Urinary bisphenol A concentrations and early reproductive health outcomes among women undergoing IVF

Ehrlich, Shelley; Williams, Paige L.; Missmer, Stacey A.; Flaws, Jodi A.; Ye, Xiaoyun; Calafat, Antònia M.; Petrozza, John C.; Wright, Donald R.; Hauser, Russ

doi:10.1093/humrep/des328

Cited by 210 publications

(146 citation statements)

References 50 publications

(61 reference statements)

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“…To test the hypothesis whether high estradiol levels were associated with worse oocyte, fertilization and peri-implantation parameters and early pregnancy outcomes in IVF, we decided to use similar methodology to establish our cut off to discriminate between the study (high estradiol) and control (lower estradiol) groups. The study outcomes included percentage of normal fertilization {defined as number of 2 pronuclei embryos/ number of matured oocytes (MII); MII oocytes were determined on the day of oocyte retrieval prior to injection for ICSI cycles, and~16-18 h following retrieval for conventional IVF cycles [26]}, proportion of embryos that developed to 6-8 cell stage on day 3 (number of 6-8 cell embryos/total number of 2 pronuclei embryos), positive pregnancy test (positive hCG 12-14 days following embryo transfer), biochemical pregnancy [defined as positive hCG without a gestational sac], implantation rate [defined as number of gestational sacs/number of embryos transferred], clinical pregnancy rate (documented intrauterine pregnancy with fetal heart activity), and first trimester spontaneous miscarriage [defined as pregnancy failure after visualization of intrauterine gestation sac].…”

Section: Methodsmentioning

confidence: 99%

The impact of supraphysiologic serum estradiol levels on peri-implantation embryo development and early pregnancy outcome following in vitro fertilization cycles

Imudia

Goldman

Awonuga

et al. 2013

J Assist Reprod Genet

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Purpose To determine the impact of elevated serum estradiol levels (EE 2 -defined as levels>90th percentile) on the day of hCG administration during IVF on oocyte fertilization, embryo development, implantation, clinical pregnancy and miscarriage rates. Methods A total of 2,995 consecutive IVF cycles in 1,889 patients with non-donor oocyte retrieval resulting in fresh embryo transfer between 1/1/2005 and 12/31/2011 were analyzed. Cycles were stratified by serum E 2 level on the day of hCG administration into those with levels >90th percentile and≤90th percentile. Rates of normal fertilization, embryo development, positive pregnancy test, implantation, clinical pregnancy and spontaneous miscarriage were compared. Results Serum estradiol above the 90th percentile on the day of hCG administration was associated with a significantly lower rate of normal fertilization (68.6±20 vs. 71.6±21, p = 0.02) when compared with patients with a lower serum estradiol threshold. The proportion of embryos that progressed from 2PN to 6-8 cell on day 3 was not different between the two groups. Although rates of positive pregnancy test (55.2 % vs. 57 %), implantation (26.4 % vs. 28.5 %) and clinical pregnancy (45.5 % vs. 49.4 %) were lower in patients with a higher estradiol threshold, these differences were not statistically significant. Similarly, there was no difference in the spontaneous miscarriage rates between the two groups (8.4 % vs. 7.1 %). Conclusions Serum estradiol levels above the 90th percentile on the day of hCG administration is associated with lower oocyte fertilization rate; however, such levels do not impact embryo development, implantation, clinical pregnancy or spontaneous miscarriage rates.

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Section: Methodsmentioning

confidence: 99%

The impact of supraphysiologic serum estradiol levels on peri-implantation embryo development and early pregnancy outcome following in vitro fertilization cycles

Imudia

Goldman

Awonuga

et al. 2013

J Assist Reprod Genet

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“…By contrast, in a study performed by Knez et al (2014), which confirms changes to the semen quality of men with a determined environmental level of BPA, undisrupted development of embryos into blastocysts is described. As against this finding, in women who have undergone IVF, a correlation has been demonstrated between the concentration of BPA in urine and a change to the formation of blastocysts, though a reduced quality of embryos was not recorded (Ehrlich et al 2012). …”

Section: Influences Of Bpa On Reproduction Of Femalesmentioning

confidence: 99%

Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution - a review

Žalmanová¹,

Hošková²,

Nevoral³

et al. 2016

Czech J. Anim. Sci.

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A range of substances that are released into the environment, foodstuffs and drinking water as a result of human activity were originally considered relatively harmless, and it was only later that their adverse effects were discovered. In general the use of such substances is currently restricted, and they are often replaced by other substances. This applies also in the case of a range of endocrine disruptors. These substances have the capacity to disturb the balance of physiological functions of the organism on the level of hormonal regulation, and their pleiotropic spectrum of effects is very difficult to predict. Endocrine disruptors include the currently intensively studied bisphenol A (BPA), a prevalent environmental pollutant and contaminant of both water and foodstuffs. BPA has a significantly negative impact on human health, particularly on the regulation mechanisms of reproduction, and influences fertility. The ever increasingly stringent restriction of the industrial production of BPA is leading to its replacement with analogues, primarily with bisphenol S (BPS), which is not subject to these restrictions and whose impacts on the regulation of reproduction have not yet been exhaustively studied. However, the limited number of studies at disposal indicates that BPS may be at least as harmful as BPA. There is therefore a potential danger that the replacement of BPA with BPS will become one of the cases of regrettable substitution, in which the newly used substances manifest similar or even worse negative effects than the substances which they have replaced. The objective of this review is to draw attention to ill-advised replacements of endocrine disruptors with substances whose effects are not yet tested, and which may represent the same risks for the environment, for the reproduction of males and females, and for human health as have been demonstrated in the case of the originally used substances.

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“…Furthermore, review of the literature did not demonstrate any association with oocyte quality, fertilization rate, embryo development, or ultimately the pregnancy rate for women embarking on IVF treatment (170). Human and animal studies demonstrated impaired steroidogenesis in granulosa cells exposed to BPA (52), and this is borne out by women with higher serum BPA concentrations undergoing IVF treatment whereby they have a lower peak estradiol concentration and reduced oocyte yield (39,94). A recent study of hair mercury concentrations, a marker of dietary fish intake, in women undergoing IVF treatment did not find a relationship between mercury levels and ovarian responsive to stimulation, oocyte fertilization rate, embryo development, and pregnancy rates (376).…”

Section: Pollutantsmentioning

confidence: 99%

Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics

Hart

2016

Physiological Reviews

168

119

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Across the Western World there is an increasing trend to postpone childbearing. Consequently, the negative influence of age on oocyte quality may lead to a difficulty in conceiving for many couples. Furthermore, lifestyle factors may exacerbate a couple's difficulty in conceiving due mainly to the metabolic influence of obesity; however, the negative impacts of low peripheral body fat, excessive exercise, the increasing prevalence of sexually transmitted diseases, and smoking all have significant negative effects on fertility. Other factors that impede conception are the perceived increasing prevalence of the polycystic ovary syndrome, which is further exacerbated by obesity, and the presence of uterine fibroids and endometriosis (a progressive pelvic inflammatory disorder) which are more prevalent in older women. A tendency for an earlier sexual debut and to have more sexual partners has led to an increase in sexually transmitted diseases. In addition, there are several genetic influences that may limit the number of oocytes within the ovary; consequently, by postponing attempts at childbearing, a limitation of oocyte number may become evident, whereas in previous generations with earlier conception this potentially reduced reproductive life span did not manifest in infertility. Environmental influences on reproduction are under increasing scrutiny. Although firm evidence is lacking however, dioxin exposure may be linked to endometriosis, phthalate exposure may influence ovarian reserve, and bisphenol A may interfere with oocyte development and maturation. However, chemotherapy or radiotherapy is recognized to lead to ovarian damage and predispose the woman to ovarian failure.

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Urinary bisphenol A concentrations and early reproductive health outcomes among women undergoing IVF

Abstract: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

Cited by 210 publications

References 50 publications

The impact of supraphysiologic serum estradiol levels on peri-implantation embryo development and early pregnancy outcome following in vitro fertilization cycles

The impact of supraphysiologic serum estradiol levels on peri-implantation embryo development and early pregnancy outcome following in vitro fertilization cycles

Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution - a review

Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics

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