Urinary biomarkers in bladder cancer: A review of the current landscape and future directions

Abstract

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The role of URO17™ biomarker to enhance diagnosis of urothelial cancer in new hematuria patients—First European Data

“…It is important to highlight the significance of these results in comparison to other urinary biomarkers for bladder cancer 5,19,29–33 . We have confirmed that URO17™ has one of the highest sensitivity and specificity reported in identifying bladder cancer through noninvasive urine samples.…”

“…It is important to highlight the significance of these results in comparison to other urinary biomarkers for bladder cancer. 5,19,[29][30][31][32][33] We have confirmed that URO17™ has one of the highest sensitivity and specificity reported in identifying bladder cancer through non- and expands the application of URO17™ to hematuria patients. In the end, combinations of biomarkers may be the key to providing the most effective investigation where the application of URO17™…”

“…Furthermore, the data also showed that URO17™ test was able to detect BC in renal pelvis that was missed by urine cytology and cystoscopy which suggest that URO17™ test could be used to augment and increase the accuracy of cystoscopy and traditional urine cytology in monitoring patients for recurrence. 5,25 5 …”

“…Unfortunately, 37% of new cases are found to have muscle‐invasive malignancies at the time of diagnosis which can result in a 60% 5 year survival rate, dropping to 4% for metastatic malignancy 4 . However, new developments in the management of both nonmetastatic and metastatic disease continue with improvement in survival 4,5 . This emphasizes despite of the new developments is on the importance of early diagnosis and timely treatment, being the clear clinical priority.…”

Can new immunoassay techniques improve bladder cancer diagnostics With protein biomarkers?

“…This is probably due to the fact that new biomarkers demonstrating high efficiency in research laboratories are not sufficiently reliable when used for screening a large number of patients. The relevance of the topic is confirmed by a large number of articles and reviews published in recent years, for example ( Maas et al, 2019 ; Ng et al, 2020 ; Chakraborty et al, 2019 ; Kim et al, 2020 ; Batista et al, 2020 ; Faiena et al, 2019 ; Matuszczak and Salagierki, 2020 ; Miyamoto et al, 2020 ; Carando et al, 2021 ). The authors are constantly systematizing and analyzing new data to select biomarkers for both diagnosing BC and monitoring treatment response.…”