Urinary biomarkers of oxidative/nitrosative stress in healthy smokers

Campos, Carlos; Guzmán, Rodrigo; López-Fernández, Encarnación; Casado, Ángela

doi:10.3109/08958378.2011.554460

Cited by 40 publications

(31 citation statements)

References 38 publications

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“…The elevated 8-OHdG levels in self-reported smokers reflect that smoking leads the extra DNA damage. These results are consistent with previous studies [22,23,32]. Campos et al [22] found that oxidative stress from cigarette did not appear in former smokers.…”

Section: Discussionsupporting

confidence: 93%

“…On the other hand, Asami et al [21] found the level of 8-OHdG in lung tissues was 1.43-fold higher in smokers than in non-smokers. Campose et al [22] have also found recently higher urinary 8-OHdG levels in healthy cigarette smokers than in non-smokers (10.7 ng/mg creatinine vs. 8.3 ng/mg creatinine). Increased excretion rate of urinary 8-OHdG also has been associated with cigarette smoking, even in lung cancer patients [23].…”

Section: Introductionmentioning

confidence: 92%

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Oxidative Stress of Office Workers Relevant to Tobacco Smoking and Inner Air Quality

Chen

et al. 2014

IJERPH

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Studies have used 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker to detect systemic oxidative DNA damage associated with oxidative stress. However, studies on the association between exposure to tobacco smoking and urinary 8-OHdgG give inconsistent results. Limited studies have estimated the oxidative stress among office workers. This study assessed the association between urinary 8-OHdG and cotinine for office workers. Workers (389) including smokers, ex-smokers and non-smokers from 87 offices at high-rise buildings in Taipei participated in this study with informed consent. Each participant completed a questionnaire and provided a spot urine specimen at the end of work day for measuring urinary 8-OHdG and cotinine. The carbon dioxide (CO2) levels in workers’ offices were also measured. The questionnaire reported socio-demographic characteristics, life styles and allergic history. The urinary 8-OHdG level increased with the cotinine level among participants (Spearmans’ rho = 0.543, p < 0.001). The mean of urinary 8-OHdG and cotinine was 5.81 ± 3.53 μg/g creatinine and 3.76 ± 4.06 μg/g creatinine, respectively. Comparing with non-smokers, the adjusted odds ratio (OR) of having urinary 8-OHdG greater than the median level of 4.99 μg/g creatinine was 5.30 (95% confidence intervals (CI) = 1.30–21.5) for current smokers and 0.91 (95% CI = 0.34–2.43) for former smokers. We also found workers exposed to 1,000 ppm of CO2 at offices had an adjusted OR of 4.28 (95% CI = 1.12–16.4) to have urinary 8-OHdG greater than 4.99 μg/g creatinine, compared to those exposed to indoor CO2 under 600 ppm. In conclusion, urinary 8-OHdG could represent a suitable marker for measuring smoking and CO2 exposure for office workers.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 92%

Oxidative Stress of Office Workers Relevant to Tobacco Smoking and Inner Air Quality

Chen

et al. 2014

IJERPH

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“…Elevated levels of isoprostane 8,12-iso-iPF2α (iPF2α), a specific marker of lipid peroxidation, have been demonstrated in living adults with DS [13]. Recently, evaluation of some biomarkers of oxidative/nitrosative stress in the urine from adults compared with adolescent DS subjects demonstrated that advanced glycation end products, dityrosine, H 2 O 2 and nitrite/nitrate could be considered as OS biomarkers in DS in contrast to other markers, such as 8-OHG, 15-F(2t)-IsoP and TBARS, which gave contrasting results [14]. However, additional studies on large populations are needed to confirm the reproducibility of these results.…”

Section: Is Os the Bridge Between Ds And Alzheimer's Disease?mentioning

confidence: 99%

The identification of protein biomarkers for oxidative stress in Down syndrome

Perluigi

Butterfield²

2011

Expert Review of Proteomics

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“…Data regarding cigarette smoking is controversial. While some studies showed an association between cigarette smoking and 8-OHdG levels (Campos et al, 2011;Chiang et al, 2012), others failed to show such an association (Feng et al, 2006). Previous studies revealed higher levels of 8-OHdG in the lung, liver, and heart of mice exposed to cigarette smoke (Howard et al, 1998;Thaiparambil et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Assessment of genotoxicity of waterpipe smoking using 8-OHdG biomarker

Azab¹,

Khabour²,

Alzoubi³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Waterpipe tobacco smoking is increasing in popularity, particularly among young adults. This popularity is related to the lack knowledge regarding the health effects of waterpipe smoking. In this study, we examined the genotoxicity of waterpipe smoking using an 8-hydroxy deoxyguanosine (8-OHdG) assay. Genotoxicity was evaluated in the saliva, urine, and serum of 66 waterpipe adult smokers and 46 healthy nonsmokers. The level of addiction to waterpipe smoking was evaluated using the Lebanon Waterpipe Dependence Scale-11. Levels of 8-OHdG in the samples were measured using commercially available enzyme-linked immunosorbent assays. Levels of 8-OHdG in the saliva (52,430 ± 2923 vs 48,430 ± 4189 pg/mL), urine (2815 ± 312 vs 2608 ± 180 pg/mL), and serum (19,720 ± 202 vs 19,670 ± 254 pg/mL) were similar between waterpipe smokers and nonsmokers (P > 0.05). In addition, no correlations were found between dependence M. Azab et al. 9556©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 9555-9561 (2015) score and levels of 8-OHdG in all sample types. In conclusion, 8-OHdG is not a good biomarker for genotoxic effect of waterpipe smoking.

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Urinary biomarkers of oxidative/nitrosative stress in healthy smokers

Cited by 40 publications

References 38 publications

Oxidative Stress of Office Workers Relevant to Tobacco Smoking and Inner Air Quality

Oxidative Stress of Office Workers Relevant to Tobacco Smoking and Inner Air Quality

The identification of protein biomarkers for oxidative stress in Down syndrome

Assessment of genotoxicity of waterpipe smoking using 8-OHdG biomarker

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