Uric acid levels and clearance in chronic kidney disease patients

Abstract

Introduction. Uric acid levels increase in chronic renal failure especially due to protein metabolism. In this study, we aimed to compare uric acid clearance who are also nephrotoxic in patients with end-stage renal disease. Methods. Sixty-one chronic peritoneal dialysis (PD) patients and fifty-one chronic hemodialysis (HD) patients were included in the study. Clinical and laboratory characteristics of PD and HD patients were compared. Duration of PD and HD, uric acid levels, age and gender of the patients evaluated. Uric acid levels in PD patients and HD patients compared. Results. The mean ages of PD and HD patients were 56.7±13.5 and 57.2±16.4 years, respectively (p=0.864). The number of male patients was more in PD group and female in HD group (p=0.959). Duration of dialysis was 3.25 years in PD and 3.75 years in HD (p=0.925). The mean serum uric acid levels were 5.54±1.13 mg/dL in PD patients, and 5.76 ±1.52 mg/dL in HD patients (p=0.389). Conclusions. Dialysis is used to remove toxins in end-stage renal disease. Uric acid levels may be elevated in patients with end-stage renal disease. However, there was no difference in serum uric acid levels in PD and HD patients in our study.