Uric Acid Level and Prevalence of Atrial Fibrillation in a Japanese General Population of 285,882

Kawasoe, Shin; Kubozono, Takuro; Yoshifuku, Shiro; Ojima, Satoko; Oketani, Naoya; Miyata, Masaaki; Miyahara, Hirofumi; Maenohara, Shigeho; Ohishi, Mitsuru

doi:10.1253/circj.cj-16-0766

Cited by 37 publications

(28 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have investigated serum uric acid levels in Japanese adults. Reported serum uric acid levels for men and women are respectively, 6.2 and 4.4 mg/dL [13], 5.9 and 4.2 mg/dL [14], 6.5 and 4.7 mg/dL [15], and 6.0 and 4.5 mg/dL [21]. Therefore, our findings of higher serum acid levels in men were similar to these findings.…”

Section: Discussionsupporting

confidence: 87%

Cross-sectional study of associations between normal body weight with central obesity and hyperuricemia in Japan

Shirasawa

Ochiai

Yoshimoto

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Several studies have shown that normal weight with central obesity (NWCO) is associated with cardiovascular disease risk factors such as hypertension, dyslipidemia and diabetes. However, the relationship between NWCO and hyperuricemia has not been studied in detail. Methods: We investigated the association between NWCO and hyperuricemia among Japanese adults aged 40-64 years who had undergone periodic health examinations between April 2013 and March 2014. Obesity was defined as a body mass index (BMI) ≥25 kg/m2　and central obesity was determined as a waist-to-height ratio (WHtR) ≥0.5. We classified the participants into the following groups based according to having obesity and central obesity: normal weight (BMI 18.5-24.9 kg/m2) without (NW; WHtR <0.5) and with (NWCO) central obesity, and obesity without (OB) and with (OBCO) central obesity. Hyperuricemia was defined as serum uric acid >7.0 and ≥6.0 mg/dL in men and women, respectively, or under medical treatment for hyperuricemia. Alcohol intake was classified as yes (daily and occasional consumption) and none (no alcohol consumption). Odds ratios (OR) and 95% confidence intervals (CI) for hyperuricemia were calculated using a logistic regression model. Results: We analyzed data derived from 96,863 participants (69,241 men and 27,622 women). The prevalences of hyperuricemia in men and women were respectively, 21.4% and 11.0%, and of participants with NWCO respectively 15.6% and 30.0%. The adjusted OR for hyperuricemia was significantly increased in OBCO compared with NW, regardless of sex (men: OR, 2.12; 95%CI; 2.03-2.21; women: OR, 3.54; 95%CI, 3.21-3.90) and were statistically significant in NWCO compared with NW (men: OR, 1.44; 95%CI, 1.36-1.52; women: OR, 1.41; 95%CI, 1.27-1.57). The results were similar regardless of alcohol consumption. Conclusions: We found that NWCO and OBCO were associated with hyperuricemia in middle-aged Japanese men and women. Middle-aged Japanese adults with normal weight but having central obesity should be screened using a combination of BMI and WHtR and educated about how to prevent hyperuricemia.

show abstract

Section: Discussionsupporting

confidence: 87%

Cross-sectional study of associations between normal body weight with central obesity and hyperuricemia in Japan

Shirasawa

Ochiai

Yoshimoto

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…In another study, Letsas et 16 . A positive correlation between SUA and AF, independent of sex and other cardiovascular risk factors, was found in a Japanese general population study 17 . A meta-analysis of six cohort studies showed that hyperuricemia was significantly associated with increased risk of AF (relative risk (RR) ¼ 1.49, 95% CI ¼ 1.24À1.79, p < .001) 18 ( Figure 2).…”

Section: Introductionmentioning

confidence: 77%

Serum uric acid and atrial fibrillation

Manolis¹

2017

Current Medical Research and Opinion

View full text Add to dashboard Cite

Background: Atrial fibrillation (AF) represents a significant health concern, due to the increased prevalence, morbidity, and mortality. Methods and Results: There is a growing body of evidence correlating serum uric acid (SUA) with cardiovascular diseases such as arterial hypertension and AF. Conclusion: Thus, a question arises as to whether SUA levels have a role in the pathophysiology of AF development.

show abstract

“…Future studies with repeated SUA measurements will help to estimate the consistency of a single measurement. Finally, as this was a post hoc analysis of a hypertensive cohort, we compared the SUA levels in our cohort to that of a Japanese general population and found the SUA levels in our cohort to be 0.3 and 0.6 mg/dl higher in men and women, respectively. However, this does not influence our conclusion as we defined low and high SUA according to the levels in our cohort.…”

Section: Discussionmentioning

confidence: 99%

Association of serum uric acid with increased risk of cancer among hypertensive Chinese

Yang

Wang

Zhao

et al. 2017

Intl Journal of Cancer

View full text Add to dashboard Cite

Several large prospective studies show an association between serum uric acid (SUA) and cancer, however there is a lack of evidence in China. We aimed to investigate the effects of SUA levels on cancer incidence and mortality in China. This study included 20,577 adult hypertensive patients with valid SUA measurements who participated in the China Stroke Primary Prevention Trial where subjects were randomly assigned to receive a double-blind treatment of either 10 mg enalapril (n = 10,286) or 10.8 mg enalapril-folic acid (n = 10,291). Subjects were prospectively followed for a median of 4.5 years. Cox proportional hazards models were used to calculate hazards ratios (HR) of cancer risk associated with SUA. A total of 232 participants developed cancer. SUA was independently associated with increased cancer risk in the enalapril group [HR: 1.12, (95% CI: 1.03-1.22)]. Compared to the lowest tertile, combined subjects with SUA levels from the upper two tertiles had a higher risk of cancer in the enalapril group [T2 + T3: HR: 1.58, (95% CI: 1.02-2.47)]. In cancer site-specific analyses, a positive association of SUA levels with digestive cancer and all fatal cancer was also observed [HR: 1.18, (95% CI: 1.09-1.27); HR: 1.15, (95% CI: 1.03-1.28), respectively] in the enalapril group. Interestingly, SUA levels were not associated with the risk of cancer or related mortality in the enalapril folic acid group. Our results suggest that elevated SUA is independently and positively associated with the risk of total cancer incidence, digestive cancer incidence and cancer mortality among hypertensive Chinese.

show abstract

Uric Acid Level and Prevalence of Atrial Fibrillation in a Japanese General Population of 285,882

Cited by 37 publications

References 48 publications

Cross-sectional study of associations between normal body weight with central obesity and hyperuricemia in Japan

Cross-sectional study of associations between normal body weight with central obesity and hyperuricemia in Japan

Serum uric acid and atrial fibrillation

Association of serum uric acid with increased risk of cancer among hypertensive Chinese

Contact Info

Product

Resources

About