Urinary 1-hydroxypyrene and 2-naphthol concentrations in male Koreans

Kim, H.; Cho, S. H.; Kang, Jeong Woo; Kim, Y. D.; Nan, Hongmei; Lee, C. H.; Lee, H.; Kawamoto, Toshihiro

doi:10.1007/s004200000193

Cited by 99 publications

(43 citation statements)

References 7 publications

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“…1). These data are in agreement with previous reports (Kim et al 2001;Serdar et al 2004). These results also show that JP-8 exposure resulted in signiWcantly elevated urinary naphthol excretion, and cigarette smoking was a slightly confounding factor for these results.…”

Section: Discussionsupporting

confidence: 95%

Evaluation of genotoxic and oxidative effects in workers exposed to jet propulsion fuel

Erdem

Sayal

Eken

et al. 2011

Int Arch Occup Environ Health

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Urinary 1-and 2-naphthol levels of exposed workers were found to be significantly higher than those of control subjects. Occupational exposure to JP-8 resulted in no significant genotoxic and oxidative effects, while smoking is the principal confounding factor for the some parameters. To understand the genotoxic and oxidative effects of JP-8 exposure, further studies should be planned to find out whether human populations may be at increased risk for cancer because of the exposures related to occupation and lifestyle.

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Section: Discussionsupporting

confidence: 95%

Evaluation of genotoxic and oxidative effects in workers exposed to jet propulsion fuel

Erdem

Sayal

Eken

et al. 2011

Int Arch Occup Environ Health

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“…In those subjects tobacco smoking was the most relevant source of naphthalene exposure. Overall, Table 5 shows that not all of the studies of occupationally non-exposed subjects distinguished between smokers and non-smokers, although considerably increased naphthol concentrations can be found in the urine of smokers compared with non-smokers (a 2.5-to 14-times elevation) (Hansen et al 1994b;Jansen et al 1995;Kim et al 2001;Nan et al 2001;Preuss et al 2002). Mean values for the background burden of non-smoking subjects were found to lie below 5 lg/l [lg/g creatine (lg/g cr.)]…”

Section: Environmental Internal Exposurementioning

confidence: 91%

“…Over the past years several analytical methods for the determination of either 1-naphthol or 2-naphthol, or even both together, in human or animal urine have been developed. Apart from one method that used thin-layer chromatography (Bieniek and Wilczok 1986), the techniques were based on high-pressure liquid chromatography (Elovaara et al 2003;Hansen et al 1992a;Kim et al 1999Kim et al , 2001Lee et al 2001;Massey et al 1995;Thompson et al 1996) and gas chromatography (Bieniek 1996(Bieniek , 1997(Bieniek , 1998Bouchard et al 2001;Hill et al 1995b;Hung et al 1992;Jansen et al 1995;Keimig and Morgan 1986;Kilanowicz et al 1999;Serdar et al 2003;Smith et al 2002;Yang et al 1999).…”

Section: Occupational Exposure To Naphthalenementioning

confidence: 99%

Naphthalene?an environmental and occupational toxicant

Preuss

Angerer

Drexler

2003

International Archives of Occupational and Environmental Health

273

149

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For many years naphthalene had been considered as a non-carcinogenic polycyclic aromatic hydrocarbon (PAH). Airborne naphthalene concentrations have always been observed to be below the limit values of various national committees, such as the threshold limit value (TLV) of the American Conference of Governmental Industrial Hygienists (ACGIH) and the MAK of the Deutsche Forschungsgemeinschaft (DFG) (10 ppm). Since 2000, when the US National Toxicology Program revealed clear evidence of the carcinogenic activity of naphthalene in rats, international agencies [the International Agency for Research on Cancer (IARC), the US Environmental Protection Agency (US EPA), DFG] have reclassified naphthalene as a potential human carcinogen, and the European Union (EU) is currently preparing a new risk assessment report. It is presently unknown how to protect humans from health risks resulting from occupational and environmental naphthalene exposure. Knowledge about the external and internal exposure of humans serves as the key determinant in a comprehensive risk assessment. We review here ambient monitoring studies concerning the external naphthalene exposure that results from ubiquitous environmental sources (indoor and outdoor air, water, soil, food) and from a variety of critical workplaces (coking plants, creosote impregnation, distillation of coal tar and naphthalene, manufacture of refractories, graphite electrodes, aluminium and mothballs). Based on results of ambient monitoring studies published so far, a new hygiene-based exposure limit of 1.5 mg naphthalene per cubic metre of air (0.3 ppm) is proposed. Furthermore, results from biological monitoring studies are summarised in this article. The internal burden was almost exclusively determined by means of the urinary metabolites 1-naphthol and 2-naphthol, but it is currently not possible for one to evaluate a biological tolerance level (BAT) or a biological exposure index (BEI). Based on the toxicokinetics and metabolism of naphthalene, the central question on its carcinogenicity is briefly sketched. Naphthoquinones play an important role in this context. Their adducts with macromolecules may be the parameters of choice for the estimation of effects to human health.

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“…Since naphthalene is a constituent of cigarette smoke, smokers have elevated levels of urinary naphthols compared to nonsmokers in control populations [Jansen et al, 1995;Yang et al, 1999;Kim et al, 2001;Nan et al, 2001]. We previously analyzed urinary levels of naphthalene and 1-and 2-naphthol, in a sample of U.S. Air Force personnel [Serdar et al, 2003].…”

Section: Introductionmentioning

confidence: 98%

Dose‐dependent production of urinary naphthols among workers exposed to jet fuel (JP‐8)

Serdar¹,

Egeghy²,

Gibson³

et al. 2004

American J Industrial Med

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Urinary 1-hydroxypyrene and 2-naphthol concentrations in male Koreans

Abstract: These results suggest that urinary 2-naphthol concentration is more sensitively affected by smoking status than urinary 1-OHP concentration and that urinary 2-naphthol is a sensitive marker for low-level inhalation of PAHs.

Cited by 99 publications

References 7 publications

Evaluation of genotoxic and oxidative effects in workers exposed to jet propulsion fuel

Evaluation of genotoxic and oxidative effects in workers exposed to jet propulsion fuel

Naphthalene?an environmental and occupational toxicant

Dose‐dependent production of urinary naphthols among workers exposed to jet fuel (JP‐8)

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