Urinary 1-hydroxypyrene in occupationally-exposed and non-exposed individuals in Silesia, Poland

Abstract

Introduction. The aim of presented study was comparison of urinary 1-hydroxypyrene concentration among coke plant workers (before and after working week) and among non-exposed individuals from the same area, taking smoking status into consideration. Materials and method. 647 coke plant workers and 206 individuals living in the same area were analysed with respect to urinary 1-OHP concentration and smoking status. Urinary samples were measured using high performance liquid chromatography (HPLC) with fluorescent detection. Concentrations were normalized with respect to creatinine concentration. For workers, two samples were collected before and after working week. Multiple regression was performed to distinguish and quantify the influence of cigarette smoking and occupational PAH exposition on the urinary 1-OHP levels. Results. Average urinary 1-OHP concentration of samples collected before the working week was: 1.07 μg/g; after the working week: 2.36 μg/g and for control: 0.74 μg/g. The samples collected at the beginning of the working week were not suitable for assessment of the workers' background (non-occupational) exposition. Smoking cigarettes induced a rise in urinary 1-OHP level by 16%, on average (CI: 5% -28%), and working for a whole working week at the coke plant made urinary 1-OHP levels, on average, 3.21 times higher (CI: 2.91 -3.54). Conclusions. Working at the coke plant increases significantly urinary 1-OHP concentration in comparison to nonoccupationally exposed individuals, both for samples collected before and after the working week. Smoking remains a significant source of PAHs exposition, despite the fact that occupational exposure is greater. Health promotion programmes should address both the occupational health risks reduction and smoking prevention.

Risk of Pulmonary-Reproductive Dysfunctions, Inflammation and Oxidative DNA Damage in Exposure to Polycyclic Aromatic Hydrocarbon in Cigarette Smokers

“…Besides, smoking yields of PAH compounds have been shown to vary considerably based on the type of cigarette, genetic variability and individual differences in PAH metabolizing enzymes and smoking pattern ( 26 ). However, CS has been shown to induce a 16% increase in urinary 1-HOP excretion and active smokers have been reported to have higher urine levels of 1-HOP than non-smokers ( 27 , 28 ).…”

The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review

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Non-carcinogenic and cumulative risk assessment of exposure of kitchen workers in restaurants and local residents in the vicinity of polycyclic aromatic hydrocarbons

“…The incomplete combustion of organic waste results in a unique type of environmental pollutant known as PAHs 1 , 2 . These contaminants stay in the ecosystem and build up in the food supply 3 .…”