Uric acid in chronic coronary syndromes: Relationship with coronary artery disease severity and left ventricular diastolic parameter

Maloberti, Alessandro; Bossi, Irene; Tassistro, Elena; Rebora, Paola; Racioppi, Angelo; Nava, Stefano; Soriano, Francesco; Piccaluga, Emanuela; Piccalò, Giacomo; Oreglia, Jacopo; Vallerio, Paola; Pirola, Roberto; Chiara, Benedetta De; Oliva, Fabrizio; Moreo, Antonella; Valsecchi, Maria Grazia; Giannattasio, Cristina

doi:10.1016/j.numecd.2021.01.023

Cited by 23 publications

(11 citation statements)

References 41 publications

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“…Hyperuricemia represents an epidemiological problem, especially if CV comorbidities are present. Its prevalence ranges from 6% in healthy subjects [ 9 ] to 14% in hypertensives [ 10 ], with a significant increase to 23% among patients with ACS and Chronic Coronary Syndrome (CCS) [ 11 , 12 ]. After a brief introduction on UA’s general role in CV events, this review focuses on UA’s relationship with CV outcomes, as well as on specific features of patients with ACS and CCS.…”

Section: Introductionmentioning

confidence: 99%

The Role of Uric Acid in Acute and Chronic Coronary Syndromes

Maloberti

Biolcati

Ruzzenenti

et al. 2021

JCM

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Uric acid (UA) is the final product of the catabolism of endogenous and exogenous purine nucleotides. While its association with articular gout and kidney disease has been known for a long time, new data have demonstrated that UA is also related to cardiovascular (CV) diseases. UA has been identified as a significant determinant of many different outcomes, such as all-cause and CV mortality, and also of CV events (mainly Acute Coronary Syndromes (ACS) and even strokes). Furthermore, UA has been related to the development of Heart Failure, and to a higher mortality in decompensated patients, as well as to the onset of atrial fibrillation. After a brief introduction on the general role of UA in CV disorders, this review will be focused on UA’s relationship with CV outcomes, as well as on the specific features of patients with ACS and Chronic Coronary Syndrome. Finally, two issues which remain open will be discussed: the first is about the identification of a CV UA cut-off value, while the second concerns the possibility that the pharmacological reduction of UA is able to lower the incidence of CV events.

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Section: Introductionmentioning

confidence: 99%

The Role of Uric Acid in Acute and Chronic Coronary Syndromes

Maloberti

Biolcati

Ruzzenenti

et al. 2021

JCM

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“…Open access people. [6][7][8][9] Some observational studies also confirmed that increased SUA levels promote the development of CKD, especially in children and adolescents. 10 11 Although a quite of epidemiological studies have investigated the risk factors of HUA or increased SUA in general people or elderly even children, few studies focuse on these relationship among women under different years old.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 86%

Prevalence and related factors of hyperuricaemia in Shanghai adult women of different ages: a multicentre and cross-sectional study

Tao

et al. 2021

BMJ Open

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ObjectiveWomen in different age phases have different metabolism and hormone levels that influence the production and excretion of uric acid. We aimed to investigate the prevalence and related factors of hyperuricaemia among women in various age phases.Study designObservational, cross-sectional study.SettingData were obtained from women at three health check-up centres in Shanghai.ParticipantsAdult women from three health check-up centres were recruited. Exclusion criteria were individuals with pregnancy, cancer, incomplete information. Finally, 11 601 participants were enrolled.ResultsThe prevalence rates of hyperuricaemia of total subjects were 11.15% (95% CIs 10.57% to 11.72%). The prevalence of hyperuricaemia in 18–29, 30–39, 40–49, 50–59, 60–69 and ≥70 years old was 6.41% (95% CI 4.97% to 7.86%), 5.63% (4.71% to 6.55%), 6.02% (5.01%% to 7.03%), 11.51% (10.19% to 12.82%), 16.49% (15.03% to 17.95%) and 23.98% (21.56% to 26.40%), respectively. Compared with 18–29 years old, the ORs for hyperuricaemia in other age phases were 0.870 (95% CI 0.647 to 1.170, p=0.357), 0.935 (0.693 to 1.261, p=0.659), 1.898 (1.444 to 2.493, p<0.001), 2.882 (2.216 to 3.748, p<0.001) and 4.602 (3.497 to 6.056, p<0.001), respectively. During the 18–29 years old, the related factors for hyperuricaemia were obesity and dyslipidaemia. During the 30–59 years old, the related factors were obesity, dyslipidaemia, hypertension and chronic kidney disease (CKD). Over the 60 years old, the occurrence of hyperuricaemia was mainly affected by obesity, dyslipidaemia and CKD, while hypertension cannot be an impact factor for hyperuricaemia independently of obesity and dyslipidaemia.ConclusionAfter 50 years old, the prevalence of hyperuricaemia in Shanghai women has increased significantly and reaches the peak after 70. Obesity and dyslipidaemia are two main related factors for hyperuricaemia during all ages, while diabetes mellitus and nephrolithiasis have no relationship with hyperuricaemia throughout. CKD is an independent impact factor for hyperuricaemia after 30 years old.

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“…In line with our hypothesis, in an observational study including 231 patients with chronic coronary syndrome and complete SUA data, Maloberti et al concluded that the adverse impact of SUA may gradually be overshadowed by other risk factors when coronary disease evolved to more advanced stages. 32 Qin et al reported that as the increases in the quartiles of SUA, the prevalence of CVD elevated only in those without metabolism syndrome (p for trend <0.001), but not necessarily increased in those with metabolism syndrome (p for trend = 0.217). 33 Our exploratory analysis where the whole cohort was stratified by HEART score also corroborated this hypothesis, since the protective value of uric acid gradually became evident with the increases in the HEART score.…”

Section: Discussionmentioning

confidence: 99%