Urinary 6β-hydroxycortisol excretion in Hong Kong Chinese patients with hepatocellular carcinoma and other chronic liver diseases

Abstract

Our results show an increase in mean CYP3A4 enzyme activity, reflected as an increase in the 6 beta OHF/F ratio, in Hong Kong Chinese with nonresectable HCC compared with those with resectable HCC and other liver diseases. Although the role of increased CYP3A4 activity in the aetiology of HCC is not known, our specificity and sensitivity estimates suggest that a high 6 beta OHF/F ratio indicates probable inoperability. However, a normal level is a poor predictor of resectability.

Study of the Urinary Ratio of 6 β-Hydroxycortisol/Cortisol as a Biomarker of CYP3A4 Activity in Egyptian Patients with Chronic Liver Diseases

“…The present study showed gender-related difference in the activity of CYP3A4 among Egyptians (Table 2). Among the control group, females had lower values of the urinary ratio of 6β-OHC/C in comparison with males; a result that coincides with previously reported data among Egyptians (ELDesoky et al 2005) and other populations (Lee, 1995;NG et al 1996). However, other studies demonstrated higher values of the urinary ratio in females compared with males (Inagaki et al 2002).…”

“…Although the ratio does not always correlate with the disposition of CYP3A substrate drugs, including the typical phenotyping probe drugs such as [ 14 C]-erythromycin and midazolam (Hunt et al 1992;Watkins et al 1992;Kinirons et al 1993Kinirons et al , 1999, but recent studies have described successful utilization of the urinary ratio 6 β-OHC/C as a measure of CYP3A induction (Saima et al 2002;Uejima et al 2002;ELDesoky et al 2005;Yeo et al 2006). Furthermore, the urinary ratio has also been studied in some disease conditions to elucidate a possible correlation of CYP3A activity with disease states such as hepatic disease, thyroid disorders and cancer (NG et al 1996;Zheng et al 2001;Szucs et al 2003;Kishino et al 2004;Hoshiro et al 2006).…”