Urinary 17-hydroxycorticosteroid levels in parents of children with neoplastic disease

Friedman, Stanford B.; Mason, John W.; Hamburg, David A.

doi:10.1097/00006199-196401320-00048

Cited by 29 publications

(28 citation statements)

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“…An alternative explanation could be that the anxious patient experiences a welter of stressful stimuli in life and is in a continuous state of almost full habituation or inhibition. The biochemical study of Friedman, Mason, and Hamburg (1963) shows a rather similar result in a study of corticosteroid excretion in the parents of children with neoplastic disease. Marked increases in 17hydroxycorticosteroid excretion are commonly observed in subjects under acute psychological stresses.…”

Section: Discussionsupporting

confidence: 61%

The habituation of forearm muscle blood flow in phobic subjects.

Brierley¹

1969

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Discussionsupporting

confidence: 61%

The habituation of forearm muscle blood flow in phobic subjects.

Brierley¹

1969

Journal of Neurology, Neurosurgery & Psychiatry

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“…[56-59] In children, hypocortisolism has been reported in at risk populations of children,[37] including children with chronic stress,[43, 44, 60] children reared in institutions,[61] or in foster care, [62, 63] boys with attention problems, [64] clinically depressed maltreated school aged children,[65, 66] boys of low income depressed mothers,[67] post-traumatic stress disorder,[68] boys with antisocial behavior [69-75] and autism. [76] Blunting specifically has been found in children with psychosocial dwarfism,[77] atopic dermatitis,[35] Oppositional Defiant Disorder (ODD),[78] juvenile delinquents with ODD and Conduct Disorder (CD),[79] early onset or adolescent onset CD,[80] sexually abused girls,[81] and maltreated children.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Cocaine Exposure Related to Cortisol Stress Reactivity in 11-Year-Old Children

Lester

LaGasse

Shankaran

et al. 2010

The Journal of Pediatrics

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Objective Determine the association between prenatal cocaine exposure and postnatal environmental adversity on salivary cortisol stress reactivity in school aged children. Study design Subjects included 743 11 year old children (n=320 cocaine exposed; 423 comparison) followed since birth in a longitudinal prospective multisite study. Saliva samples were collected to measure cortisol at baseline and after a standardized procedure to induce psychological stress. Children were divided into those who showed an increase in cortisol from baseline to post stress and those who showed a decrease or blunted cortisol response. Covariates measured included site, birthweight, maternal pre and postnatal use of alcohol, tobacco or marijuana, social class, changes in caretakers, maternal depression and psychological symptoms, domestic and community violence, child abuse and quality of the home. Results With adjustment for confounding variables, cortisol reactivity to stress was more likely to be blunted in children with prenatal cocaine exposure. Cocaine exposed children exposed to domestic violence showed the strongest effects. Conclusion The combination of prenatal cocaine exposure and an adverse postnatal environment could down regulate the hypothalamic-pituitary-adrenal axis (HPA) resulting in the blunted cortisol response to stress possibly increasing risk for later psychopathology and adult disease.

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“…Analyses of these 72-hour pools for Daly Field Observations.-Three en¬ listed men, trained as observers, remained with the platoon each day during field exercises and in the evening in the barracks. Daily report forms were completed for each recruit summariz¬ ing the following information: (1) ac¬ tivities differing from the platoon's, (2) unusual interaction with the training cadre, (3) important personal events re¬ lating to family or friends, and (4) estimates of attitude and mood.…”

Section: Methodsmentioning

confidence: 99%

Psychological State and Body Size as Determinants of 17-OHCS Excretion

Rose¹,

Poe²,

Mason³

1968

Arch Intern Med

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The 17-hydroxycorticosteroid (17-OHCS) excretion was measured in recruits during the first month of basic combat training. Twenty-seven men were interviewed and observed daily, after which predictions were made of the degree of arousal individuals experienced during training.These assessments of psychological state and estimates of body size correlated significantly with 17-OHCS excretion. Combined use of both variables provided better prediction than either alone. It has been found that most individ¬ uals have a characteristic and usually narrow range of 17-hydroxy¬ corticosteroid (17-OHCS) excretion over long periods of time.1"·' Two known principal determinants of chronic mean basal excretion are body size4"8 and psychological state.01"' There are numerous studies that report a positive relationship be¬ tween estimates of body size such as body weight4~~a nd body surface area 4-81".17 and indices of adrenocortical function, including the urinary excretion of various corticoids,""8·18 response to administered adrenocorticotrophic hormone (ACTrl),10·17 and estimates of cortisol secre¬ tion.10·10 Recent studies of the re-lationship between adrenocortical activity and psychological state have indicated that certain stable per¬ sonality characteristics can be used to predict the level of 17-OHCS excretion in individuals exposed to chronically distressing situa¬ tions.13·14·20The combined influence of body size and psychological state has not been studied systematically in the same population. Hence it has been difficult to assess the relative impor¬ tance of these factors or determine any possible interaction between them. The purpose of the present study was to evaluate the relation¬ ship between body size and 17-OHCS excretion in a population of young men who were also studied psycho¬ logically and whose responses to the environment were predicted and cor¬ related with actual corticoid excre¬ tion. MethodsSubjects.-The subjects consisted of 50 white young adult men, ages 17 to 26 (mean age of 21), who had just been recruited into the Army at Ft. Dix, NJ. All but one were single. The entire group came from New York and New Jersey, approximately one half from New York City, one quarter from small urban communities, and the rest from rural backgrounds. All but two were high school graduates. Two thirds had attended some college and 12 were col¬ lege graduates. Approximately one half were Catholic, one quarter were Prot¬ estant, and one quarter were Jewish.The group comprised a complete pla¬ toon, one of five in a basic training company, and proceeded in training similar to the other platoons.Sample Collection.-A continuous 72hour urine collection was made once a

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Urinary 17-hydroxycorticosteroid levels in parents of children with neoplastic disease

Cited by 29 publications

References 0 publications

The habituation of forearm muscle blood flow in phobic subjects.

The habituation of forearm muscle blood flow in phobic subjects.

Prenatal Cocaine Exposure Related to Cortisol Stress Reactivity in 11-Year-Old Children

Psychological State and Body Size as Determinants of 17-OHCS Excretion

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