Urinary bladder chondroma

Abstract

Dear Editor, Soft tissue chondromas are rare tumors that most often occur in the fingers, less commonly in the hands and feet, and rarely in other areas of the body [1]. There has been one previously reported extraskeletal chondroma of the urinary bladder, which occurred in a patient with no prior urologic history [2].A 62-year-old female presented with dysuria, frequency, nocturia, lower abdominal pain, and constipation that had been worsening over the past 4 years. Cystoscopy showed patchy inflammation and erythema, especially pronounced caudad to the right ureteral orifice. Bladder biopsy demonstrated microinvasive highgrade urothelial carcinoma. Cystoscopy with transurethral resection was performed 1.5 months after diagnosis. The prior biopsy site was visualized and resected.In addition, a solid, subepithelial 3-cm mass inconsistent with urothelial carcinoma was seen on the anterior bladder wall. Microscopic examination of the mass revealed a well-circumscribed nodule of mature hyaline cartilage within the lamina propria, surrounded by dense fibrous tissue (Fig. 1a) characterized by sparse, bland-appearing, single cells in the lacunae on a smooth, pale blue, myxoid background with rare calcifications (Fig. 1b). The lesion immunohistochemically expressed S100 (Fig. 1c) and vimentin but was negative for AE1/3, p53, and Ki-67. No urothelial tumor was present. After transurethral resection, the patient completed 6 weeks of intravesical instillation induction Bacillus Calmette-Guerin chemotherapy followed by cystoscopy that failed to demonstrate recurrent tumor.The bladder chondroma we have described is the second case in the literature. The first published bladder chondroma occurred in a 63-year-old female without previous urologic complaints who presented with pain in her left iliac fossa [2]. Cystoscopy identified a submucosal mass on the ventral dome of the bladder that was treated with transurethral resection [2]. The histologic and immunohistochemical features were similar to our findings with bland, mature hyaline cartilage positive for S100 and vimentin and negative using AE1/3, p53, and Ki-67 [2]. Our case is unique because the bladder chondroma was diagnosed in a patient with a recent diagnosis of high-grade urothelial carcinoma. It is

A rare case of bladder chondroma

“…Only two prior cases of chondroma of the urinary bladder wall have been reported. 1,2 The most common mesenchymal tumours of the bladder are leiomyomas, leiomyosarcomas, and pleomorphic undifferentiated sarcomas (formerly malignant fibrous histiocytoma). 3 In recent years there have also been at least 8 reported cases of perivascular epithelioid cell tumour (PEComa) of the bladder.…”

“…The other bladder chondroma, however, was identified in a woman with a concomitant minimally invasive high-grade urothelial carcinoma of the bladder and symptoms of dysuria, frequency, nocturia, lower abdominal pain, and constipation. 1 It is not possible to know what role, if any, the coexisting urothelial carcinoma played in the development of the latter patient's chondroma. A connection between these two lesions seems unlikely.…”

Scrotal extraosseous chondroma: Case report of an exceedingly unusual presentation and review of the literature

“…They are rare, except of those arising in the hands and feet of middle-aged adults [1] . A literature review revealed only eight extraosseous chondromas in the pelvic region, six of them in females [2][3][4][5][6][7][8][9] . Two of these cases were reported in the urinary bladder, in 62 and 63 year-old patients with submucosal solid masses, composed of mature cartilage [2][3] .…”

“…Two of these cases were reported in the urinary bladder, in 62 and 63 year-old patients with submucosal solid masses, composed of mature cartilage [2][3] . Three young patients had fallopian tube lesions; a 32 year-old patient, 30 year-old woman with 3cm×2 cm nodular mass noted on the left tubal serosal area, a 31 year-old patient with 1.6 cm subserosal nodule detected in an elective tubal ligation; contralateral tube was normal [4][5][6] . In Brazil, an 11-year-old girl was referred for a painless solid tumor located on the mons pubis that was diagnosed as chondroma that could be considered a case of chondroma cutis [7] .…”

“…Extraosseous chondromas are exceedingly rare benign tumors that arise in tissue unrelated to bone, except for those arising in the hands and feet of middle-aged adults where they are common [1] . Only eight extraosseous chondromas have been reported in the pelvis, six of them in females, while both male cases have been in the prostate and testis [2][3][4][5][6][7][8][9] . We report an exceedingly rare case of scrotal extraosseous chondroma.…”