Uric Acid Levels and All-Cause Mortality in Peritoneal Dialysis Patients

Feng, Sheng; Jiang, Linseng; Shi, Yongyu; Shen, Huaying; Shi, Xin; Jin, Donghua; Zeng, Ying; Wang, Zhi

doi:10.1159/000350143

Cited by 51 publications

(65 citation statements)

References 23 publications

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“…This finding was inconsistent with the results of Feng in China (32). The reason may be associated with the difference in the ethnicity or China status as a developing country.…”

Section: Discussioncontrasting

confidence: 85%

Relation of Serum Uric Acid With C-reactive Protein and Ferritin Levels in Patients Undergoing Hemodialysis

Biniaz

Shermeh

Tayebi

et al. 2014

Jundishapur J Chronic Dis Care

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Background:Clinical studies have shown that precipitation of urate crystals in joints of hyperuricemic patients could lead to systemic inflammation; however, this subject has been little explored in patients undergoing hemodialysis. Objectives: We carried out this study in order to evaluate the association of serum uric acid (SUA) levels with plasma concentrations of CRP, an inflammatory marker, and ferritin in hemodialysis patients. Materials and Methods:This cross-sectional study was conducted on 182 hemodialysis patients in two hemodialysis wards in Iran. Required laboratory parameters, including serum levels of uric acid, C-reactive protein, lipid profiles (cholesterol, triglyceride, HDL, LDL), and ferritin were measured. Demographic data were also collected with the self-report survey. P Value less than 0.05 is considered significant. Results: Higher serum levels of uric acid and CRP were seen in 44% and 47% of the patients, respectively. Hyperferritinemia was observed in 80% of participants. Although there was a significant relationship between SUA level and plasma triglyceride (P = 0.007), a linear correlation indicated that SUA level had no significant association with CRP and ferritin. Conclusions: Our results indicated that there is no statistical relationship between SUA level and CRP and serum ferritin. Detailed investigations with larger sample size are recommended.

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“…This finding was inconsistent with the results of Feng in China (32). The reason may be associated with the difference in the ethnicity or China status as a developing country.…”

Section: Discussioncontrasting

confidence: 85%

Relation of Serum Uric Acid With C-reactive Protein and Ferritin Levels in Patients Undergoing Hemodialysis

Biniaz

Shermeh

Tayebi

et al. 2014

Jundishapur J Chronic Dis Care

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show abstract

“…Each 1 mg/dL (0.06 mmol/L) increase in uric acid level was associated with higher adjusted allcause mortality (HR 1.05, 1.00-1.10) and CVD mortality (HR 1.12, 1.05-1.20). Similar results have been found by other authors [137,138].…”

Section: Latif Et Al Reviewed Dopps Data and Found That Higher Uric supporting

confidence: 93%

Cardiovascular Disease in Dialysis Patients

Jegatheesan¹,

Yang²,

Krishnasamy³

et al. 2018

Aspects in Dialysis

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Cardiovascular disease (CVD) is highly prevalent in the dialysis population, affecting up to 60% of cohorts. Cardiovascular mortality rates are reported to be ~14 per 100 patient-years, which are 10-to 20-fold greater than those of age-and gender-matched controls. CVD is the primary cause of death in up to 40% of dialysis patients in Australia, New Zealand and the United States. Dialysis patients endure a greater burden of both traditional risk factors for CVD and risk factors related to loss of kidney function that may account for the higher CVD morbidity and mortality. Many cardiology guidelines include chronic kidney disease (CKD) and end-stage kidney disease (ESKD) as coronary heart disease (CHD) risk equivalents. It is therefore important for clinicians to both recognise and optimise the cardiovascular health of patients receiving maintenance dialysis. This chapter will focus on risk factor modification, screening and prevention of CVD in dialysis patients.

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“…Cardiovascular disease continues to be a common complication and be the leading cause of morbidity and mortality among people with CKD [13]. The rates of cardiovascular events and mortality consistently increase as kidney function declines [14].…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Endothelial Dysfunction and Left Ventricular Remodeling in Patients with Chronic Kidney Disease

Peng¹,

Zhao²,

Wu³

et al. 2014

Kidney Blood Press Res

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Background/Aims: To investigate the role of endothelial dysfunction on left ventricular remodeling in patients with chronic kidney disease and to evaluate the correlation between endothelial dysfunction and left ventricular remodeling. Methods: Seventy-three patients with chronic kidney disease as study-group and thirty healthy volunteers as control-group were enrolled in the present study. All patients in both groups had echocardiography examination. The concentration of endothelin-1, nitric oxide, and inducible nitric oxide synthase of serum of all patients and healthy volunteers was measured. The incidence of cardiac structural abnormalities in patients with chronic kidney disease, and the relationship between endothelial dysfunction and cardiac structural abnormalities were analyzed. Results: The incidence of left ventricular hypertrophy, left ventricular concentric remodeling, and left ventricular systolic dysfunction was 65%, 8.33%, and 16.67%, respectively. The level of endothelin-1 and nitric oxide increased in study-group, and the concentration of inducible nitric oxide synthase decreased. There was significant positively relationship between plasma endothelin-1 and left ventricular mass index, interventricular septal thickness, left ventricular diastolic diameter. There was negatively relationship between the level of serum nitric oxide and the maximum flow velocity at the mitral in left ventricular diastolic stage. There was not any correlation between inducible nitric oxide synthase with left ventricular remodeling. Conclusions: The results showed that there was a higher incidence of left ventricular hypertrophy in patients with chronic kidney disease. Endothelin-1 and nitric oxide played an important role on the development of left ventricular hypertrophy. i 2014 S. Karger AG, Basel

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Uric Acid Levels and All-Cause Mortality in Peritoneal Dialysis Patients

Cited by 51 publications

References 23 publications

Relation of Serum Uric Acid With C-reactive Protein and Ferritin Levels in Patients Undergoing Hemodialysis

Relation of Serum Uric Acid With C-reactive Protein and Ferritin Levels in Patients Undergoing Hemodialysis

Cardiovascular Disease in Dialysis Patients

Correlation Between Endothelial Dysfunction and Left Ventricular Remodeling in Patients with Chronic Kidney Disease

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