Uric Acid, Phosphate and Oxalate Stones: Treatment and Prophylaxis

Caramia, G; Gregorio, L. Di; Tarantino, María; Galuffo, Antonino; Iacolino, R.; Caramia, M.

doi:10.1159/000076587

Cited by 11 publications

(5 citation statements)

References 12 publications

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“…Recently, there was emerging evidence indicating that uric acid calculi became more prevalent among patients with obesity, T2DM, and metabolic syndrome [ 11 , 25 ]. This suggested that the pathogenetic formation of uric acid calculi could not merely be derived from abnormalities in uric acid metabolism but also be attributed to dietary habits and lifestyle [ 26 , 27 ]. According to the literature, uric acid calculi were associated with obesity, metabolic syndrome, and T2DM [ 11 – 13 , 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

The Association of Uric Acid Calculi with Obesity, Prediabetes, Type 2 Diabetes Mellitus, and Hypertension

Chu

Chang

Huang

et al. 2017

BioMed Research International

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Objectives To disclose the link between the composition of urolithiasis, especially that of uric acid calculi, and obesity, prediabetes, type 2 diabetes mellitus, and hypertension. Materials and MethodsPatients who had urinary calculi and underwent surgical treatment were registered in the study. The composition of urinary calculi was analyzed and correlated with clinical features and biomedical profiles of the patients before surgical intervention. Results A total of 666 patients with urolithiasis who underwent surgical management were registered and analyzed. In those who had uric acid calculi, there was a significant association with prediabetic (OR: 20.11, 95% CI: 7.40–54.63, P < 0.001) and diabetic states (OR: 11.55, 95% CI: 4.41–29.97, P < 0.001). It also seemed that uric acid calculi were related to obesity but there was no statistical significance (OR: 2.45, 95% CI: 0.91–6.62, P = 0.078). There was no association of uric acid calculi with hypertension (OR: 1.08, 95% CI: 0.54–2.17, P = 0.822) and concurrent urinary tract infection (OR: 0.93, 95% CI: 0.44–1.96, P = 0.841). Conclusion There was a remarkable association of uric acid calculi with prediabetic and diabetic states. The uric acid calculi were also seemingly associated with obesity in patients with urolithiasis undergoing surgical management.

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Section: Discussionmentioning

confidence: 99%

The Association of Uric Acid Calculi with Obesity, Prediabetes, Type 2 Diabetes Mellitus, and Hypertension

Chu

Chang

Huang

et al. 2017

BioMed Research International

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“…In preclinical experiments, it was confirmed that Rowatinex has antilithogenic, antibacterial, anti-inflammatory, spasmolytic, and analgesic properties [14, 15]. The antilithogenic property, which influences renal oxalate lithogenesis, is important because most urinary stones are composed of calcium oxalate aggregates.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Terpene Combination on Ureter Calculus Expulsion After Extracorporeal Shock Wave Lithotripsy

et al. 2014

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PurposeTerpene combination (Rowatinex) is known to help with the expulsion of urinary stones. The aim of this study was to determine how Rowatinex affects the expulsion of remnant stones after shock wave lithotripsy (SWL).Materials and MethodsClinical data were collected retrospectively from 499 patients with a diagnosis of ureteral stones who underwent SWL from January 2009 to August 2012. Ureteral stones were diagnosed in all patients by kidney, ureter, and bladder x-ray and abdominal computed tomography (CT). The progress of patients was documented every 2 weeks to confirm remnant stones after SWL. The patients with remnant stones underwent SWL again. Group 1 consisted of patients who were prescribed an analgesic, Tamsulosin 0.2 mg, and Rowatinex. Group 2 consisted of patients who were prescribed only an analgesic and Tamsulosin 0.2 mg. The expulsion rate of urinary stones was compared between groups.ResultsThe expulsion rate of urinary stones was not significantly different between the two groups after 2 weeks. However, after 4 weeks, group 1 had a significantly higher expulsion rate (72.2% compared with 61.1%, p=0.022). Fifteen patients (10.2%) in group 1 and 40 (11.4%) in group 2 had to undergo ureteroscopic removal of the stone (p=0.756). Acute pyelonephritis occurred in one patient (0.7%) in group 1 and in one patient (0.3%) in group 2 (p=0.503).ConclusionsThe long-term administration of Rowatinex for 4 weeks increased the expulsion rate of urinary stones after SWL.

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“…1 = Continental breakfast/soup/soup; 2 = fasting/ fasting/fasting; 3 = fasting/fasting/dinner; 4 = continental breakfast/lunch/soup; 5 = continental breakfast/lunch/dinner; 6 = fasting/lunch/dinner. further treatment or other measures are needed to render the patients stone free [3,[12][13][14] . Retreatment rates after primary ESWL are significantly correlated with stone burden and location.…”

Section: Discussionmentioning

confidence: 99%

Age-Related Changes of Urine Calcium Excretion after Extracorporeal Shock Wave Lithotripsy due to Artificial Renal Calcium Leakage

Oehlschläger

Hakenberg²,

Froehner³

et al. 2008

Urol Int

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Introduction: Extracorporeal shock wave lithotripsy (ESWL) is the standard stone treatment. Increased excretion of tubular enzymes and hypercalciuria has been reported after ESWL. We investigated the importance of renally induced hypercalciuria after ESWL. Material and Methods: 30 calcium oxalate stoneformers (23 men, 7 women), mean age 53.3 (range 30–71) years, were evaluated prospectively. Plasma calcium and creatinine concentrations and 8-hour overnight urine were measured before ESWL and on the 1st and 2nd days after ESWL. To estimate the changes of tubular reabsorption, the calcium/creatinine clearance ratios were calculated. Results: Hypercalciuria (>5 mmol/24 h) was seen in 5/30 (16.7%) before, in 12/30 (40.0%) on day 1 and in 13/30 (43.3%) on day 2 after ESWL. The mean plasma levels of calcium were significantly decreased from 2.36 mmol/l before to 2.28 mmol/l on day 2 after ESWL (p< 0.01). The mean calcium/creatinine clearance ratio was significantly increased from 0.012 before to 0.019 after ESWL (p< 0.01). Before and on day 2 after ESWL, the calcium/creatinine clearance ratio was significantly correlated with the age of the patients (r = 0.33, p< 0.04). Conclusion: Our data show an age-related significantly increased urine calcium excretion after ESWL possibly due to decreased tubular calcium reabsorption.

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Uric Acid, Phosphate and Oxalate Stones: Treatment and Prophylaxis

Cited by 11 publications

References 12 publications

The Association of Uric Acid Calculi with Obesity, Prediabetes, Type 2 Diabetes Mellitus, and Hypertension

The Association of Uric Acid Calculi with Obesity, Prediabetes, Type 2 Diabetes Mellitus, and Hypertension

The Effect of Terpene Combination on Ureter Calculus Expulsion After Extracorporeal Shock Wave Lithotripsy

Age-Related Changes of Urine Calcium Excretion after Extracorporeal Shock Wave Lithotripsy due to Artificial Renal Calcium Leakage

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