2018
DOI: 10.1093/ndt/gfy076
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Uric acid is not associated with diabetic nephropathy and other complications in type 1 diabetes

Abstract: In type 1 diabetes patients, higher UA was associated with lower kidney function and other diabetic complications. The association between higher UA and lower eGFR and lower diastolic BP was independent of traditional risk factors.

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Cited by 19 publications
(25 citation statements)
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“…Between 2009 and 2011, Caucasian patients with type 1 diabetes were recruited to enter a cross-sectional study at Steno Diabetes Center Copenhagen. The details of the study have been previously described (5,11,12). The cohort was stratified by levels of albuminuria (normoalbuminuria, microalbuminuria, and macroalbuminuria) regardless of the presence of retinopathy.…”
Section: Participantsmentioning
confidence: 99%
See 1 more Smart Citation
“…Between 2009 and 2011, Caucasian patients with type 1 diabetes were recruited to enter a cross-sectional study at Steno Diabetes Center Copenhagen. The details of the study have been previously described (5,11,12). The cohort was stratified by levels of albuminuria (normoalbuminuria, microalbuminuria, and macroalbuminuria) regardless of the presence of retinopathy.…”
Section: Participantsmentioning
confidence: 99%
“…Studies have shown that elevated uric acid levels independently predict the incidence and development of chronic kidney disease both in patients without diabetes and in patients with diabetes (2)(3)(4). However, other studies have not been able to confirm these findings (5)(6)(7).…”
mentioning
confidence: 99%
“…It should be noted that the statistical models are different in the two analyses of the same cohort. In the previous study, the data on annual decline in eGFR in the highest UA quartile were compared with the three lower quartiles (2). However, in the present study (1), hazard ratios were calculated per doubling of UA.…”
mentioning
confidence: 80%
“…Furthermore, statistical significance may change in different analysis models, and results should be interpreted with caution. It is interesting that in another recently published article on the same cohort (2), no association was found between UA and decline in estimated glomerular filtration rate (eGFR). The research group considered that the difference in these results may be explained by the larger sample size (a rise from 476 patients to 510 patients with eGFR follow-up data) and increase in the follow-up period from 4.1 to 5.3 years (2).…”
mentioning
confidence: 99%
“…Son yıllarda ürik asit düzeyi ile diyabet ve komplikasyonları arasındaki ilişkiyi inceleyen çalışmalar yayınlanmış olup bu çalışmaların sonuçlarının birbiri ile tutarsız olduğu ve tartışmaların devam ettiği görülmektedir 5,[9][10][11]13 . T1DM hastalarında SÜA düzeyini ve ürik asidin komplikasyonlarla ilişkisini inceleyen az sayıda çalışma mevcuttur.…”
Section: Tartışma Ve Sonuçunclassified