Urinary benzene metabolite and insulin resistance in elderly adults

Choi, Yu Hyeon; Kim, Jin Hee; Lee, Boeun; Hong, Yun–Chul

doi:10.1016/j.scitotenv.2014.02.121

Cited by 28 publications

(30 citation statements)

References 51 publications

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“…Male mice exposed to benzene developed hyperglycemia and hyperinsulinemia followed by elevated expression of hepatic gluconeogenic and lipid metabolism genes. The association between benzene exposure and insulin resistance was reported in a few epidemiological and rodent studies [23,26,27,43,55,56]. Studies in humans found that the elimination of benzene is slower in women than in men, likely due to the higher percentage and distribution of body fat tissue [57].…”

Section: Discussionmentioning

confidence: 95%

“…Studies in humans found that the elimination of benzene is slower in women than in men, likely due to the higher percentage and distribution of body fat tissue [57]. On the other hand, an association between urinary benzene metabolite levels and insulin resistance in elderly adults demonstrated a stronger relationship in men than in women [23]. Furthermore, sex differences were observed upon occupational benzene exposure, particularly effects related to biotransformation of benzene to t,t-MA and hematological parameters [58].…”

Section: Discussionmentioning

confidence: 99%

“…T2DM has become a global pandemic resulting in a reduced quality of life due to comorbidity and premature mortality [20][21][22]. A recent study demonstrated an association between levels of urinary benzene metabolites in elderly adults living in polluted areas and insulin resistance (IR) [23]. Additionally, benzene exposure and presence of urinary benzene metabolites are associated with increased cardiovascular risk and dyslipidemia in both smokers and nonsmokers, suggesting that benzene may be linked to cardiovascular injury, even in the absence of exposure to other tobacco smoke constituents [16].…”

Section: Introductionmentioning

confidence: 99%

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Acarbose Protects From Central and Peripheral Metabolic Imbalance Induced by Benzene Exposure

Debarba

Mulka

Lima

et al. 2020

Preprint

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Abbreviations:CNS, central nervous system; ARC, arcuate nucleus of the hypothalamus; DMH, dorsomedial hypothalamic nucleus; LHA, lateral hypothalamus; PVH, paraventricular hypothalamic nucleus; AbstractBenzene is a well-known human carcinogen that is one of the major components of air pollution. Sources of benzene in ambient air include cigarette smoke, e-cigarettes vaping and evaporation of benzene containing petrol processes. While carcinogenic effects of benzene exposure have been well studied, less is known about metabolic effects of benzene exposure.We show that chronic exposure to benzene at low levels induces severe metabolic imbalance in a sex-specific manner, which is associated with hypothalamic inflammation and endoplasmic reticulum (ER) stress. Benzene exposure rapidly activates hypothalamic ER stress and neuroinflammatory responses in male mice, while pharmacological inhibition of ER stress response by inhibiting IRE1α-XBP1 pathway significantly alleviates benzene-induced glial inflammatory responses. Additionally, feeding mice with Acarbose, a clinically available anti-diabetes drug, protected against benzene induced central and peripheral metabolic imbalance. Acarbose imitates the slowing of dietary carbohydrate digestion, suggesting that choosing a diet with a low glycemic index might be a potential strategy for reducing the negative metabolic effect of chronic exposure to benzene for smokers or for people living/working in urban environments with high concentrations of exposure to automobile exhausts.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acarbose Protects From Central and Peripheral Metabolic Imbalance Induced by Benzene Exposure

Debarba

Mulka

Lima

et al. 2020

Preprint

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“…Nevertheless, our results have wide implications as they suggest that exposure to benzene from any source could increase CVD risk. While a few studies have suggested a relationship between benzene exposure and insulin resistance or hypertension, these results have not been confirmed in animal models, or in well-controlled studies [ 45 , 46 ]. Because benzene is a ubiquitous pollutant, further evaluation of its cardiovascular effects could inform exposure avoidance guidelines and regulatory policy to limit emissions by automobiles and industrial processes or to regulate tobacco products.…”

Section: Discussionmentioning

confidence: 99%

Benzene exposure is associated with cardiovascular disease risk

et al. 2017

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Benzene is a ubiquitous, volatile pollutant present at high concentrations in toxins (e.g. tobacco smoke) known to increase cardiovascular disease (CVD) risk. Despite its prevalence, the cardiovascular effects of benzene have rarely been studied. Hence, we examined whether exposure to benzene is associated with increased CVD risk. The effects of benzene exposure in mice were assessed by direct inhalation, while the effects of benzene exposure in humans was assessed in 210 individuals with mild to high CVD risk by measuring urinary levels of the benzene metabolite trans,trans-muconic acid (t,t-MA). Generalized linear models were used to assess the association between benzene exposure and CVD risk. Mice inhaling volatile benzene had significantly reduced levels of circulating angiogenic cells (Flk-1+/Sca-1+) as well as an increased levels of plasma low-density lipoprotein (LDL) compared with control mice breathing filtered air. In the human cohort, urinary levels of t,t-MA were inversely associated several populations of circulating angiogenic cells (CD31+/34+/45+, CD31+/34+/45+/AC133–, CD34+/45+/AC133+). Although t,t-MA was not associated with plasma markers of inflammation or thrombosis, t,t-MA levels were higher in smokers and in individuals with dyslipidemia. In smokers, t,t-MA levels were positively associated with urinary metabolites of nicotine (cotinine) and acrolein (3-hydroxymercapturic acid). Levels of t,t-MA were also associated with CVD risk as assessed using the Framingham Risk Score and this association was independent of smoking. Thus, benzene exposure is associated with increased CVD risk and deficits in circulating angiogenic cells in both smokers and non-smokers.

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“…Covariates to be controlled were identified a priori, based on biological consideration and the literature review. 25–27 …”

Section: Methodsmentioning

confidence: 99%

Sex-dependent and body weight-dependent associations between environmental PAHs exposure and insulin resistance: Korean urban elderly panel

Choi

Kim

Hong

2015

J Epidemiol Community Health

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BackgroundThe prevalence of metabolic diseases rises rapidly with an ageing population. Recent studies suggest the potential involvement of environmental chemicals in insulin resistance (IR) that plays a core role in the development of metabolic diseases. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous components of outdoor and indoor air pollution. The influence of PAHs on IR may differ depending on sex and weight.ObjectivesWe examined the association between exposure to environmental PAHs and IR in Korean urban elderly adults controlling for major risk factors that contribute to an increase in IR.MethodsBetween 2008 and 2010, PAH metabolite levels (urinary 1-hydroxypyrene (1-OHP)) and the homoeostatic model assessment index (HOMA-IR) were repeatedly measured in 502 adults aged ≥60 years. Linear mixed effect models were fit to evaluate the associations of 1-OHP concentration with HOMA-IR. Subgroups were modelled by sex and weight.ResultsAfter adjusting for sociodemographics, air pollution and metabolic disease status, the highest (vs lowest) quartile of 1-OHP was associated with an 0.57 (95% CI 0.10 to 1.04) increase in the HOMA-IR score (p trend=0.037). When stratified by sex, women presented a significantly dose-dependent trend of 1-OHP with HOMA-IR (p trend=0.013), whereas no association was observed in men (p trend=0.904). When further stratified by weight (body mass index ≥25 vs <25 kg/m2), a significant association was found only in overweight women (p trend=0.023).ConclusionsOur results suggest that environmental exposure to PAHs is associated with increased IR in elderly adults and that the association may be limited to overweight women.

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Urinary benzene metabolite and insulin resistance in elderly adults

Cited by 28 publications

References 51 publications

Acarbose Protects From Central and Peripheral Metabolic Imbalance Induced by Benzene Exposure

Acarbose Protects From Central and Peripheral Metabolic Imbalance Induced by Benzene Exposure

Benzene exposure is associated with cardiovascular disease risk

Sex-dependent and body weight-dependent associations between environmental PAHs exposure and insulin resistance: Korean urban elderly panel

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