Urinary bisphenol A concentrations are associated with reproductive parameters in young men

Adoamnei, Evdochia; Mendiola, Jaime; Vela-Soria, Fernando; Fernández, Mariana F.; Olea, Nicolás; Jørgensen, Niels; Swan, Shanna H.; Torres-Cantero, Alberto M.

doi:10.1016/j.envres.2017.11.002

Cited by 139 publications

(95 citation statements)

References 49 publications

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“…BPA is used as a coating for the inside of food cans, water bottles, baby bottles and some dental fillings (Calafat, Ye, Wong, Reidy, & Needham, ; Takahashi & Oishi, ). It has been reported that BPA is leached from food and beverage containers, and some dental sealants and composites (Howe & Borodinsky, ; Yamamoto & Yasuhara, ) which has been linked with onset of various health disorders such as diabetes, obesity, cardiovascular diseases or carcinogenesis (Adoamnei et al, ; Bansal et al, ; Fénichel & Chevalier, ; Lombó et al, ; Manfo, Jubendradass, Nantia, Moundipa, & Mathur,; Rubin, ). BPA has also been involved in impairing fertility in both men and women as evident by recurrent miscarriages or premature births in women (Rubin, ) or decrease in semen quality and DNA damage of spermatozoa in men (Li et al, , ).…”

Section: Discussionmentioning

confidence: 99%

Alleviating impact of hydroethanolicMurraya koenigiileaves extract on bisphenol A instigated testicular lethality and apoptosis in mice

et al. 2020

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Bisphenol A (BPA) is a well‐known endocrine disruptor that imposees adverse effects on male fertility via interacting with germ cells of testis. Objectives of present study were to investigate the possible protective effects of hydroethanolic Murraya koenigii leaves extract (HEMKLE) against BPA‐induced testicular damage and apoptosis in mice. Male Balb/c mice were divided into four different groups: Group I (control), Group II (HEMKLE), Group III (BPA) and Group IV (HEMKLE + BPA). Group III (BPA) showed significant decrease in sperm parameters, germ cell number along with increased lipid peroxidation (LPO) and reactive oxygen species (ROS). A significant decrease in antioxidant enzymes activity was also observed in Group III (BPA) animals. mRNA expression study revealed significant decrease in the expression of Bcl‐2 and increase in expressions of caspase‐9 and caspase‐3, thus clearly demonstrate BPA‐induced apoptosis. In addition, HEMKLE co‐administration to BPA‐treated mice showed a significant increase in sperm parameters, germ cell number, decreased levels of LPO and ROS, increased antioxidant enzymes activity in Group IV (HEMKLE + BPA). Also, mRNA expression study showed a significant increase in Bcl‐2 and decrease in caspase‐9 and caspase‐3 gene expressions in Group IV (HEMKLE + BPA). Thus, the present study suggests that HEMKLE intervention provides protection against BPA‐induced oxidative stress and apoptosis.

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Section: Discussionmentioning

confidence: 99%

Alleviating impact of hydroethanolicMurraya koenigiileaves extract on bisphenol A instigated testicular lethality and apoptosis in mice

et al. 2020

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“…However, spot urine samples and 24-h urine samples have been reported to produce similar levels of daily BPA intake [57]. Even though BPA has a relatively short half-life, its continuous daily intake contributes to an exposure scenario that is similar to those of bioaccumulative compounds [58,59]. Additionally, if the measurements are not precisely and carefully performed, outcomes are nullified and the effects of exposure could be underestimated.…”

Section: Discussionmentioning

confidence: 99%

Bisphenol a Exposure, DNA Methylation, and Asthma in Children

Yang

Karmaus

Yang³

et al. 2020

IJERPH

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Epidemiological studies have reported the relationship between bisphenol A (BPA) exposure and increased prevalence of asthma, but the mechanisms remain unclear. Here, we investigated whether BPA exposure and DNA methylation related to asthma in children. We collected urinary and blood samples from 228 children (Childhood Environment and Allergic Diseases Study cohort) aged 3 years. Thirty-three candidate genes potentially interacting with BPA exposure were selected from a toxicogenomics database. DNA methylation was measured in 22 blood samples with top-high and bottom-low exposures of BPA. Candidate genes with differential methylation levels were validated by qPCR and promoter associated CpG islands have been investigated. Correlations between the methylation percentage and BPA exposure and asthma were analyzed. According to our findings, MAPK1 showed differential methylation and was further investigated in 228 children. Adjusting for confounders, urinary BPA glucuronide (BPAG) level inversely correlated with MAPK1 promoter methylation (β = −0.539, p = 0.010). For the logistic regression analysis, MAPK1 methylation status was dichotomized into higher methylated and lower methylated groups with cut off continuous variable of median of promoter methylation percentage (50%) while performing the analysis. MAPK1 methylation was lower in children with asthma than in children without asthma (mean ± SD; 69.82 ± 5.88% vs. 79.82 ± 5.56%) (p = 0.001). Mediation analysis suggested that MAPK1 methylation acts as a mediation variable between BPA exposure and asthma. The mechanism of BPA exposure on childhood asthma might, therefore, be through the alteration of MAPK1 methylation. The mechanism of BPA exposure on childhood asthma might, therefore, be through the alteration of MAPK1 methylation.

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“…Possible BPA negative impact on sperm parameters has been investigated in vivo in several recent papers, although data is conflicting as there are papers indicating a negative correlation with sperm concentration and/or total sperm number [89,90], an association with alterations of sperm motility [88] and kinetics parameters [91], negative associations with sperm normal forms [92] or could not find any association with sperm parameters [93].…”

Section: Clinical Data: the Real-life Impact Of Bpa And Phthalates Onmentioning

confidence: 99%

Mechanisms of Testicular Disruption from Exposure to Bisphenol A and Phtalates

Pallotti

Pelloni

Gianfrilli

et al. 2020

JCM

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Great attention has been paid in recent years to the harmful effects of various chemicals that interfere with our natural hormone balance, collectively known as endocrine-disrupting chemicals (EDCs) or endocrine disruptors. The effects on the reproductive system of bisphenol A (BPA) and phthalates have received particular attention: while they have a short half-life, they are so widespread that human exposure can be considered as continuous. Evidence is often limited to the animal model, disregarding the likelihood of human exposure to a mixture of contaminants. Data from animal models show that maternal exposure probably has harmful effects on the male fetus, with an increased risk of urogenital developmental abnormalities. After birth, exposure is associated with changes in the hypothalamic-pituitary-testicular axis, hindering the development and function of the male genital pathways through the mediation of inflammatory mechanisms and oxidative stress. The epidemiological and clinical evidence, while generally confirming the association between reproductive abnormalities and some phthalate esters and BPA, is more contradictory, with wildly different findings. The aim of this review is therefore to provide an update of the potential mechanisms of the damage caused by BPA and phthalates to reproductive function and a review of the clinical evidence currently available in the literature.

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Urinary bisphenol A concentrations are associated with reproductive parameters in young men

Cited by 139 publications

References 49 publications

Alleviating impact of hydroethanolicMurraya koenigiileaves extract on bisphenol A instigated testicular lethality and apoptosis in mice

Alleviating impact of hydroethanolicMurraya koenigiileaves extract on bisphenol A instigated testicular lethality and apoptosis in mice

Bisphenol a Exposure, DNA Methylation, and Asthma in Children

Mechanisms of Testicular Disruption from Exposure to Bisphenol A and Phtalates

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