Urinary and hair concentrations of trace metals in pregnant women from Northeastern British Columbia, Canada: a pilot study

Caron-Beaudoin, Élyse; Bouchard, Michèle; Wendling, Gilles; Barroso, A. M. E.; Bouchard, Maryse F.; Ayotte, Pierre; Frohlich, Katherine L.; Verner, Marc-André

doi:10.1038/s41370-019-0144-3

Cited by 19 publications

(20 citation statements)

References 52 publications

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“…Some studies confirm the contamination of soils in oil and gas production areas with manganese [ 18 , 41 ], and some report no change in manganese concentration in soils of such regions. [ 17 , 42 ] Studies report an increase in the concentration of Mn in the hair of children living under conditions of industrial pollution [ 43 ] and the hair and urine of pregnant women from the regions of gas production by fracturing method [ 23 ]. The study by Moon et al is of great interest as being one of the oldest research for determining the concentration of chemical elements in the hair of residents from oil-producing regions [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…The hair of children living in areas of intensive mining activity showed higher concentrations of most of the metals and metalloids included in the study, including the essential trace element Zn [ 22 ]. There was an increase in the concentration of Mn in the urine and hair of pregnant women living in Northeastern British Columbia (Canada) in the area of intensive exploitation of natural gas by hydraulic fracturing [ 23 ]. Skalny et al report an increase in the essential elements Fe, Co, and I in the hair of petrochemical plant workers engaged in bitumen production [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Essential Trace Elements in Scalp Hair of Residents across the Caspian Oil and Gas Region of Kazakhstan

Umarova

Batyrova

Tlegenova

et al. 2022

Toxics

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Most of the country’s oil and gas fields are situated in West Kazakhstan, mainly on the Caspian Sea coast, causing significant damage to the local environment and contributing to an imbalance in the trace element composition of the human body. The study is aimed to evaluate the relationship between the concentration of essential trace elements in scalp hair of the western Kazakhstan adult population and the remoteness of their residence from oil and gas fields. The concentration of essential trace elements (Co, Cu, Fe, I, Mn, Se, Zn) in the hair of 850 individuals aged 18–60 years was determined by inductively coupled plasma mass spectrometry. In residents of settlements located at a distance of >110 km from oil and gas fields, the concentration of Cu and I in hair was significantly higher than in those closer to 110 km (p < 0.001). The content of Cu and I were associated with the distance to oil and gas fields (0.072 (95%CI: 0.050; 0.094)) and (0.121 (95%CI: 0.058; 0.185)), respectively. We detected a significant imbalance in the distribution of some essential trace elements in residents’ scalp hair from the Caspian region of western Kazakhstan, living near oil and gas fields. The concentrations of Cu and I were significantly interrelated with the distance to oil and gas fields. The level of copper in the hair of both inhabitants of the area most remote from oil and gas facilities and the entire population of western Kazakhstan as a whole remains significantly low. The data obtained provide evidence of the possible impact of pollutants generated by the oil and gas facilities on a shortage of essential trace elements and associated subsequent health risks.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Essential Trace Elements in Scalp Hair of Residents across the Caspian Oil and Gas Region of Kazakhstan

Umarova

Batyrova

Tlegenova

et al. 2022

Toxics

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“…Higher concentrations of volatile organic compounds (e.g., benzene, C2-C8 alkanes, aromatic hydrocarbons, methyl mercaptan, carbon disulfide, toluene) have also been measured in ambient air of several regions with unconventional natural gas exploitation compared with areas without hydraulic fracturing activity [5,[28][29][30][31]. We recently reported higher median concentrations of one benzene metabolite (trans, trans-muconic acid) and several trace metals (e.g., barium, aluminum, strontium, and manganese) in a pilot study of 29 pregnant women in Northeastern British Columbia compared to reference populations [11,12]. Exposure to trace metals, low levels of volatile organic compounds and/or poor indoor air quality has been associated with reduced birthweight [32][33][34][35][36][37][38] and increased risk of preterm birth [33,[39][40][41][42][43][44].…”

Section: Discussionmentioning

confidence: 99%

“…We recently investigated exposure to volatile organic compounds and trace metals in 29 pregnant women from Northeastern British Columbia. The concentrations of one benzene metabolite in urine (trans, trans-muconic acid) [11] and certain trace metals (e.g., barium, aluminum, strontium, and manganese) in urine and hair samples [12] were elevated compared to those from reference populations. For benzene metabolites, concentrations were compared with those measured in women from the general Canadian population who participated in the third cycle of the Canadian Health Measure Survey (CHMS).…”

Section: Introductionmentioning

confidence: 94%

Density and proximity to hydraulic fracturing wells and birth outcomes in Northeastern British Columbia, Canada

Caron-Beaudoin

Whitworth

Bosson-Rieutort

et al. 2020

J Expo Sci Environ Epidemiol

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Background Hydraulic fracturing, a method used in Northeastern British Columbia (Canada) to extract natural gas, can release contaminants with potential deleterious health effects on fetal development. To date, the association between hydraulic fracturing activity and birth outcomes has not been evaluated in this region. Objective To evaluate the association between the hydraulic fracturing well density/proximity and birth outcomes (birthweight, head circumference, preterm birth and small for gestational age (SGA)). Methods We used birth records from the Fort St John hospital between December 30, 2006 and December 29, 2016 (n = 6333 births). To estimate gestational exposure, we used inverse distance weighting (IDW) to calculate the density/proximity of hydraulic fracturing wells to pregnant women's postal code centroid. For each birth, we calculated three IDWs using 2.5, 5, and 10 km buffer zones around women's postal code centroid. We used linear and logistic regressions to evaluate associations between quartiles of postal code well density/proximity and birth outcomes, controlling for relevant covariates. Results No associations were found between postal code well density/proximity and head circumference or SGA. A negative association was found between postal code well density/proximity and birthweight for infants born to women in the 2nd quartile of the 10 km buffer (β [95% confidence interval (CI)]: −47.28 g [−84.30; −10.25]), and in the 2nd (β [95% CI]: −40.87 g [−78.01; −3.73]) and 3rd (β [95% CI]: −42.01 g [−79.15; −4.87]) quartiles of the 5 km buffer. Increased odds of preterm birth were observed among women in the 2nd quartile of the 2.5 km buffer (odds ratio (OR) [95% CI]: 1.60 [1.30; 2.43]). Conclusions This is the first epidemiological study in Northeastern British Columbia evaluating associations between hydraulic fracturing and health outcomes. Our results show inconsistent patterns of association between hydraulic fracturing, preterm birth and reduced birthweight, and effect estimates did not match expected dose-response relationships.

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“…Standard protocols for the analyses of low molecular weight metabolites in biofluids such as urine and plasma/serum are established for analytical techniques such as nuclear magnetic resonance spectroscopy [16], gas chromatography coupled with mass spectrometry (GC-MS) [17], and ultrahigh performance liquid chromatography mass spectrometry (UHPLC-MS) [18]. The application of metabonomics in exposure studies has been successfully applied using various specimens such as urine [19], saliva [20], hair [19], and blood [21] including plasma [22] and cord blood [23] samples. However, none have applied DBS for exposure studies despite previous comparisons of serum and plasma with DBS showed the analyses of DBS specimens were reproducible [24] and capable of detecting many metabolites that were similar to other blood matrices [25].…”

Section: Introductionmentioning

confidence: 99%

A feasibility study of metabolic phenotyping of dried blood spot specimens in rural Chinese women exposed to household air pollution

Loo

Carter

et al. 2020

J Expo Sci Environ Epidemiol

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Background Exposure-response studies and policy evaluations of household air pollution (HAP) are limited by current methods of exposure assessment which are expensive and burdensome to participants. Methods We collected 152 dried blood spot (DBS) specimens during the heating and non-heating seasons from 53 women who regularly used biomass-burning stoves for cooking and heating. Participants were enrolled in a longitudinal study in China. Untargeted metabolic phenotyping of DBS were generated using ultra-high performance liquid chromatography coupled with mass spectrometry to exemplify measurement precision and assessment for feasibility to detect exposure to HAP, evaluated by season (high pollution vs. low pollution) and measured personal exposure to fine particulate matter <2.5 μm diameters (PM 2.5) and black carbon (BC) in the 48-h prior to collecting the DBS specimen. Results Metabolites e.g., amino acids, acyl-carnitines, lyso-phosphorylcholines, sphinganine, and choline were detected in the DBS specimens. Our approach is capable of detecting the differences in personal exposure to HAP whilst showing high analytical reproducibility, coefficient of variance (CV) <15%, meeting the U.S. Food and Drug Administration criteria. Conclusions Our results provide a proof of principle that high-resolution metabolic phenotypic data can be generated using a simple DBS extraction method thus suitable for exposure studies in remote, low-resource settings where the collection of serum and plasma is logistically challenging or infeasible. The analytical run time (19 min/specimen) is similar to most global phenotyping methods and therefore suitable for large-scale application. Keywords Dried blood spot • Exposome • Metabonomics/metabolomics/metabolic phenotyping • Molecular epidemiological study • Biomass-related air pollution • PM 2.5

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Urinary and hair concentrations of trace metals in pregnant women from Northeastern British Columbia, Canada: a pilot study

Cited by 19 publications

References 52 publications

Essential Trace Elements in Scalp Hair of Residents across the Caspian Oil and Gas Region of Kazakhstan

Essential Trace Elements in Scalp Hair of Residents across the Caspian Oil and Gas Region of Kazakhstan

Density and proximity to hydraulic fracturing wells and birth outcomes in Northeastern British Columbia, Canada

A feasibility study of metabolic phenotyping of dried blood spot specimens in rural Chinese women exposed to household air pollution

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