Urinary 8-Hydroxy-2′-Deoxyguanosine as a Myocardial Oxidative Stress Marker Is Associated With Ventricular Tachycardia in Patients With Active Cardiac Sarcoidosis

Ishiguchi, Hironori; Kobayashi, Shigeki; Myoren, Takeki; Kohno, Michiaki; Nanno, Takuma; Murakami, Wakako; Oda, Shinobu; Oishi, K; Okuda, Shinichi; Okada, Munemasa; Suga, Kazuyoshi; Yano, Masafumi

doi:10.1161/circimaging.117.006764

Cited by 13 publications

(25 citation statements)

References 26 publications

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“…An increase in PARP1 activity in the failing heart was linked to coronary artery disease in diabetes patients ( 33 , 34 ). Likewise, secreted 8-OHdG levels were increased in cardiomyopathy, HF, and cardiac sarcoidosis patients ( 35 – 37 ). We detected significantly higher levels of PARP1 and 8-OHdG in serum/plasma and the PARP1 active form in PBMCs of CD subjects.…”

Section: Discussionmentioning

confidence: 96%

Prognostic Performance of Peripheral Blood Biomarkers in Identifying Seropositive Individuals at Risk of Developing Clinically Symptomatic Chagas Cardiomyopathy

et al. 2021

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Section: Discussionmentioning

confidence: 96%

Prognostic Performance of Peripheral Blood Biomarkers in Identifying Seropositive Individuals at Risk of Developing Clinically Symptomatic Chagas Cardiomyopathy

et al. 2021

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“…These include TNFα, soluble interleukin-2 receptor, angiotensin converting enzyme, cardiac troponins, BNP, miR-126 and miR-223, and the oxidative stress marker 8-hydroxy-2'deoxyguanosine (U-8-OHdG). [20][21][22][23][24][25][26] However, there remains a paucity of biomarkers specific for active cardiac involvement, and the development of additional CS-specific clinical markers through larger, more robust studies could facilitate more targeted immunosuppressive therapy for patients at elevated risk of adverse outcomes within the sarcoidosis patient population.…”

Section: Fdg Imaging and Potential Integration Of Biomarker Profilingmentioning

confidence: 99%

Cytokine Signaling and Matrix Remodeling Pathways Associated with Cardiac Sarcoidosis Disease Activity Defined Using FDG PET Imaging

et al. 2021

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While cardiac imaging has improved the diagnosis and risk assessment for cardiac sarcoidosis (CS), treatment regimens have consisted of generalized heart failure therapies and non-specific anti-inflammatory regimens. The overall goal of this study was to perform high-sensitivity plasma profiling of specific inflammatory pathways in patients with sarcoidosis and with CS.Specific inflammatory/proteolytic cascades were upregulated in sarcoidosis patients, and certain profiles emerged for CS patients.Plasma samples were collected from patients with biopsy-confirmed sarcoidosis undergoing F-18 fluorodeoxyglucose positron emission tomography (n = 47) and compared to those of referent control subjects (n = 6). Using a high-sensitivity, automated multiplex array, cytokines, soluble cytokine receptor profiles (an index of cytokine activation), as well as matrix metalloproteinase (MMP), and endogenous MMP inhibitors (TIMPs) were examined.The plasma tumor necrosis factor (TNF) and soluble TNF receptors sCD30 and sTNFRI were increased using sarcoidosis, and sTNFRII increased in CS patients (n = 18). The soluble interleukin sIL-2R and vascular endothelial growth factor receptors (sVEGFR2 and sVEGFR3) increased to the greatest degree in CS patients. When computed as a function of referent control values, the majority of soluble cytokine receptors increased in both sarcoidosis and CS groups. Plasma MMP-9 levels increased in sarcoidosis but not in the CS subset. Plasma TIMP levels declined in both groups.The findings from this study were the identification of increased activation of a cluster of soluble cytokine receptors, which augment not only inflammatory cell maturation but also transmigration in patients with sarcoidosis and patients with cardiac involvement.

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“…[19][20][21] The quantitative analysis of 18 F-FDG uptake in the lesion was based on the maximum standardized uptake value (SUVmax) per focus, as described previously. [19][20][21] The intensity of myocardial FDG uptake was quantified by measuring the SUV in all 17 segments, in accordance with the Scientific Statement from American Heart Association. Analysis of myocardial FDG uptake was performed by recognizing the endomyocardial and epicardial borders and by subdividing the LV in each segment.…”

Section: Evaluation Of Va and LV Wall Thinning In Patients With Activmentioning

confidence: 99%

“…Other Neurohumoral/Inflammatory Factors U-8-OHdG concentrations, a marker of oxidative stress, were measured using an enzyme-linked immunosorbent assay kit (Japan Institute for the Control of Aging, Fukuroi, Japan) with anti-8-OHdG antibody (N45.1), as described previously. [19][20][21][22] Other neurohumoral and inflammatory factors were measured as described previously. [19][20][21][22] Steroid Therapy for Active CS Corticosteroid treatment (prednisolone) was initiated according to existing Japanese protocols as follows: 30 mg/day for 4 weeks with gradual tapering of the dose to 5-10 mg every other day over 6 months to establish the minimal heart, which comprised viable myocardium as evaluated by other modalities.…”

Section: Measurement Of Urinary 8-hydroxy-2'-deoxyguanosine (U-8-ohdgmentioning

confidence: 99%

Detection of Active Inflammation Status Around Ventricular Aneurysms in Patients With Cardiac Sarcoidosis

Nanno

Kobayashi

Yoshitomi

et al. 2019

Circ J

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Background: Little is known about the pattern of isotope accumulation in the heart on 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography in patients with cardiac sarcoidosis (CS) complicated by ventricular aneurysm (VA). Methods and Results: We prospectively enrolled 82 consecutive patients with CS; 54 patients with active CS (presence of abnormal 18 F-FDG accumulation in the heart) were subdivided into VA (n=17) and non-VA groups (n=37). Strong 18 F-FDG accumulation surrounding the VA and its disappearance in the VA center was observed in all patients with VA, probably because of scar formation at the VA. Peak standardized uptake value was higher around the VA than in the VA center (5.1±2.1 vs. 2.2±0.6, P=0.0003) and the VA center had no 18 F-FDG accumulation (VA center: 2.2±0.6 vs. control area: 2.1±0.6, P=0.37). On the other hand, in non-VA patients with LV wall thinning (n=28), 18 F-FDG accumulation was significantly high, even in the area of LV wall thinning (LV wall thinning area: 3.1±0.8 vs. control area: 2.0±0.6, P=0.00002). Conclusions: A pattern of strong 18 F-FDG accumulation surrounding the VA and its disappearance in the VA center might be characteristic in patients with CS complicated by VA. Careful attention to FDG uptake would further elucidate CS pathophysiology and aid in the early treatment of VA.

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Urinary 8-Hydroxy-2′-Deoxyguanosine as a Myocardial Oxidative Stress Marker Is Associated With Ventricular Tachycardia in Patients With Active Cardiac Sarcoidosis

Abstract: U-8-OHdG levels are associated with VT in patients with active CS diagnosed by F-flurodeoxyglucose positron-emission tomography, providing additive and relevant information about the arrhythmia substrate.

Cited by 13 publications

References 26 publications

Prognostic Performance of Peripheral Blood Biomarkers in Identifying Seropositive Individuals at Risk of Developing Clinically Symptomatic Chagas Cardiomyopathy

Prognostic Performance of Peripheral Blood Biomarkers in Identifying Seropositive Individuals at Risk of Developing Clinically Symptomatic Chagas Cardiomyopathy

Cytokine Signaling and Matrix Remodeling Pathways Associated with Cardiac Sarcoidosis Disease Activity Defined Using FDG PET Imaging

Detection of Active Inflammation Status Around Ventricular Aneurysms in Patients With Cardiac Sarcoidosis

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