Uric acid is associated with vascular dementia in Chinese population

Xu, Yuzhen; Wang, Qian; Cui, Ruiting; Lu, Kaili; Liu, Yunling; Zhao, Yuwu

doi:10.1002/brb3.617

Cited by 23 publications

(22 citation statements)

References 39 publications

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“…In our study, we found that the patients in Q4 group (SUA > 501.8 μmol/L) had lowest MMSE scores. However, on the contrary, previous research showed that SUA level was lower in those with mild cognitive impairment (MCI), Alzheimer's disease (AD), and vascular dementia when compared with cognitively healthy controls (Khan, Quinn, Hewitt, Fan, & Dawson, ; Xu et al, ). It may be associated with different spectrum of diseases.…”

Section: Discussionmentioning

confidence: 89%

Uric acid is associated with cognitive impairment in the elderly patients receiving maintenance hemodialysis—A two‐center study

Tang

Wang

et al. 2020

Brain and Behavior

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Background Elevated serum uric acid (SUA) has been associated with vascular cognitive impairment (CI) in the elderly. However, its relationship with cognitive function in the elderly patients receiving maintenance hemodialysis (MHD) has not yet been elucidated. Objective The cognitive impairment is prevalent in MHD patients. Various insults may contribute to cognitive impairment in patients with MHD. The aim of this study was to investigate the relationship between SUA and CI in the elderly patients receiving MHD. Methods A total of 180 elderly MHD subjects from two hospitals were enrolled in our study. Cognitive function domains were evaluated by MMSE at the beginning of the trial. Demographic and clinical characteristics were collected and recorded. Results The subjects were stratified into quartiles according to SUA level. Demographic and clinical characteristics such as age, gender, smoking habit, education year, blood pressure (BP), hemoglobin, albumin, blood glucose (BG), total cholesterol (TC), triglycerides (TG), high‐density lipoprotein cholesterol (HDL), low‐density lipoprotein cholesterol (LDL), blood urea nitrogen (BUN), and serum creatinine (Scr) did not differ dramatically among groups (p > .05). The Q1 group showed the highest MMSE scores, and the Q4 group showed the lowest MMSE sores (p < .05). There was a negative correlation between SUA and MMSE scores (r = −.307, p = .014), and this correlation was independent of demographic and clinical characteristics. Conclusions Elevated SUA maybe contributes to CI in the elderly MHD patients. SUA level is independent risk for the CI in the elderly MHD patients.

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Section: Discussionmentioning

confidence: 89%

Uric acid is associated with cognitive impairment in the elderly patients receiving maintenance hemodialysis—A two‐center study

Tang

Wang

et al. 2020

Brain and Behavior

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“…The antioxidant properties of uric acid may reduce the burden of cellular oxidation, a major cause of neurodegenerative diseases [1]. In line with this, previous research shows that SUA levels are lower in those with mild cognitive impairment (MCI), Alzheimer’s disease (AD), and vascular dementia when compared with cognitively healthy controls [2–4]. The association between SUA and cognitive performance in middle-aged and older adults remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Sex-Dependent Associations of Serum Uric Acid with Brain Function During Aging

Kueider‐Paisley

Tanaka

et al. 2017

JAD

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Serum uric acid (SUA) is an abundant natural antioxidant capable of reducing cellular oxidation, a major cause of neurodegenerative disease. In line with this, SUA levels are lower in Alzheimer’s disease; however, the association between SUA and cognition remains unclear. Results from studies examining the effects of SUA on cognition may be difficult to interpret in the context of normal versus pathological aging. This study examined sex-specific associations of baseline SUA with cognition during aging. Data from dementia-free participants initially aged 26–99 (N = 1,451) recruited for the Baltimore Longitudinal Study of Aging (BLSA), were used in the current analyses. SUA was assessed using blood samples collected during research visits. Cognition was measured using five composite scores (verbal memory, attention, executive function, language, and visuospatial ability). At the first study visit, compared with women, men were older, more likely to be White, had more years of education, higher baseline SUA levels, and higher cardiovascular risk scores. Higher baseline SUA was associated with attenuated declines in attention (β = 0.006; p = 0.03) and visuospatial abilities (β = 0.007; p = 0.01) in men. There was a trend to suggest higher baseline SUA in men was associated with attenuated declines in language, but this finding did not reach statistical significance (p = 0.09). There were no significant findings with SUA and cognition in women. In this sample of cognitively healthy, community-dwelling adults, we found that higher SUA levels at baseline were associated with attenuated declines in attention and visuospatial abilities in men. SUA was not associated with cognition or change in cognition over time in women.

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“…There are no less than 50 million people suffering from dementia globally; this number is predicted to have a threefold increase by 2050 [ 5 , 6 ]. Growing with age, the risk of VaD almost doubled every 3–5 years [ 7 ]. With the increase in human life expectancy and the advent of aging, VaD has emerged as one of the leading health problems in society [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia

Song

et al. 2020

Disease Markers

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Objective. Family with sequence similarity 19 member A5 (FAM19A5), a novel chemokine-like peptide, is a secreted protein mainly expressed in the brain. FAM19A5 was recently found to be involved in a variety of neurological diseases; however, its correlation with vascular dementia (VaD) remains unclear. The aim of the study is to explore the association between serum FAM19A5 and cognitive impairment in subjects with VaD. Method. 136 VaD subjects and 81 normal controls were recruited in the study. Their demographic and clinical baseline data were collected on admission. All subjects received Mini-Mental State Examination (MMSE) evaluation, which was used to test their cognitive functions. A sandwich enzyme-linked immunosorbent assay (ELISA) was applied to detect the serum levels of FAM19A5. Results. No significant differences were found between the two groups regarding the demographic and clinical baseline data (p>0.05). The serum FAM19A5 levels were significantly higher compared to normal controls (p<0.001). The Spearman correlation analysis indicated that serum FAM19A5 levels and MMSE scores have a significant negative correlation in VaD patients (r=−0.414, <0.001). Further multiple regression analysis indicated that serum FAM19A5 levels were independent risk predictors for cognitive functions in VaD (β=0.419, p=0.031). Conclusion. The serum FAM19A5 level of VaD patients is significantly increased, which may serve as a biomarker to predict cognitive function of VaD.

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Uric acid is associated with vascular dementia in Chinese population

Cited by 23 publications

References 39 publications

Uric acid is associated with cognitive impairment in the elderly patients receiving maintenance hemodialysis—A two‐center study

Uric acid is associated with cognitive impairment in the elderly patients receiving maintenance hemodialysis—A two‐center study

Sex-Dependent Associations of Serum Uric Acid with Brain Function During Aging

Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia

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