Urinary biomarkers as indicator of chronic inflammation and endothelial dysfunction in obese adolescents

Singh, Ruchi; Verma, Arushi; Aljabari, Salim; Vasylyeva, Tetyana L.

doi:10.1186/s40608-017-0148-2

Cited by 15 publications

(31 citation statements)

References 35 publications

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“…[15][16][17] The increase in the body weight and abdominal fat increases oxidative stress, inflammation processes, dyslipidemia, hypertension, insulin resistance/diabetes, cardiovascular diseases, and the complications of these conditions that are directly linked to the morbidity and mortality. [11,[18][19] On the other hand, the atherogenic process is a phenomenon that occurs slowly and may start years before the clinical manifestation. For this reason, many researchers are motivated to study and develop new therapeutic approaches, such as the use of plants that may improve the risk factors before the atherosclerotic process becomes an irreversible condition.…”

Section: Discussionmentioning

confidence: 99%

“…The release of inflammatory cytokines and other markers such as Interleukin-1β (IL-1 β ), IL-6, Tumor Necrosis Factor-α, and C-reactive protein may also be reversible. [11,[20][21][22] The Elevated Plus Maze (EPM) test is widely used to investigate the psychological bases of anxiety. Usually an animal without any treatment tends to remain for a longer time in the closed arms that represents an exposition to naturally threatening situations, which in the The presence of substances that reduce anxiety makes the animal feel calmer and consider the environment less threatening.…”

Section: Discussionmentioning

confidence: 99%

“…The use of healthy foods as seeds may help in this approach. [11][12] www.wjpr.net Vol 6, Issue 05, 2017. 54…”

Section: Introductionmentioning

confidence: 99%

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Dypteryx Alata Vogel Seeds May Improve Anthropometric and Behavioral Profile of Wistar Rats

Barbalho¹

2017

WJPR

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Dipteryx alata Vogel (DA), popularly known as baru, is a native tree from the Brazilian Cerrado and belongs to the family Fabaceae. It possesses a seed (almond), covered by a sweet yellow pulp and a brown shell that is rich in proteins, with an important amount of essential amino acids, unsaturated fatty acids, mainly oleic acid, fiber, vitamins and minerals. The objective of this research was to investigate the effects of baru almonds on the anthropometric profile and behavioral of Wistar rats. Animals weighting 180g-220g were divided randomly in G1 (n=10) that was fed water and rat food ad libitum and G2 (n=10) that was fed water and rat food supplemented with DA 40% ad libitum for 40 days. Our results showed that Dipteryx alata reduce food intake and may help prevent the increase in body weight and deposition of visceral fat as well as it may help in the reduction of the anxiety behavior. Baru seeds may play an important role in the agro-

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Dypteryx Alata Vogel Seeds May Improve Anthropometric and Behavioral Profile of Wistar Rats

Barbalho¹

2017

WJPR

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“…Ethnicity and sample size differences may have also contributed to the different results. The aforementioned study by Singh et al (2017) investigating urinary biomarkers in adolescents found a tendency for IL-6 to be higher in the urine of obese subjects but this increase was not significant. However, a significant positive correlation was reported between urinary IL-6 and TNF-α, another marker that was significantly elevated in obese adolescents (Singh et al, 2017).…”

Section: Interleukin-6 (Il-6)mentioning

confidence: 89%

“…Similarly, serum TNF-α is significantly increased in obese children compared to controls (Giordano et al, 2011). A recent study investigating urinary biomarkers in relation to BMI status among adolescents aged 10 to 20 years found that urinary TNF-α was significantly elevated in those who were obese (Singh et al, 2017). Increased urinary TNF-α may therefore be a potential noninvasive way of detecting obesity-related inflammation.…”

Section: Tumour Necrosis Factor-α (Tnf-α)mentioning

confidence: 99%

Infant body composition as a predictor of childhood obesity, cardiovascular risk and inflammatory markers

Ratnasingham¹

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Background Childhood obesity is a growing epidemic associated with increased cardiometabolic disease risk in later life. Early detection and effective intervention are critical for preventing later obesity onset. Early life plays a key role in programming the development of later diseases. While birth weight is associated with poor health outcomes in later life, early body composition (fat mass [FM] vs. fat-free mass [FFM]) may be a better predictor. Aims The overarching aim of this study was to determine whether infant body composition is associated with later adverse health risk in childhood. Specifically, this study aimed to determine: (1) whether infant body composition is a better predictor of childhood obesity/cardiovascular risk/inflammatory markers than birth weight; and if so, (2) which infant body composition factors best predict childhood obesity/cardiovascular risk/inflammatory markers; and (3) what other early life and childhood factors are associated with childhood obesity/cardiovascular risk/inflammatory markers. It was hypothesised that increased infant adiposity would be a better predictor of later adverse health risk in childhood than birth weight. Methods This was an observational follow-up study of 131 children recruited as newborns at the Royal Brisbane and Women's Hospital (RBWH) between 2007 and 2010. Body composition had previously been measured by air displacement plethysmography (ADP) using the PEA POD ® Infant Body Composition System at four different timepoints during infancy: birth, 6 weeks, 3 months and 4.5 months of age. Maternal risk factors (e.g. pre-pregnancy body mass index [BMI] and gestational diabetes mellitus [GDM]) and infant feeding information were also recorded. During the childhood follow-up visit at 8 to 11 years of age, body composition was measured by ADP using the BOD POD ® Body Composition System to assess obesity. Childhood cardiovascular risk was assessed using multiple markers: carotid intima-media thickness (cIMT), retinal vasculature parameters (mainly arteriole-to-venule ratio [AVR]) and blood pressure (systolic blood pressure [SBP] and diastolic blood pressure [DBP]). Urine samples were collected and assayed for four inflammatory markers: tumour iii necrosis factor-α (TNF-α), interleukin-6 (IL-6), α1-acid glycoprotein (AGP) and endothelin-1 (ET-1). Potential confounding factors including diet, physical activity and socioeconomic status (SES) were also recorded. Backward stepwise multiple regression analyses were used to identify significant predictors of childhood outcome variables. Statistical significance was accepted at p < 0.05. Results There was no association between childhood percentage fat (%Fat) and either birth weight or birth weight z-score in this cohort. Higher %Fat at 6 weeks was a significant predictor of increased childhood %Fat, as were higher maternal pre-pregnancy BMI and earlier exposure to formula feeding. For every additional 1% in %Fat at 6 weeks, childhood %Fat increased by 0.4%. For every 2.5 kg/m 2 increase in maternal pre-pregnancy...

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Tumor Necrosis Factor (TNF) α, Endothelin (ET) 1 and α1-Acid Glycoprotein (AGP) as Potential Urine and Serum Markers of Metabolic Complications in Psoriasis?

Nowowiejska

Baran

Hermanowicz

et al. 2023

Dermatol Ther (Heidelb)

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Introduction Psoriasis, one of the most frequent dermatoses, strongly associated with metabolic disorders which increase patients’ comorbidity and mortality. Hence, it is essential to look for markers of such complications. Our aim was to assess the clinical utility of urinary tumor necrosis factor alpha (TNFα), endothelin 1 (ET-1) and α1-acid glycoprotein (α1AGP) as well as their serum concentrations as markers of metabolic complications in psoriatics, and to examine the relations of these markers to clinical and demographic parameters. Methods The study involved 60 patients with plaque psoriasis and 30 volunteers without skin diseases (the control group). Serum and urinary concentrations of TNFα, ET-1 and α1AGP were measured by ELISA. Psoriasis severity was assessed using the psoriasis activity and severity index (PASI). Routine laboratory investigations were additionally performed. Results All serum markers were significantly higher in the patients compared to the controls. TNFα was undetectable in the urine in half of the patients. The urinary ET-1/creatinine concentration ratio was significantly lower in the psoriatics than the controls, whereas the absolute urinary α1AGP was significantly higher and the α1AGP/creatinine ratio was insignificantly different. There was no correlation between serum or urinary markers and PASI. All serum markers were higher in patients with psoriasis lasting less than 15 years. Conclusions Serum TNFα, ET-1 and α1AGP seem to be useful biomarkers of metabolic syndrome in psoriatics. ET-1 could perhaps become a urinary marker of metabolic disorders in psoriatics, but further studies are required to confirm that a decreased ET-1 concentration in urine is a reliable predictive tool. Increased urinary α1AGP also requires more in-depth research as a potential marker. TNFα urine assessment does not seem to be useful for screening for metabolic disorders in psoriatics. Serum or urinary TNFα, ET-1 and α1AGP do not seem to be associated with psoriasis severity or duration.

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Urinary biomarkers as indicator of chronic inflammation and endothelial dysfunction in obese adolescents

Cited by 15 publications

References 35 publications

Dypteryx Alata Vogel Seeds May Improve Anthropometric and Behavioral Profile of Wistar Rats

Dypteryx Alata Vogel Seeds May Improve Anthropometric and Behavioral Profile of Wistar Rats

Infant body composition as a predictor of childhood obesity, cardiovascular risk and inflammatory markers

Tumor Necrosis Factor (TNF) α, Endothelin (ET) 1 and α1-Acid Glycoprotein (AGP) as Potential Urine and Serum Markers of Metabolic Complications in Psoriasis?

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