Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine and Biopyrrins Levels among Construction Workers with Asbestos Exposure History.

Abstract

It has been suggested that oxidative stress is associated with the cancers caused by asbestos. Since construction workers are sometimes exposed to low levels of asbestos, we investigated whether oxidative stress was elevated in construction workers who had been exposed to low levels of asbestos. The subjects were 48 Japanese construction workers. The defined asbestos-exposed group consisted of subjects who had the history of suspected exposure to asbestos and were diagnosed to have irregular opacities or pleural plaques. We measured the amount of 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodG) and biopyyrins in the urine of the subjects. The results showed that 8-oxodG and biopyyrins levels in the defined asbestos-exposed group were higher, although they were not statistically significant, than those in the control group. In addition, the urinary 8-oxodG levels tended to correlate positively with the duration of suspected exposure to asbestos. These results suggest that even lowlevel asbestos exposure may induce oxidative stress and that the resulting's the oxidative stress might be related to lung cancer in construction workers.

Studies on serum nitric oxide levels in subjects with high bilirubin value in comparison of normal healthy control subjects

“…It has been demonstrated a close correlation between these markers (called biopyrrins) and many other pathologic conditions including ischemic heart disease (36,37) congestive heart failure (38), atopic dermatitis (39), and surgical (40,41) or even psychological stress (42). The same relationship was also found for asbestos-induced oxidative stress (43). Close associations between biopyrrin levels in cerebrospinal fluid and childhood meningitis (39) and Alzheimer's disease (44) were also demonstrated, suggesting that bilirubin consumption during oxidative stress may belong to the major pathways, preventing deleterious effects of oxidative stress.…”

Redox State, Oxidative Stress, and Molecular Mechanisms of Protective and Toxic Effects of Bilirubin on Cells

“…These include: acute psychological stress [77], surgical stress [78,79], sepsis [80], coronary heart disease [81,82], congestive heart failure [83], atopic dermatitis [84], meningitis [84], schizophrenia and depressions [85], Alzheimer´s disease [86], and chronic exposure to asbestos [87]. Interestingly, subjects with Gilbert syndrome, who have low levels of oxidative stress, excrete low levels of urinary biopyrrins [88].…”

Effects of Drinking a Water Product with Anti-Oxidant Activities In Vitro on the Blood Levels of Biomarker Substances for the Oxidative Stress

“…Some oxidative stress markers should be monitored not only in the blood but also in the urine, since the oxidative damage is reflected also by increased excretions of BP and oxidation products of guanosine. 11,12) Effects of drinking a greater quantity of water than usual should also be quantitatively studied.…”