Urinalysis parameters for predicting severity in coronavirus disease 2019 (COVID-19)

Bonetti, Graziella; Manelli, Filippo; Bettinardi, Alessandra; Borrelli, Gianluca; Fiordalisi, Gianfranco; Marino, Antonio; Menolfi, Annamaria; Saggini, Sara; Volpi, Roberta; Adamini, Riccardo; Lippi, Giuseppe

doi:10.1515/cclm-2020-0576

Cited by 16 publications

(17 citation statements)

References 5 publications

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“…Viral infections of the lower urinary tract are specially detected in immuno-compromised patients and are the major cause of hemorrhagic cystitis in the solid organ and stem cell transplant recipients. [9][10][11] To define viral cystitis, the viral pathogen should be evaluated from…”

Section: Discussionmentioning

confidence: 99%

Could LUTS be early symptoms of COVID‐19

Kaya

Kartal

et al. 2020

Int J Clin Pract

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Aim To show if lower urinary tract symptoms (LUTS) could be symptoms of COVID‐19 with validated questionnaires. Methods The 96 COVID‐19 patients who were hospitalised at a tertiary centre were collected retrospectively. After the exclusion criteria, 46 patients consisted the study population. All patients then fill formed the International Prostate Symptom Score and Urinary Symptom Profile respectively. All patients responded to these questions for the three period. Results Twenty‐seven female (58.6%) and 19 male (41.4%) COVID‐19 patients answered the questions. In the male patients, while there were no statistically significant differences in the total IPSS, the voiding IPSS score, and quality of life between the three periods (P = .148; P = .933, P = .079, respectively), the storage IPSS scores had a significant difference between the three periods (P = .05). In female patients, low stream scores were similar between the three periods (P = .368). The scores of stress incontinence and an overactive bladder had a significant difference between the three periods (P = .05 and P = .05). Conclusion LUTS, especially storage symptoms, might be one of the initial symptoms of COVID‐19 and the clinicians should evaluate LUTS with other known symptoms of the virus when a patient is suspected of having COVID‐19.

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Section: Discussionmentioning

confidence: 99%

Could LUTS be early symptoms of COVID‐19

Kaya

Kartal

et al. 2020

Int J Clin Pract

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“…It is now undeniable that the managed care of patients with COVID-19 encompasses the identification of clinical and laboratory parameters, enabling accurate risk stratification of progressing toward severe or critical disease [ 2 ]. Urinary tract involvement is commonplace in patients with COVID-19, and that progressive deterioration of renal function shall be considered an unfavorable prognostic factor [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Urinary tract involvement is commonplace in patients with COVID-19, and that progressive deterioration of renal function shall be considered an unfavorable prognostic factor [ 3 ]. The clinical significance of urinalysis for predicting the severity of coronavirus disease 2019 (COVID-19) has been commonly reported recently [ 2 , 4 ]. However, the urinary levels of trace metals in patients with COVID-19 still remains to be investigated.…”

Section: Introductionmentioning

confidence: 99%

Urinary trace elements in association with disease severity and outcome in patients with COVID-19

Zeng

Zhang

Wang

et al. 2021

Environmental Research

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Background The dynamics of urinary trace elements in patients with COVID-19 still remains to be investigated. Methods A retrospective study was performed on a cohort of 138 confirmed COVID-19 patients for their urinary levels of essential and/or toxic metals including chromium, manganese, copper, arsenic, selenium, cadmium, mercury, thallium and lead according to the different disease severity (severe or non-severe) and outcome (recovered or deceased). Results Urinary concentrations of chromium, manganese, copper, selenium, cadmium, mercury and lead after creatinine adjustment were found to be higher in severe patients than the non-severe cases with COVID-19. And among the severe cases, these elements were also higher in the deceased group than the recovered group. When the weeks of the post-symptom onset were taken in account, the changes of these urinary elements were existed across the clinical course since the disease onset. These urinary elements were found to be mostly positively inter-correlated, and further positively correlated with other laboratory inflammatory parameters including serum cytokines (IL-1B, IL2R, IL6, IL8, IL10, TNFα), ferritin, and neutrophil count and white blood cell count. As a independently predictive factor, urinary creatinine-adjusted copper of ≥ 25.57 μg/g and ≥ 99.32 μg/g were associated with significantly increased risk of severe illness and fatal outcome in COVID-19, respectively. Conclusions These results suggest abnormities in urinary levels of the trace metals were tightly associated with the severe illness and fatal outcome of COVID-19.

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“…A further two papers presented data on prevalence in patients with and without diarrhoea: Chen Y. et al ( 2020) reported the detection of viral RNA in the stool of 6/7 (85.7%) patients with diarrhoea and 22/35 (62.6%) of those without (p 0.39), reported the detection of viral RNA in 5/12 (41.6%) of those with diarrhoea and 15/57 (28.3%) of those without (p 0.31). Bonetti et al (2020) noted an association between diarrhoea and the concentration of viral RNA in positive samples, although the observed positive association was not statistically significant (p 0.056). Similarly, Yin et al (2020) reported that the mean cycle threshold of positive samples from patients with diarrhoea was 31.37, as compared to 36.09 from those without.…”

Section: Association Between Diarrhoea and The Presence Of Sars-cov-2 In Faecesmentioning

confidence: 85%

“…Han M. S. et al (2020) observed the progression of concentrations, recording median and maximum concentrations in the 1st, 2nd and 3rd weeks of sampling of 10 8.0 and 10 10.3 ; 10 7.3 and 10 9.0 , and 10 7.6 and 10 8.7 ; the values across all subsequent sampling were 10 7.6 and 10 8.6 /ml. Some authors reported only cycle thresholds, rather than concentrations (Young et al, 2019;Bonetti et al, 2020;Kujawski et al, 2020;Wu et al, 2020a). Of these, Wu et al (2020a) provided the greatest detail, showing the cycle threshold of each test conducted.…”

Section: Concentrationmentioning

confidence: 99%

What’s in the Pipeline? Evidence on the Transmission of SARS-CoV-2 via Building Wastewater Plumbing Systems

Dight

Gormley

2021

Front. Built Environ.

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There is emerging evidence of the transmission of SARS-CoV-2 via the sanitary plumbing wastewater system, a known transmission pathway of SARS-CoV-1. These events can no longer be dismissed as isolated cases, yet a lack of awareness and of basic research makes it impossible to say just how widespread this mode of transmission might be. Virus is transmitted within wastewater systems by the aerosolisation of wastewater and subsequent transport of bioaerosols on naturally occurring airflows within the piped network. Central to the debate around risk to building occupants from SARS-CoV-2 spread via wastewater plumbing systems is the question of infectivity of faeces, urine and associated aerosols. This paper presents an examination of the processes which underlie this mode of transmission, and the existing epidemiological evidence, as well as existing mitigation strategies; significant gaps in the state of the knowledge are also identified. It is hoped that this review will cultivate a wider awareness and understanding of this most overlooked of threats, and to facilitate the selection and adoption of appropriate mitigation strategies. Key gaps in the knowledge span the rate of generation of bioaerosols within the building drainage system, their composition and transport properties, and the viability and infectivity of virions and other pathogens which they carry. While much of this work will be conducted in the laboratory, we also identify a dearth of field observations, without which it is impossible to truly grasp the scale of this problem, its character, or its solution.

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Urinalysis parameters for predicting severity in coronavirus disease 2019 (COVID-19)

Cited by 16 publications

References 5 publications

Could LUTS be early symptoms of COVID‐19

Could LUTS be early symptoms of COVID‐19

Urinary trace elements in association with disease severity and outcome in patients with COVID-19

What’s in the Pipeline? Evidence on the Transmission of SARS-CoV-2 via Building Wastewater Plumbing Systems

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