Urinary and Fecal Excretion of Orally Administered Mg28.

Aikawa, Jerry K.; Rhoades, Eloise L.; Gordon, Gerald S.

doi:10.3181/00379727-98-23929

Cited by 30 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kinetic studies with radioactive 28 Mg have shown that parenterally administered Mg is excreted very slowly by the kidneys, but that the overall balance is maintained by a compensatory excretion of endogenous Mg (Aikawa, 1958). This exchange of the labeled dose with body Mg implicates that only a small part of the administered dose is excreted within 24 h. This amount might be too small to allow the detection of a difference between subjects with different muscle Mg concentrations.…”

Section: Discussionmentioning

confidence: 99%

Urinary excretion of an intravenous 26Mg dose as an indicator of marginal magnesium deficiency in adults

et al. 2005

View full text Add to dashboard Cite

Background: Measurement of magnesium (Mg) status is problematic because tissue Mg deficiency can be present without low serum Mg concentrations. Objective: To evaluate a modified version of the Mg retention test using stable isotopes for the assessment of Mg status in general, and the detection of marginal Mg deficiency in particular. Design: A modified version of the Mg retention test using a small dose of 26 Mg was evaluated for assessment of Mg status in 22 healthy subjects. Muscle Mg concentration was used as reference for Mg status. A muscle biopsy was taken from the lateral portion of the quadriceps muscle from each subject. After 2 to 4 weeks, 11 mg of 26 Mg (as MgCl 2 in 14 ml water) were injected i.v. over a period of 10 min and all urine was collected for the following 24 h. Excretion of the isotopic label was expressed as percentage of the administered dose excreted in urine within 24 h. Results: Mean7s.d. Mg concentration in muscle was 3.8570.17 mmol/100 g fat-free dried solids. Mean7s.d. excretion of the injected dose within 24 h was 7.972.1%. No correlation was found between muscle Mg concentration and excretion of the isotopic label (r 2 ¼ 0.061, P ¼ 0.27). Conclusions: In this study, urinary excretion of an intravenous Mg tracer was not influenced by muscle Mg concentration and its usefulness for the detection of marginal Mg deficiency could therefore not be demonstrated. Sponsorship:

show abstract

Section: Discussionmentioning

confidence: 99%

Urinary excretion of an intravenous 26Mg dose as an indicator of marginal magnesium deficiency in adults

et al. 2005

View full text Add to dashboard Cite

show abstract

“…It has been rep orted that , in bo th hum ans an d experimen tal anima ls , at least 65% of an intravenou s dose of magnesium is recovered in the urine durin g the first 24 h following the infu sion (18)(19)(20)(21)(22). In adults, 80% of an intr amuscular do se of magnesium was ex crete d in the urine wit hin 24 h, with most of the load eliminat ed during the first 4 h (1,4).…”

Section: Discussionmentioning

confidence: 99%

Magnesium Metabolism Studies in Children with Chronic Inflammatory Disease of the Bowel

LaSala,

Lifshitz,

Silverberg

et al. 1985

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

Magnesium metabolism was studied in seven patients with severe chronic inflammatory disease of the bowel (CIDB), and in 20 children without intestinal pathology. Four of the CIDB patients had ulcerative colitis and three had granulomatous disease of the bowel. All had diarrhea as well as other gastrointestinal complaints for 1 to 6 years prior to the study. All were being treated with sulfasalazine and were also receiving corticosteroids intermittently. All but one had had intestinal surgery. Basal plasma and urine were obtained in all patients and, if surgery was performed, a piece of muscle was excised. The CIDB patients received an intravenous magnesium infusion of 2 mEq/kg/day for 4 days, 2 days postsurgery. Electrocardiograms were recorded throughout the study. The mean basal plasma magnesium levels were reduced in CIDB patients as compared with controls. Mild hypomagnesemia was observed in six of seven CIDB patients. The mean basal urine excretion of magnesium was also reduced in CIDB patients, but the muscle concentrations of this element were similar to controls. Basal hypomagnesuria was present in only two of the three patients with granulomatous disease and in one patient with ulcerative colitis. The three patients with granulomatous disease excreted minimal amounts of magnesium in the urine during intravenous administration of this ion. A positive magnesium balance persisted throughout the 4‐day period of infusion. In contrast, only two of the four patients with ulcerative colitis had magnesium retention during the first day of intravenous administration, and all four had negative magnesium balances thereafter. The data suggest that hypomagnesemia in CIDB patients may occur with or without magnesium deficiency. However, the excretion of magnesium in urine after a parenteral magnesium load was the best index of magnesium deficiency. In three CIDB patients, with involvement of small bowel, magnesium depletion was found.

show abstract

“…Naturally, the differ ent absorption conditions for calcium in the intestine also play a decisive role for the excretion in the urine. Studies by Aikawa et al (1958) with labelled magnesium showed the poor intestinal absorption of magnesium. It has been possible to show, in long-term studies, that the urinary excretion of magnesium always increases in the second half of the long-term experiment.…”

Section: Discussionmentioning

confidence: 99%