Urinary 6‐sulphatoxy Melatonin Excretion During the Human Menstrual Cycle

Fellenberg, A. J.; Phillipou, G.; Seamark, R.F.

doi:10.1111/j.1365-2265.1982.tb02635.x

Cited by 26 publications

(6 citation statements)

References 10 publications

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“…However, these researchers reported an increase in daily melatonin secretion between the follicular and luteal menstrual phases, a finding that was not confirmed in our study. Our conclusions are, however, in agreement with the results of another recent study (25) ing the menstrual cycle. We also found that the daily pattern of PRL secretion changed little through the menstrual cycle.…”

Section: Discussionsupporting

confidence: 90%

The Circadian Rhythm of Plasma Melatonin During the Normal Menstrual Cycle and in Amenorrheic Women*

Brzezinski¹,

Lynch²,

Seibel³

et al. 1988

The Journal of Clinical Endocrinology & Metabolism

167

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Plasma melatonin, PRL, and LH levels were measured in samples collected every 2 h for 24 h from 14 normally cycling women during the early follicular, periovulatory, and luteal phases of their menstrual cycles. Plasma melatonin levels also were measured in samples collected at the same interval from 7 patients with hypothalamic amenorrhea. A distinct daily rhythm in plasma melatonin was evident in all subjects, with peaks occurring around 0300 h. Each woman's rhythm was remarkably consistent throughout the menstrual cycle (in terms of the phase, amplitude, and total melatonin secreted). Plasma PRL levels also exhibited daily rhythms which did not change during the menstrual cycle; the nocturnal peak plasma PRL level tended to occur 1-2 h after that for melatonin. Among the amenorrheic women, both daytime and nighttime melatonin levels were significantly higher (P less than 0.005) than in the normal women. Their plasma PRL levels were similar to those in the normal women. We conclude that, as for PRL, the circadian rhythm of melatonin secretion does not change significantly during the normal menstrual cycle. The elevated plasma melatonin levels in women with hypothalamic amenorrhea suggest that the hormone may be involved in the neuroendocrine pathology underlying this disorder.

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Section: Discussionsupporting

confidence: 90%

The Circadian Rhythm of Plasma Melatonin During the Normal Menstrual Cycle and in Amenorrheic Women*

Brzezinski¹,

Lynch²,

Seibel³

et al. 1988

The Journal of Clinical Endocrinology & Metabolism

167

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“…With the development of a RIA for 6-sulphatoxymelatonin (1), it has been possible to monitor the excretion of 6-sulphatoxymelatonin into the urine of humans (10), rats (17), Djungarian hamsters (21), minks (26), and pigs (19). In all cases, the excretion rate of 6-sulphatoxymelatonin is rhythmic and can be used as an index of pineal gland rhythmicity (10). There is a clear advantage in such a procedure due to the noninvasive nature and simplicity of urine collection that reduces the number of animals needed for experiments.…”

Section: Discussionmentioning

confidence: 99%

Melatonin in mice: rhythms, response to light, adrenergic stimulation, and metabolism

Kennaway

Voultsios

Varcoe

et al. 2002

American Journal of Physiology-Regulatory, Integrative and Comp

111

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There has been relatively little research conducted on pineal melatonin production in laboratory mice, in part, due to the lack of appropriate assays. We studied the pineal and plasma rhythm, response to light, adrenergic stimulation, and metabolism of melatonin in CBA mice. With the use of a sensitive and specific melatonin RIA, melatonin was detected in the pineal glands at all times of the day >21 fmol/gland in CBA mice but not in C57Bl mice. Both plasma and pineal melatonin levels peaked 2 h before dawn in a 12:12-h light-dark photoperiod (162 ± 31 pM and 1,804 ± 514 fmol/gland, respectively). A brief light pulse (200 lx/15 min), 2 h before lights on, suppressed both plasma and pineal melatonin to near basal levels within 30 min. Exposure to light pulses 4 h after lights off or 2 h before lights on resulted in delays and advances, respectively, in the early morning decline of plasma and pineal melatonin on the next cycle. Administration of the β-adrenergic agonist isoproterenol (20 mg/kg) 2 and 4 h after lights on in the morning resulted in a fivefold increase in plasma and pineal melatonin 2.5 to 3 h after the first injection. In the mouse, unlike the rat, melatonin was shown to be metabolized almost exclusively to 6-glucuronylmelatonin rather than 6-sulphatoxymelatonin. These studies have shown that the appropriate methodological tools are now available for studying melatonin rhythms in mice.

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“…The daily urinary excretion of 6-sulfatoxymeiatonin did not vary in 2 women whose menstrual cycles were characterized by daily uri nary pregnanediol and estrone [12]. The concentration of 6-hydroxymelatonin, a major melatonin metabolite, in daily 24-hour urine samples also showed no consistent relationship with menstrual phase in 6 women whose menstrual cyclicity was documented by serum estradiol and progesterone levels ob tained at 2-to 3-day intervals [ 13].…”

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confidence: 92%

Circadian Pattern of Plasma Melatonin Concentrations during Four Phases of the Human Menstrual Cycle

Berga

Yen²

1990

Neuroendocrinology

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The role of melatonin in human reproductive physiology remains obscure. Previous investigations of the nocturnal melatonin secretory pattern during the human menstrual cycle have yielded conflicting results and have been limited by incomplete characterization of the pertinent features of the circadian pattern such as magnitude, duration, or circadian position of the nocturnal increase, by incomplete assessments of ovarian secretion and menstrual cycle phase, or by both. In the present study, the circadian melatonin profile was characterized by obtaining plasma samples at hourly intervals from 10.00 to 17.00 h and at half-hourly intervals from 17.00 to 10.00 h in 10 women during four prospectively estimated menstrual phases: early follicular, late follicular, midluteal, and late luteal. Menstrual phases and ovarian function were confirmed by obtaining daily serum samples for LH, FSH, estradiol, and progesterone during the entire menstrual cycle. Eight women had ovulatory cycles with luteal lengths of greater than 11 days and with determinations of the circadian melatonin pattern during each menstrual phase. Despite gonadal steroid excursions characteristic of ovulatory cycles, consistent variations in plasma melatonin patterns by menstrual phase were not found. Daytime levels were at or below 43 pmol/l in all women and all but 2 women displayed prominent nocturnal elevations. While changes in the circadian pattern of melatonin secretion immediately preceding the LH surge cannot be excluded, the lack of consistent variation by menstrual cycle phase and the absence of clear circadian variation found in 2 women suggests that the secretory profile of melatonin is unaltered by fluctuations in gonadal steroids and that melatonin secretion may not be necessary for menstrual cyclicity to occur.

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Urinary 6‐sulphatoxy Melatonin Excretion During the Human Menstrual Cycle

Cited by 26 publications

References 10 publications

The Circadian Rhythm of Plasma Melatonin During the Normal Menstrual Cycle and in Amenorrheic Women*

The Circadian Rhythm of Plasma Melatonin During the Normal Menstrual Cycle and in Amenorrheic Women*

Melatonin in mice: rhythms, response to light, adrenergic stimulation, and metabolism

Circadian Pattern of Plasma Melatonin Concentrations during Four Phases of the Human Menstrual Cycle

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