Urinary angiotensinogen in pediatric urinary tract infection

Mayumi, Reina; Murano, Yayoi; Yokota, Reina; Nakao, Atsushi; Miyazaki, Nao; Hara, Taichi; Mizutani, Akira; Hayashi, Kuniyoshi; Sakurai, Yumiko; Shoji, Hiromichi; Nakazawa, Tomoyuki; Shimizu, Toshiaki

doi:10.1111/ped.13890

Cited by 3 publications

(3 citation statements)

References 15 publications

(47 reference statements)

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“…As a result, patients suffer more pains and difficulties in treatment. The risk of urinary tract infection (Mayumi et al 2019;Net et al 2018) will rise, disadvantaging the prognosis. As a common treatment of UR, indwelling catheter may lead to urinary tract infection while extubation difficulties are expected in some patients.…”

Section: Discussionmentioning

confidence: 99%

Low-frequency Electrical Stimulation Combined with Preventative Pelvic Floor Muscle Exercises and Knowledge-attitude-practice Model in Women with Urinary Retention after a Pelvic Surgery

Liu¹,

Guo²,

Kang³

et al. 2021

JSM

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This study was to explore the efficacy of low-frequency electrical stimulation (LFES) combined with preventative pelvic floor muscle exercises (PPFME) and knowledge-attitude-practice model (KAP model) in women with urinary retention (UR) after a pelvic surgery and the effect on quality of life (QOL). The clinical data of 153 women hospitalized with UR after a pelvic surgery from January 2015 to June 2019 were retrospectively analyzed and divided into the Control Group (CG, n=45, LFES+PPFME) and the Study Group (SG, n=108, LFES+PPFME+KAP model) according to the different treatment methods. Following indicators were compared between the two groups: clinical efficacy, time to first urination, urine output, rate of extubation in 3D, rate of repeated intubation, urodynamic indicators before and after treatment, postvoid residual (PVR), bladder compliance (BC), maximal flow rate (Q-max), pressure of detrusor at Pdet-Q-max (Pdet-Q-max), changes in QOL, incidence of urinary tract infection, and length of stay (LOS). Compared to CG, SG showed higher overall response rate (ORR) and rate of extubation in 3D, shorter time to first urination, higher urine output, lower rate of repeated intubation and incidence of urinary tract infection, and shorter LOS (P<0.05); both groups achieved improvements in urodynamic indicators and QOL score after treatment (P<0.05); the urodynamic indicators and QOL score in SG were better than the CG’s (P<0.05). LFES combined with PPFME and KAP model is effective in treating women with UR after a pelvic surgery by efficaciously improving patients’ urination and QOL.

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Section: Discussionmentioning

confidence: 99%

Low-frequency Electrical Stimulation Combined with Preventative Pelvic Floor Muscle Exercises and Knowledge-attitude-practice Model in Women with Urinary Retention after a Pelvic Surgery

Liu¹,

Guo²,

Kang³

et al. 2021

JSM

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“…Another biomarker that reflects the significant early steps in disease pathogenesis of necrotizing enterocolitis (NEC) is I-FABP [26][27][28][29]. AGT is another biomarker extensively reported in the pediatric population to evaluate renal development and injury [30,31].…”

Section: Significance Statementmentioning

confidence: 99%

“…For instance, the role of uromodulin (UMOD) and urinary neutrophil gelatinase-associated lipocalin (NGAL) in acute kidney injury (AKI) (18)(19)(20). Another biomarker that re ects the signi cant early steps in disease pathogenesis of necrotizing enterocolitis (NEC) is I-FABP(21-24) (AGT) is another biomarker extensively reported in the pediatric population to evaluate renal development and injury (25,26) In the present study, we employed a quantitative proteomics approach to identify urinary biomarkers to detect early brain injury in asphyxiated neonates with different stages of HIE-Mild (HIE-1), Moderate (HIE-2), and Severe (HIE-3). Our analysis revealed early biomarkers like Uromodulin (UMOD), Apolipoprotein-A2 (APOA2) for HIE-1 and also differential or severity biomarkers like Fatty Acid Binding Protein 1 (FABP1), Apolipoprotein-M (APOM), Parkinsonism Associated Deglycase (PARK7), Osteopontin (SPP1) for all the three HIE stages.…”

Section: Introductionmentioning

confidence: 99%

A comparative proteomic analysis for non‐invasive early prediction of hypoxic‐ischemic injury in asphyxiated neonates

Gurtoo,

Karthikkeyan,

Behera

et al. 2023

Proteomics Clinical Apps

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AimHypoxic Ischemic Encephalopathy (HIE) is one of the principal causes of neonatal mortality and long‐term morbidity worldwide. The neonatal signs of mild cerebral injury are subtle, making an early precise diagnosis difficult. Delayed detection, poor prognosis, and lack of specific biomarkers for the disease are increasing mortality rates. In this study, we intended to identify specific biomarkers using comparative proteomic analysis to predict the severity of perinatal asphyxia so that its outcome can also be prevented.Experimental DesignA case‐control study was conducted on 38 neonates, and urine samples were collected within 24 and 72 h of life. A tandem mass spectrometry‐based quantitative proteomics approach, followed by validation via sandwich ELISA, was performed.ResultsThe LC‐MS/MS‐based proteomics analysis resulted in the identification of 1201 proteins in urine, with 229, 244, and 426 being differentially expressed in HIE‐1, HIE‐2, and HIE‐3, respectively. Axon guidance, Diseases of programmed cell death, and Detoxification of reactive oxygen species pathways were significantly enriched in mild HIE versus severe HIE. Among the differentially expressed proteins in various stages of HIE, we chose to validate four proteins – APP, AGT, FABP1, and FN1 – via sandwich ELISA. Individual and cumulative ROC curves were plotted. AGT and FABP1 together showed high sensitivity, specificity, and accuracy as potential biomarkers for early diagnosis of HIE.ConclusionEstablishing putative urinary biomarkers will facilitate clinicians to more accurately screen neonates for brain injury and monitor the disease progression. Prompt treatment of neonates may reduce mortality and neurodevelopmental impairment.

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A comparative proteomic analysis for non-invasive early prediction of hypoxic-ischemic injury in asphyxiated neonates

Gurtoo

Karthikkeyan

Behera

et al. 2023

Preprint

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Aim: Hypoxic Ischemic Encephalopathy (HIE) is one of the principal causes of neonatal mortality and long-term morbidity worldwide. The neonatal signs of mild cerebral injury are subtle, making an early precise diagnosis difficult. Delayed detection, poor prognosis, and lack of specific biomarkers for the disease are increasing mortality rates. In this study, we intended to identify specific biomarkers using comparative proteomic analysis to predict the severity of perinatal asphyxia so that its outcome can also be prevented. Experimental Design: A case-control study was conducted on 38 neonates, and urine samples were collected within 24 and 72 hours of life. A tandem mass spectrometry-based quantitative proteomics approach followed by validation via sandwich ELISA was performed. Results: The LC-MS/MS-based proteomics analysis resulted in the identification of 1,201 proteins in urine with 229, 244 and 426 being differentially expressed in HIE-1, HIE-2 and HIE-3, respectively. Axon guidance, Diseases of programmed cell death, and Detoxification of reactive oxygen species pathways were significantly enriched in mild HIE vs severe HIE. Of the differentially expressed proteins in various stages of HIE, we chose to validate four proteins- APP, AGT, FABP1, and FN1 via sandwich ELISA. Individual and cumulative ROC curves were plotted. AGT and FABP1 together showed high sensitivity, specificity, and accuracy as potential biomarkers for early diagnosis of HIE Conclusion: Establishing putative urinary biomarkers will facilitate clinicians to more accurately screen neonates for brain injury and monitor the disease progression. Prompt treatment of neonates may reduce mortality and neurodevelopmental impairment.

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Urinary angiotensinogen in pediatric urinary tract infection

Cited by 3 publications

References 15 publications

Low-frequency Electrical Stimulation Combined with Preventative Pelvic Floor Muscle Exercises and Knowledge-attitude-practice Model in Women with Urinary Retention after a Pelvic Surgery

Low-frequency Electrical Stimulation Combined with Preventative Pelvic Floor Muscle Exercises and Knowledge-attitude-practice Model in Women with Urinary Retention after a Pelvic Surgery

A comparative proteomic analysis for non‐invasive early prediction of hypoxic‐ischemic injury in asphyxiated neonates

A comparative proteomic analysis for non-invasive early prediction of hypoxic-ischemic injury in asphyxiated neonates

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