Uric Acid, Type 2 Diabetes, and Cardiovascular Diseases: Fueling the Common Soil Hypothesis?

Köenig, Wolfgang; Meisinger, Christa

doi:10.1373/clinchem.2007.099705

Cited by 43 publications

(35 citation statements)

References 16 publications

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“…The increase in serum UA levels may be linked to the rising prevalence of overweight and obesity, as well as, the increased consumption of sugar-sweetened beverages, foods rich in purine or alcohol [6,7]. Accumulating evidences show that increased UA level represents a risk factor for metabolic syndrome and cardiovascular diseases [8,9]. The causes of hyperuricemia are the result of UA underexcretion or overproduction.…”

Section: Introductionmentioning

confidence: 99%

Hyper-homocysteinemia Inducing Hyperuricemia: What are the Mechanisms?

Cacciapuoti

2017

J Rheum Dis

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Hyperuricemia is related to metabolic syndrome, and is defined as an over-production or under-excretion of uric acid (UA), with increased UA serum concentration. Among other causes, Hyper-homocysteinemia (H-Hcy) can be responsible for hyperuricemia. The mechanisms underlying the association between these two conditions are unclear, but increased UA serum levels can be a consequence of renovascular atherosclerosis, with reduced UA excretion. An alternative hypothesis is the overproduction of UA from adenosine (originating from S-adenosyl-homocysteine). Genetic polymorphism (C677T) of methylenetetrahydrofolate reductase (MTHFR) may contribute. A possible mechanism is purines biosyinthesis originating from this gene variant. However, the results obtained from several studies and meta-analyses of the relationship between H-Hcy and hyperuricemia are ambivalent, and broader research is needed. (J Rheum Dis 2017;24:127-130)

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Section: Introductionmentioning

confidence: 99%

Hyper-homocysteinemia Inducing Hyperuricemia: What are the Mechanisms?

Cacciapuoti

2017

J Rheum Dis

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“…10 Thus, uric acid fluctuations during Pre-diabetes and Diabetes have so far been regarded as a secondary metabolic phenomenon. A previous study conducted by Koenig W (2008) 19 reported that serum uric acid has been shown to be associated with oxidative stress and production of Tumor necrosis factor-a, both of which are related to development of Diabetes. Elevated serum uric acid levels may reflect Prediabetes status particularly at the renal level.…”

Section: Discussionmentioning

confidence: 99%

A Cross Sectional Study Showing Association of Serum Uric Acid in PreDiabetic and Diabetic Indian Population

Sachan¹

2018

jmscr

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“…Some researchers have proposed that hyperuricemia-induced oxidative stress represents a cause of the metabolic syndrome 75,76 . Hyperuricemia has been found to be associated with obesity and insulin resistance, and consequently with type 2 diabetes 75,77,78 .…”

Section: Uric Acid and Type 2 Diabetesmentioning

confidence: 99%

“…Hyperuricemia has been found to be associated with obesity and insulin resistance, and consequently with type 2 diabetes 75,77,78 .…”

Section: Uric Acid and Type 2 Diabetesmentioning

confidence: 99%

Ürik Asidin Antioksidan ve Pro-Oksidan Özellikleri ile İlgili Kavram ve Tartışmalarının Derlemesi

Kumar¹,

Aruna²,

Naidu³

et al. 2015

Arşiv Kaynak Tarama Dergisi

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Uric acid, the end product of purine catabolism in humans and is known for its crystal deposition at higher concentrations (>7 mg/dl) in gout. Less is known about its antioxidant property and the beneficial effects in various diseases. It is thought that high concentration of uric acid in humans is an evolutionary advantage and it is also hypothesized that high concentration of uric acid is to compensate the antioxidant capacity of ascorbic acid which is lost in humans during the course of evolution. In the extracelluar environment, uric acid can scavenge free radicals like hydroxyl radical, singlet oxygen and peroxynitrite radical therefore, it is considered as a powerful antioxidant. On the other hand uric acid depending upon the chemical milieu, changing its property and at times it acts as pro oxidant and is associated with the pathobiochemistry in developing various diseases like hypertension, cardio vascular diseases, ischemia reperfusion injury, diabetes mellitus, non alcoholic fatty liver disorders etc. In this review, we tried to summarize the evolutionary advantages of hyperuricaemia, effects of both antioxidant property and pro-oxidant nature of uric acid in various disease conditions.

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Uric Acid, Type 2 Diabetes, and Cardiovascular Diseases: Fueling the Common Soil Hypothesis?

Cited by 43 publications

References 16 publications

Hyper-homocysteinemia Inducing Hyperuricemia: What are the Mechanisms?

Hyper-homocysteinemia Inducing Hyperuricemia: What are the Mechanisms?

A Cross Sectional Study Showing Association of Serum Uric Acid in PreDiabetic and Diabetic Indian Population

Ürik Asidin Antioksidan ve Pro-Oksidan Özellikleri ile İlgili Kavram ve Tartışmalarının Derlemesi

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