Uricosuric Agents and Phenolsulfonphthalein Excretion

Newcombe, David S.; Cohen, Alan S.

doi:10.1001/archinte.1963.03860050125014

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Increased Uric Acid Excretion1

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1965

1979

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Cited by 5 publications

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“…Several effects of probenecid on the metabolism or transport of other drugs deserve special comment. Probenecid inhibits the renal excretion of paraaminohippuric acid [26], phenolsulfonphthalein [13,78,79,82], salicylic acid and its acyl and phenolic glucuronides [49,93,117,124], phlorizin and its glucuronide [18], acetazoiamide [117], dapsone and its metabolites [46], sulfinpyrazone and its parahydroxy metabolite [83], and indomethacin [98]. Each of these agents should be used with caution in subjects receiving probenecid.…”

Section: Increased Uric Acid Excretionmentioning

confidence: 99%

Pharmacologic Approach to the Maintenance of Urate Homeostasis

Kelley¹

1975

Nephron

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A reduction in the serum urate concentration in hyperuricemic subjects can be achieved by increasing the renal excretion of uric acid, by inhibiting its synthesis, or by a combination of both modalities. The three most commonly used hypouricemic drugs are probenecid, sulfinpyrazone and allopurinol. Each drug has been considered in detail with regard to its mechanism of action, metabolism, diverse metabolic effects, side effects and interaction with other drugs. In addition, guidelines for the use of these drugs in hyperuricemic subjects are proposed.

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