Abstract:Serum uric acid is associated with cIMT in asymptomatic prepubertal children. Both higher BMI and preperitoneal fat aggravate the potential risk of atherosclerotic disease imposed by higher concentrations of uric acid.
“…Figure 4 shows that the mean cIMT was thicker in each age group compared to younger groups, and this difference was significant between some age groups. These findings are in accordance with other studies [ 16 , 17 , 20 – 22 ]. Fig.…”
Section: Discussionsupporting
confidence: 94%
“…We found a significant difference in cIMTs between men and women, and the cIMT was thicker in men. Our results are consistent with other studies [ 16 , 17 , 20 ]; however, sex does not independently predict the cIMT as confirmed by other studies [ 20 ]. On the other hand, we found a robust correlation between age and the cIMT, as it remained significant after controlling for other factors.…”
BackgroundThe carotid intima media thickness (cIMT) and carotid plaque score (cPS) are respective markers of early and late stage subclinical atherosclerosis. Relationships between some laboratory parameters and subclinical atherosclerosis are not yet clear in community dwelling individuals and non-diabetic subjects, so we try to elucidate these relationships and find a model to predict early and late stage subclinical atherosclerosis.MethodsWe examined relationships of the cIMT and cPS with different laboratory and demographic data of 331 subjects from a community-based prospective cohort study, using univariate and multivariate analyses.ResultsIn regression models and after multiple adjustments, only systolic blood pressure (SBP), age, glycated hemoglobin (HBA1c), and waist circumference (WC) were determinants of the cIMT, and only age, SBP, HBA1c, and blood urea nitrogen (BUN) were determinants of a cPS of > 2 in all individuals. Only HBA1c lost its association with regard to predicting the cIMT in non-diabetic subjects.ConclusionsHBA1c at > 5.9% can determine early and late stage subclinical atherosclerosis in community dwelling individuals, but only late stage subclinical atherosclerosis in non-diabetic subjects.
“…Figure 4 shows that the mean cIMT was thicker in each age group compared to younger groups, and this difference was significant between some age groups. These findings are in accordance with other studies [ 16 , 17 , 20 – 22 ]. Fig.…”
Section: Discussionsupporting
confidence: 94%
“…We found a significant difference in cIMTs between men and women, and the cIMT was thicker in men. Our results are consistent with other studies [ 16 , 17 , 20 ]; however, sex does not independently predict the cIMT as confirmed by other studies [ 20 ]. On the other hand, we found a robust correlation between age and the cIMT, as it remained significant after controlling for other factors.…”
BackgroundThe carotid intima media thickness (cIMT) and carotid plaque score (cPS) are respective markers of early and late stage subclinical atherosclerosis. Relationships between some laboratory parameters and subclinical atherosclerosis are not yet clear in community dwelling individuals and non-diabetic subjects, so we try to elucidate these relationships and find a model to predict early and late stage subclinical atherosclerosis.MethodsWe examined relationships of the cIMT and cPS with different laboratory and demographic data of 331 subjects from a community-based prospective cohort study, using univariate and multivariate analyses.ResultsIn regression models and after multiple adjustments, only systolic blood pressure (SBP), age, glycated hemoglobin (HBA1c), and waist circumference (WC) were determinants of the cIMT, and only age, SBP, HBA1c, and blood urea nitrogen (BUN) were determinants of a cPS of > 2 in all individuals. Only HBA1c lost its association with regard to predicting the cIMT in non-diabetic subjects.ConclusionsHBA1c at > 5.9% can determine early and late stage subclinical atherosclerosis in community dwelling individuals, but only late stage subclinical atherosclerosis in non-diabetic subjects.
“…The authors observed such an association between SUA and MetS also in children that they concluded hyperuricemia should be yet considered in early childhood as CVD risk factor [7]. Very recently Bassols et al [14] found increased serum uric acid is associated with cIMT in asymptomatic prepubertal children highlighting the role of uric acid levels in the shaping of the cardiometabolic risk very early in childhood.…”
BackgroundTo investigate the association of serum uric acid (SUA) with cardiometabolic abnormalities in Caucasian overweight/obese children (<10 years of age) versus adolescents (≥10 years of age) by drawing age and gender specific percentiles of uric acid.MethodsCross-sectional evaluation of 1364 Caucasian overweight/obese patients (age 4.1–17.9 years; 726 males, 53%; 560 children, 41%).ResultsSUA levels were significantly lower in children than in adolescents (4.74 ± 1.05 vs. 5.52 ± 1.49 mg/dl, p < 0.001) and peaked in 12–14 years-old boys and 10–12 years-old girls.In children with levels of SUA in the highest quartile (N = 75, 13%), OR for high triglycerides was 4.145, 95% CI 1.506–11.407 (p = 0.009). In adolescents with SUA in the highest quartile (N = 274, 34%), ORs for insulin resistance was 2.399 (95%CI 1.4–4.113; p < 0.001); for impaired fasting glucose 2.184 (95% CI 0.877–5.441; p = 0.07); for impaired glucose tolerance 2.390 (95% CI 1.405–4.063; p = 0.001); and for high triglycerides 1.8, (95%CI 0.950–3.420; p = 0.05). Multivariable random-effect linear regression models demonstrated that waist circumference and age (p < 0.0001 for both) are the variables most significantly predicting SUA levels, followed by triglycerides (p = 0.005) and 2 h glucose (p = 0.03) while HOMA-IR and BMI z-score did not predict SUA.ConclusionsHigh uric acid is associated with metabolic abnormalities and particularly with waist circumference very early in childhood.
“…We have noted hyperuricemia associates with an increased risk of fractures in elderly community-dwelling adults [ 17 ] and with coronary calcification in patients with type 1 diabetes mellitus [ 18 ]. Other groups have published similar findings associating asymptomatic hyperuricemia with coronary calcification [ 19 , 20 ] and with CIMT [ 21 , 22 ]. Based on these data, we hypothesized that lowering serum uric acid levels would improve CKD-MBD parameters and slow vascular calcification in patients with CKD.…”
BackgroundChronic kidney disease (CKD)-mineral and bone disorder (MBD) is a systemic disorder that leads to vascular calcification and accelerated atherosclerosis. Uric acid has been shown to associate with vascular calcification and with carotid intima-media thickness (CIMT) and to suppress the 1 α-hydroxylase enzyme leading to lower 1,25-dihydroxyvitamin D (1,25(OH)2D) and higher intact parathyroid hormone (iPTH) levels. We hypothesized that lowering serum uric acid would reduce CIMT, calcification propensity, and circulating markers of CKD-MBD in CKD.MethodsThis is a post-hoc analysis of a randomized, double-blind study of 80 patients with stage 3 CKD and hyperuricemia who received allopurinol or placebo for 12 weeks. CIMT and T50 were measured as markers of vascular disease and serum calcification propensity, respectively. The following markers of CKD-MBD were measured: serum calcium, phosphorus, vitamin D metabolites, iPTH, and fibroblast growth factor-23 (FGF-23). Expression of extra-renal 1α-hydroxylase was evaluated in endothelial cells of study participants.FindingsAllopurinol successfully lowered serum uric acid levels compared to placebo with an estimate of -3.3 mg/dL (95% C.I. -4.1,-2.5; p < 0.0001). After 12 weeks, however, we found no significant change in CIMT or serum T50. There was not a significant change in vitamin D metabolites, iPTH, FGF-23, or the expression of endothelial 1α-hydroxylase.ConclusionThese data suggest that factors other than uric acid may play a more important role in the regulation of CKD- MBD including vascular calcification and vitamin D metabolism in patients with CKD.
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