Uricase Modified Au/Ni/PANI Microrockets to Reduce Uric Acid Level

Crystal Facet Controlled Metal–Support Interaction in Uricase Mimics for Highly Efficient Hyperuricemia Treatment

“…Hyperuricemia caused by extremely high uric acid (UA) levels in serum can trigger many health problems, − such as gout, hypertension, diabetes, kidney stone, metabolic syndrome, and cardiovascular diseases. − Uricase, as an exogenous enzyme, can catalyze the oxidation of UA into allantoin for bioelimination. − However, uricase is immunogenic to humans, so delicate surface modification is needed for uricase-based medications, such as the PEGlyated uricase (pegloticase), which significantly complicates the production process, increases the cost, and affects the catalytic activity. − More seriously, the degradation of UA by uricase leads to the formation of hydrogen peroxide (H 2 O 2 ) as byproduct, which will increase the accumulation of reactive oxygen species (ROS) in human body and cause inflammation and other diseases in clinical treatment. − Thus, the fast uricolytic process along with the timely H 2 O 2 elimination should be achieved simultaneously for successful hyperuricemia therapy.…”