Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study

Abstract

Background: The role of serum uric acid as an independent predictor of cardiovascular disease and death is uncertain in the general population. Adjustments for additional cardiovascular risk factors have not been consistent. We examined the association of serum uric acid with all-cause mortality, ischemic stroke and myocardial infarction in a prospective population based study, with several traditional and non-traditional risk factors for cardiovascular disease included in the model. Methods: A population-based prospective cohort study was performed among 2696 men and 3004 women. Endpoints were all-cause mortality after 15 years, and fatal or non-fatal myocardial infarction (MI) and ischemic stroke after 12 years. Results: 1433 deaths, 659 MIs and 430 ischemic strokes occurred during follow-up. Fully adjusted Cox regression analyses showed that per 1 SD (87 μmol/L) increase in serum uric acid level, the risk of all-cause mortality increased in both genders (hazard ratios, HR men; 1.11, 95% CI 1.02-1.20, women; 1.16, 1.05-1.29). HRs and 95% CI for stroke were 1.31, 1.14-1.50 in men, 1.13, 0.94-1.36 in women, and 1.22 (1.09, 1.35) in the overall population. No independent associations were observed with MI.

Cardiovascular screening programme in the Central Hungarian region. The Budakalász Study

“…Az elmúlt időszakban a rizikóbecslés pontosítása, minél inkább személyre szabása érdekében intenzív kutatá-sok folynak további rizikótényezők felderítésére. Egyes laboratóriumi paramétereket összefüggésbe hoztak a fokozott rizikóval, ezek egy része például az endotheldiszfunkcióra (albumin/kreatinin hányados [5], szérum-húgysavszint [6,7], homocisztein [8]), másik része a háttérben zajló gyulladásos folyamatra (hsCRP [9], fi brinogén [10], csökkent D-vitamin-szint [11]) utal, illetve ismertek olyan markerek, amelyek a szív általános állapo-tával mutatnak szoros összefüggést, mint például az NTproBNP [12]. A rizikóbecslés további pontosítása érde-kében meg kell ismernünk a háttérben zajló patológiai folyamatokat.…”

Uric acid predicts mortality and ischaemic stroke in subjects with diastolic dysfunction: the Tromsø Study 1994–2013

“…In a previous population-based cohort study, we showed that increased UA was associated with elevated risk for all-cause mortality and ischaemic stroke after 15 and 12 years of follow-up, respectively. 6 In a metaanalysis, hyperuricaemia was associated with high all-cause mortality in HF patients. 7 Furthermore, a recent study demonstrated that hyperuricaemia was associated with increased all-cause mortality in patients who were hospitalised for HFpEF.…”

Usefulness of the uric acid and CHA2DS2-VASc score in prediction of left atrial thrombosis in patients with mitral stenosis and sinus rhythm

“…Whether or not gout is present, elevated SUA level is associated with cardiovascular diseases such as hypertension [14], coronary heart disease [19][20][21], AF [24,26], and stroke [22,23]. Previous studies have suggested that this correlation could be due to endothelial dysfunction, local oxidant generation, elevated vascular smooth cell proliferation, and reduced vascular nitric oxide production induced by SUA [28][29][30].…”

“…Similarly [28][29][30], in the present study, a positive correlation between SUA and hs-CRP was also detected. Several studies have detected a correlation between SUA and ischemic stroke [22,23,25]. Studies have suggested that SUA may have harmful effects on platelet function [40] and it may cause endothelial dysfunction [41], thereby explaining the relationship.…”

“…Serum uric acid (SUA), which is the final product of purine metabolism, has been associated with the pathophysiology of several diseases, including hypertension [14], chronic kidney disease [15], congestive heart failure [16], metabolic syndrome [17], type 2 diabetes mellitus [18], atherosclerosis with or without cardiovascular events [19][20][21], and stroke [22][23]. In addition, a correlation was recently detected between hyperuricemia and the development of new-onset AF and increased risk of ischemic stroke in patients with AF [24][25][26][27].…”