Urinary biopyrrin: a potential inflammatory marker of atopic dermatitis

Chiba, Takahito; Tatematsu, Saori; Nakao, Minoru; Furue, Masutaka

doi:10.1016/j.anai.2013.12.011

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…To the best of our knowledge, this is the first clinical report to analyze the urinary levels of biopyrrins in psoriasis. Increased urinary biopyrrins was reported in atopic dermatitis,[ 23 ] heart failure,[ 24 ] acute myocardial infarction,[ 25 ] asthma[ 26 ] unconjugated hyperbilirubinemia[ 27 ] perinatal stress[ 28 ] and in workers with asbestos exposure. [ 29 ]…”

Section: Discussionmentioning

confidence: 99%

Urinary biopyrrins: A new marker of oxidative stress in psoriasis

et al. 2016

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Background:Psoriasis is a common chronic, relapsing, immune-mediated disease involving skin and joints of genetically predisposed individuals. Oxidative stress has been found to play many important roles in cellular damage and loss of function in a number of tissues and organs and is believed to contribute to the pathogenesis of a variety of diseases. Urinary biopyrrin levels have gained attention as an indicator of oxidative stress.Aim and Objective:To measure urinary biopyrrins excretion as a marker of oxidative stress in psoriasis.Patients and Methods:This case–control study was carried out on 85 subjects; 55 cases with chronic plaque psoriasis and 30 age, gender and body mass index-matched normal subjects as a control group. Urinary biopyrrin levels were measured using enzyme immunoassay.Results:There was a highly significant difference between cases and controls regarding urinary biopyrrins level (P < 0.001). There was significant positive correlation between biopyrrins level and both the age of cases (r = 0.28, P = 0.01) and psoriasis area and severity index score (r = 0.99, P < 0.001).Conclusion:Urinary biopyrrins are increased in patients with psoriasis, and the level is correlated with disease severity. Further large-scale studies involving different ages and different clinical varieties of the disease are needed to expand and validate current findings. The clinical usefulness of antioxidants in psoriasis treatment needs to be evaluated in future research. Furthermore, the value of biopyrrins as biomarkers for monitoring response to therapy needs to be evaluated.

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Section: Discussionmentioning

confidence: 99%

Urinary biopyrrins: A new marker of oxidative stress in psoriasis

et al. 2016

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“…Biopyrrins served as markers of oxidative stress in various studies. − The inherent biological activity of these oxidation products is still not understood. Structurally related tripyrrindiones also suggest interesting chemical properties for this class of molecules .…”

Section: Resultsmentioning

confidence: 99%

A Platform for the Synthesis of Oxidation Products of Bilirubin

Mujawar,

Sevelda,

Madea

et al. 2024

J. Am. Chem. Soc.

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Bilirubin is the principal product of heme catabolism. High concentrations of the pigment are neurotoxic, yet slightly elevated levels are beneficial. Being a potent antioxidant, oxidative transformations of bilirubin occur in vivo and lead to various oxidized fragments. The mechanisms of their formation, intrinsic biological activities, and potential roles in human pathophysiology are poorly understood. Degradation methods have been used to obtain samples of bilirubin oxidation products for research. Here, we report a complementary, fully synthetic method of preparation. Our strategy leverages repeating substitution patterns in the parent tetracyclic pigment. Functionalized ready-to-couple γ-lactone, γ-lactam, and pyrrole monocyclic building blocks were designed and efficiently synthesized. Subsequent modular combinations, supported by metal-catalyzed borylation and cross-coupling chemistries, translated into the concise assembly of the structurally diverse bilirubin oxidation products (BOXes, propentdyopents, and biopyrrins). The discovery of a new photoisomer of biopyrrin A named lumipyrrin is reported. Synthetic bilirubin oxidation products made available in sufficient purity and quantity will support future in vitro and in vivo investigations.

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“…Atopic dermatitis (AD) is a chronic and relapsing eczematous disease generally associated with allergen-induced skin inflammation. Chronic persistent inflammation due to both free radical and inappropriate T helper (Th) cell activation by estrogen decrease is postulated to impair the skin barrier function and to modulate the immunological profile of AD [14, 15]. Clinically, the exacerbation of cutaneous symptoms in AD is known to be associated with menstruation, when estrogen declines [16].…”

Section: Introductionmentioning

confidence: 99%

The Connection between Urinary Equol Levels and the Prevalence of Atopic Dermatitis

Chiba

Nagai

Kohda

et al. 2020

Int Arch Allergy Immunol

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Background: Soy isoflavones and their metabolites such as equol have been associated with a reduced risk of hormone-sensitive tumors and metabolic syndromes. However, individual soy isoflavones and equol levels in atopic dermatitis remain uninvestigated. Objective: The aim of this study is to compare the levels of urinary daidzein, genistein, and equol between atopic dermatitis patients and normal subjects and to examine the correlation between equol concentration and the severity of clinical symptoms. Methods: A cross-sectional study was conducted at Akita University Hospital and Aso Iizuka Hospital in Japan. Fifty patients with confirmed atopic dermatitis diagnosis and 67 healthy controls were recruited. Daidzein, genistein, and equol in urine were measured by using a high-performance liquid chromatography-mass spectrometry system. Results: Urinary equol levels were significantly lower in the atopic dermatitis patients than in the healthy controls (p = 0.002). The difference was particularly noticeable in young people (6–19 years, p < 0.001). No correlations were found between urinary equol levels and the severity of clinical symptoms and laboratory data in the atopic dermatitis patients. Conclusion: Equol levels in childhood might be involved in the development of atopic dermatitis.

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Urinary biopyrrin: a potential inflammatory marker of atopic dermatitis

Cited by 4 publications

References 6 publications

Urinary biopyrrins: A new marker of oxidative stress in psoriasis

Urinary biopyrrins: A new marker of oxidative stress in psoriasis

A Platform for the Synthesis of Oxidation Products of Bilirubin

The Connection between Urinary Equol Levels and the Prevalence of Atopic Dermatitis

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