Uric acid increases IL-1β secretion and Caspase-1 activation in PBMCs of Behçet’s disease patients: The in vitro immunomodulatory effect of xanthine oxidase inhibitor Allopurinol

Chekaoui, Arezki; Belguendouz, Houda; Lahmar, Karima; Mazari, Fettoum; Terahi, Malika; Hakem, D.; Youinou, Pierre; Touil-Boukoffa, Chafia

doi:10.1016/j.intimp.2019.106119

Cited by 3 publications

(1 citation statement)

References 51 publications

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“…However, in our opinion, this phenomenon should be further discussed. As it was already mentioned, UA is systematically released from damaged cells to form urate crystals, which are recognized by immune system cells that secrete interleukin-1 [37]. This typical proinflammatory cytokine initiates an endovascular inflammatory process leading primarily to endothelial failure, a process that finally may lead to atherosclerosis.…”

Section: Discussionmentioning

confidence: 96%

Association of Oral Status and Early Primary Hypertension Biomarkers among Children and Adolescents

Paszyńska

Dmitrzak‐Węglarz

Ostalska‐Nowicka

et al. 2020

IJERPH

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The aim of this case–control study was the evaluation of the association between biomarkers of early primary arterial hypertension (HA) and oral diseases among children and adolescents. Material and methods. Subjects suspected of primary HA (n = 180) underwent a complex evaluation of their vascular status: blood pressure, heart rate, vascular stiffness, sympathetic activity in a 24 h ambulatory examination, followed by measurement of serum uric acid (UA), cystatin C, and creatinine. This procedure allowed the identification of children with primary (n = 58) and secondary HA (n = 74), as well as of children with normal arterial blood pressure, who served as a control group (n = 48). All subjects with secondary HA were excluded from further investigation. Oral examination included the measurement of caries intensity (using the decayed, missing, filled index for permanent teeth DMFT /primary teeth dmft), bacterial plaque (by the plaque control record index, PCR%), and gingivitis (by the bleeding on probing index, BOP%). For statistical analysis, a linear regression model and Spearman rank correlation were used. Results. UA, cystatin C, and creatinine were not altered in the HA group. However, the number of decayed permanent teeth (DT) and the DMFT, PCR%, and BOP% indexes were significantly higher in the primary HA group compared to the control group (p = 0.0006; p = 0.02; p = 0.0009; p = 0.003). Our results are not sufficient to prove the important role of caries and gingival inflammation in the modulation of HA symptoms, although they prove the association of oral diseases with primary HA symptoms. This may indicate future strategies for preventive measures for hypertensive children and adolescents.

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Section: Discussionmentioning

confidence: 96%

Association of Oral Status and Early Primary Hypertension Biomarkers among Children and Adolescents

Paszyńska

Dmitrzak‐Węglarz

Ostalska‐Nowicka

et al. 2020

IJERPH

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Interleukin-1 family in Behçet’s disease: Inflammatory and antiinflammatory mediators

Hamzaoui¹,

Hamzaoui²

2023

Translational Autoimmunity

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The roles of immune cells in Behçet’s disease

Hu,

Guan

2023

Adv Rheumatol

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Behçet’s disease (BD) is a systemic vasculitis that can affect multiple systems, including the skin, mucous membranes, joints, eyes, gastrointestinal and nervous. However, the pathogenesis of BD remains unclear, and it is believed that immune-inflammatory reactions play a crucial role in its development. Immune cells are a critical component of this process and contribute to the onset and progression of BD. By regulating the function of these immune cells, effective control over the occurrence and development of BD can be achieved, particularly with regards to monocyte activation and aggregation, macrophage differentiation and polarization, as well as T cell subset differentiation. This review provides a brief overview of immune cells and their role in regulating BD progression, which may serve as a theoretical foundation for preventing and treating this disease.

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Uric acid increases IL-1β secretion and Caspase-1 activation in PBMCs of Behçet’s disease patients: The in vitro immunomodulatory effect of xanthine oxidase inhibitor Allopurinol

Cited by 3 publications

References 51 publications

Association of Oral Status and Early Primary Hypertension Biomarkers among Children and Adolescents

Association of Oral Status and Early Primary Hypertension Biomarkers among Children and Adolescents

Interleukin-1 family in Behçet’s disease: Inflammatory and antiinflammatory mediators

The roles of immune cells in Behçet’s disease

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