Urinary 8-hydroxydeoxyguanosine as a marker of oxidative stress induced genetic toxicity in oral cancer patients

Murugaiyan, Sathish Babu; Ramesh, R.; Nakkeeran, M; Rangdhol, Vishwanath; Srinivasan, Abu Raghavan; Niranjan, G

doi:10.4103/0970-9290.162880

Cited by 9 publications

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“…Oxidative DNA damage induced by reactive oxygen species (ROS) plays a pivotal role in the nosogenesis of respiratory disease such as lung cancer and asthma [1, 2]. ROS, resulting from chemical compounds or the action of exogenous physical factors such as ultraviolet A, or the metabolism of cells, can induce a great many DNA damage, including base modification and DNA strand breaks [3], were generally believed to be involved in the carcinogenic mechanism [4, 5]. Previous studies have shown that 8-hydroxy- 2′- deoxyguanosine (8-OHdG) is a widely accepted biomarker for assessing the extent of oxidative damage to DNA [6].…”

Section: Introductionmentioning

confidence: 99%

CYP1A1 methylation mediates the effect of smoking and occupational polycyclic aromatic hydrocarbons co-exposure on oxidative DNA damage among Chinese coke-oven workers

Li¹,

Li²,

Zhang³

et al. 2019

Environ Health

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Background Multiple factors, including co-exposure between lifestyle and environmental risks, are important in susceptibility to oxidative DNA damage. However, the underlying mechanism is not fully understood. This study was undertaken to evaluate whether Cytochrome P4501A1 ( CYP1A1 ) methylation can mediate the co-exposure effect between smoking and occupational polycyclic aromatic hydrocarbons (PAH) in development of oxidative DNA damage. Methods We explored the associations between smoking and occupational PAH co-exposure effect, CYP1A1 methylation and oxidative DNA damage among 500 workers from a coke-oven plant in China. Urine biomarkers of PAH exposure (1-hydroxypyrene, 1-OHP; 2-hydroxynaphthalene, 2-NAP; 2-hydroxyfluorene, 2-FLU; and 9-hydroxyphenanthren, 9-PHE) and a marker of oxidative DNA damage (8-hydroxy- 2′- deoxyguanosine, 8-OHdG) were measured by high performance liquid chromatography. CYP1A1 methylation was measured by pyrosequencing. Finally, mediation analysis was performed to investigate whether CYP1A1 methylation mediated smoking and occupational PAH co-exposure effect on oxidative DNA damage. Results We observed significant associations of smoking and 1-OHP co-exposure with CYP1A1 hypomethylation (OR: 1.87, 95% CI: 1.01–3.47) and high 8-OHdG (OR: 2.13, 95% CI: 1.14–3.97). There was a significant relationship between CYP1A1 hypomethylation and high 8-OHdG (1st vs. 3rd tertile = 1.58, 95% CI: 1.01–2.47, P for trend = 0.046). In addition, mediation analysis suggested CYP1A1 hypomethylation could explain 13.6% of effect of high 8-OHdG related to smoking and 1-OHP co-exposure. Conclusions Our findings suggested that the co-exposure effect of smoking and occupational PAH could increase the risk of oxidative DNA damage by a mechanism partly involving CYP1A1 hypomethylation. Electronic supplementary material The online version of this article (10.1186/s12940-019-0508-0) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

CYP1A1 methylation mediates the effect of smoking and occupational polycyclic aromatic hydrocarbons co-exposure on oxidative DNA damage among Chinese coke-oven workers

Li¹,

Li²,

Zhang³

et al. 2019

Environ Health

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Analytical and Omics Approaches in the Identification of Oxidative Stress-Induced Cancer Biomarkers

Gajula¹,

Bale²,

Satheeshkumar³

2021

Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

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Analytical and Omics Approaches in the Identification of Oxidative Stress-Induced Cancer Biomarkers

Gajula

Bale

Satheeshkumar

2022

Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

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Urinary 8-hydroxydeoxyguanosine as a marker of oxidative stress induced genetic toxicity in oral cancer patients

Abstract: Urinary 8-OHdG can be a useful diagnostic marker of oxidative DNA damage in oral cancer subjects.

Cited by 9 publications

References 0 publications

CYP1A1 methylation mediates the effect of smoking and occupational polycyclic aromatic hydrocarbons co-exposure on oxidative DNA damage among Chinese coke-oven workers

CYP1A1 methylation mediates the effect of smoking and occupational polycyclic aromatic hydrocarbons co-exposure on oxidative DNA damage among Chinese coke-oven workers

Analytical and Omics Approaches in the Identification of Oxidative Stress-Induced Cancer Biomarkers

Analytical and Omics Approaches in the Identification of Oxidative Stress-Induced Cancer Biomarkers

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