladder volume monitoring devices and their sensitivities, such devices have limitations for application to small animal models.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Real‐time bladder volume monitoring by the application of a new implantable bladder volume sensor for a small animal model

Lee

Kim

Sohn

et al. 2011

The Kaohsiung J of Med Scie

View full text Add to dashboard Cite

Although real-time monitoring of bladder volume together with intravesical pressure can provide more information for understanding the functional changes of the urinary bladder, it still entails difficulties in the accurate prediction of real-time bladder volume in urodynamic studies with small animal models. We studied a new implantable bladder volume monitoring device with eight rats. During cystometry, microelectrodes prepared by the microelectromechanical systems process were placed symmetrically on both lateral walls of the bladder, and the expanded bladder volume was calculated. Immunohistological study was done after 1 week and after 4 weeks to evaluate the biocompatibility of the microelectrode. From the point that infused saline volume into the bladder was higher than 0.6 mL, estimated bladder volume was statistically correlated with the volume of saline injected (p<0.01). Additionally, the microelectromechanical system microelectrodes used in this study showed reliable biocompatibility. Therefore, the device can be used to evaluate changes in bladder volume in studies with small animals, and it may help to provide more information about functional changes in the bladder in laboratory studies. Furthermore, owing to its biocompatibility, the device could be chronically implanted in conscious ambulating animals, thus allowing a novel longitudinal study to be performed for a specific purpose.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Experimental Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Real‐time bladder volume monitoring by the application of a new implantable bladder volume sensor for a small animal model

Lee

Kim

Sohn

et al. 2011

The Kaohsiung J of Med Scie

View full text Add to dashboard Cite

show abstract

“…Although the technique works under well-controlled conditions, it is sensitive to probe movement, posture and interfering factors such as bowel function. 16,25 An implantable miniaturized ultrasound probe was explored in an animal model in 2004, 28 but to the best of our knowledge has not been tested clinically.…”

Section: Introductionmentioning

confidence: 99%

A Phase-Based Electrical Plethysmography Approach to Bladder Volume Measurement

et al. 2015

View full text Add to dashboard Cite

Neuromodulation approaches to treating lower urinary tract dysfunction could be substantially improved by a sensor able to detect when the bladder is full. A number of approaches to this problem have been proposed, but none has been found entirely satisfactory. Electrical plethysmography approaches attempt to relate the electrical impedance of the bladder to its volume, but have previously focused only on the amplitudes of the measured signals. We investigated whether the phase relationships between sinusoidal currents applied through a pair of stimulating electrodes and measured through a pair of recording electrodes could provide information about bladder volume. Acute experiments in a rabbit model were used to investigate how phase-to-volume or amplitude-to-volume regression models could be used to predict bladder volumes in future recordings, with and without changes to the saline conductivity. Volume prediction errors were found to be 6.63 ± 1.12 mL using the phase information and 8.32 ± 3.88 mL using the amplitude information (p = 0.44 when comparing the phase and amplitude results, n = 6), where the volume of the filled bladder was about 25 mL. When a full/empty binary decision rule was applied based on the regression model, the difference between the actual threshold that would result from this rule and the desired threshold was found to be 4.24 ± 0.65 mL using the phase information and 106.92 ± 189.82 mL using the amplitude information (p = 0.03, n = 6). Our results suggest that phase information can form the basis for more effective and robust electrical plethysmography approaches to bladder volume measurement.

show abstract

“…6,15 Implantable ultrasound devices and potentiometers to detect bladder filling and contractions have been studied in pigs. 16,17 Such devices could be helpful in the development of a feedback system in which the neuromodulator automatically activates when the detrusor pressure is increasing. 18 If acute SNM has direct inhibitory effects on bladder function, such a closed-loop feedback system could be of potential value for patients with OAB.…”

mentioning

confidence: 99%

Acute effect of sacral neuromodulation for treatment of detrusor overactivity on urodynamic parameters

Groenendijk

Groen

Scheepe

et al. 2019

Neurourology and Urodynamics

View full text Add to dashboard Cite

Aim: The aim of this study is to evaluate the acute effects of sacral neuromodulation (SNM) on various urodynamic parameters.Methods: Patients with overactive bladder and detrusor overactivity (DO) who were planned for percutaneous nerve evaluation (PNE) were included. Directly after the PNE, a urodynamic study (UDS) was performed. The stimulation was turned off during the first UDS (UDS 1), and during the second filling cycle, stimulation was turned on (UDS 2). The UDS was followed by a test phase of 1week and the bladder diaries were evaluated during an outpatient clinic visit. Primary outcome measures were the differences in UDS parameter values with SNM off and on. Results: Ten female patients were included in the study and completed the study protocol. Eight patients showed ≥50% improvement of symptoms following a test phase. There were no differences between UDS 1 and UDS 2 in the UDS parameters; bladder volume at first sensation, bladder volume at first DO, highest DO pressure, bladder capacity, maximum flow rate, and pressure at maximum flow rate.Discussion: None of the aforementioned urodynamic parameters was influenced by acute SNM in patients who responded to SNM. To the best of our knowledge, this is the first study investigating the acute effects of SNM on bladder function. K E Y W O R D Sacute effect, neuromodulation, overactive bladder, sacral root, urodynamics

show abstract

Urinary bladder volumetry by means of a single retrosymphysically implantable ultrasound unit

Cited by 12 publications

References 32 publications

Real‐time bladder volume monitoring by the application of a new implantable bladder volume sensor for a small animal model

Real‐time bladder volume monitoring by the application of a new implantable bladder volume sensor for a small animal model

A Phase-Based Electrical Plethysmography Approach to Bladder Volume Measurement

Acute effect of sacral neuromodulation for treatment of detrusor overactivity on urodynamic parameters

Contact Info

Product

Resources

About