Urinary biochemical profile of patients with ureteric calculi in Jodhpur region (north western India)

Singh, P. P.; Pendse, A. K.; Rathore, V.; Dashora, P. K.

doi:10.1007/bf00261966

Cited by 11 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high incidence of calcium oxalate stones in our region may be because of its hot climate, oxalate-rich diet, and decreased fluid intake. [ 20 21 ] On subgroup analysis based on the patient's age, we observed that the proportion of calcium oxalate stone was increasing whereas that of uric acid, struvite, and cystine was decreasing with age, and this trend was similar for all whether it was renal, ureteric, or vesical calculus. Gabrielsen et al .…”

Section: Discussionmentioning

confidence: 91%

Spectrum of urinary stone composition in Northwestern Rajasthan using Fourier transform infrared spectroscopy

et al. 2018

View full text Add to dashboard Cite

Introduction:The aim of this study was to evaluate the chemical composition of urinary stones and pattern of changes according to the patient's age in Northwestern Rajasthan using Fourier transform infrared (FTIR) spectroscopy.Materials and Methods:A prospective study of 1005 urolithiasis patients was carried out in two tertiary care centers from September 2012 to September 2016. Chemical composition of urinary stones was analyzed using FTIR spectroscopy, and a subgroup study based on the patient's age was done (8–12 years – Group A, 13–18 years – Group B, and >18 years – Group C).Results:Out of 1005 patients, 59 were in Group A, 104 in Group B, and 842 in Group C. Male predominance was found in all age groups. Mixed composition stones were much more common than pure one (74.83% vs. 25.17%). Overall, combination of calcium oxalate monohydrate with dihydrate was the most common composition (58.0%). Calcium oxalate was the predominant chemical composition in 91.54% of stones, followed by uric acid in 4.28%, struvite in 2.29%, calcium phosphate in 1.49%, and cystine in 0.4%. The proportion of calcium oxalate stone was increasing while that of struvite, uric acid, and cystine stone was decreasing with age. Most of the vesical calculi in pediatric age group (Group A; 8–12 years) patients were made up of combination of struvite, calcium phosphate, and uric acid. A total of 85.11% of staghorn calculi were of oxalates.Conclusion:In Northwestern Rajasthan, calcium oxalate is the most common composition of urinary stones in all age groups. Mixed stones are more common than pure ones. The incidence of calcium oxalate stone increases while that of struvite, uric acid, and cystine stone decreases with age.

show abstract

Section: Discussionmentioning

confidence: 91%

Spectrum of urinary stone composition in Northwestern Rajasthan using Fourier transform infrared spectroscopy

et al. 2018

View full text Add to dashboard Cite

show abstract

“…This fi nding is also in contrast to Western studies where staghorn stones more often are composed of struvite. The predominance of calcium oxalate stones also has been shown in various other studies [ 15,16 ] . Older studies from the northwestern region of India revealed a higher proportion of struvite stones [ 7,10 ] .…”

Section: Compositionmentioning

confidence: 79%

“…In a study from Rajasthan, though magnesium intake was normal in both normal subjects and stone formers, the mean excretion of magnesium was lower than normal in all the groups, suggesting its defective absorption in this population [ 16 ] . Lower concentration of urinary magnesium was found in stone formers from Chandigarh, suggesting its inhibitory role in urolithiasis [ 46 ] .…”

Section: Magnesiummentioning

confidence: 98%

Epidemiology of Stone Disease in Northern India

Ganesamoni¹,

Singh²

2012

Urolithiasis

View full text Add to dashboard Cite

Urinary stone disease is highly prevalent in North India, a part of the stone belt in Asia. Two distinct "stone belts" have been identi fi ed in the northwestern region (NW); stone disease is less common in the southern and eastern regions. Calcium oxalate (CaOx) comprises a greater proportion of stones than seen in Western studies. While struvite stones were common in older series from NW, CaOx remains the predominant stone now, even in staghorns. First-degree relatives of stone formers are at higher risk of developing urolithiasis and have signi fi cantly higher urinary calcium excretion as compared to the spouses of the stone formers. Urinary tract infection was found to be one of the principal risk factors of urinary stones in North India. Metabolic acidosis is present in up to 45.2 % of stone formers as compared with 10.8 % in non-stone formers. Only dietary calcium correlated signi fi cantly with serum and urine calcium in stone formers. Stone patients from North India were shown to have a signi fi cantly higher intake of dairy products such as curd and cheese as compared to nonstone cases. Lower concentrations of urinary magnesium, copper, and manganese were noted in stone formers. Zinc excretion was signi fi cantly higher in stone formers. A signi fi cantly higher urinary urate excretion has been shown among stone formers from Delhi and Rajasthan.

show abstract

“…[12] Ureteric stone analysis done in Jodhpur also reported a similar finding. [13] Hypercalciuria and hyperparathyroidism are the risk factors for calcium stone formation. Excessive consumption of Oxalate containing foods or excessive absorption of oxalate in enteric diseases or ileojejunal surgery or Vitamin C supplementation [14] contributes to oxalate stone formation.…”

Section: Discussionmentioning

confidence: 99%

Significance of Chemical Composition Analysis in Urolithiasis

2020

IJPHRD

View full text Add to dashboard Cite

Introduction: Urolithiasis is the formation of stones in the urinary tract. Between 1% and 15% of people globally are affected by kidney stones at some point in their lives. Knowledge of chemical composition of Renal stones may be helpful in clinical management of patients as well as in reducing risk of prevalence and recurrence of stones in this region. Aims and Objectives:To analyse the chemical composition of Urinary tract stones. Material and Method:The present study included 100 uroliths obtained by surgical intervention of Urolithiasis patients diagnosed at MM Institute of Medical Sciences, MMDU , Mullana from August 2018 to October 2019. The powdered form was qualitatively analyzed for their chemical composition adopting standard methods. Results:In the present study, out of total 100 patients, the incidence of urolithiasis was more in males (72%) compared to females(28%).Distribution of stones based on their location, showed a high incidence of stones in the ureter (42%), followed by Bladder (26%) and Urethra (19%). Calcium oxalate was the most predominant chemical composition in the stones analyzed (63%), followed by Uric acid (18%). Calcium carbonate, Calcium phosphate and Magnesium Ammonium phosphate were predominant in 8%, 6% and 5% of stones respectively. Conclusion:Analysis of the chemical composition of stones and knowledge of its etiology will help in improving the management of patients with Urolithiasis.

show abstract

Urinary biochemical profile of patients with ureteric calculi in Jodhpur region (north western India)

Cited by 11 publications

References 21 publications

Spectrum of urinary stone composition in Northwestern Rajasthan using Fourier transform infrared spectroscopy

Spectrum of urinary stone composition in Northwestern Rajasthan using Fourier transform infrared spectroscopy

Epidemiology of Stone Disease in Northern India

Significance of Chemical Composition Analysis in Urolithiasis

Contact Info

Product

Resources

About