Uric acid associated with acute heart failure presentation in Acute Coronary Syndrome patients

Rebora, Paola; Centola, Marco; Morici, Nuccia; Sacco, Alice; Occhino, Giuseppe; Viola, Giovanna; Oreglia, Jacopo; Castini, Diego; Persampieri, Simone; Sabatelli, Ludovico; Ferrante, Giulia; Lucreziotti, Stefano; Carugo, Stefano; Valsecchi, Maria Grazia; Oliva, Fabrizio; Giannattasio, Cristina; Maloberti, Alessandro

doi:10.1016/j.ejim.2022.01.018

Cited by 22 publications

(14 citation statements)

References 29 publications

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“…Previous studies have shown that uric acid is important in inflammation and is associated with mortality in ACS patients. 33,34 However, our study observed no correlation between uric acid and TRS-2P. This might have been due to the small sample size and sampling errors.…”

Section: Discussioncontrasting

confidence: 64%

NLRP3 Inflammasome May Be a Biomarker for Risk Stratification in Patients with Acute Coronary Syndrome

Mo¹,

Wang²,

Han³

et al. 2022

JIR

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Purpose Acute coronary syndrome (ACS) has a high incidence and mortality rate worldwide, which has a considerable negative impact on the global economy. This study aimed to identify a group of ACS patients at a high risk of recurrent adverse cardiac events using the plasma NLRP3 inflammasome. Patients and methods ACS patients admitted to Liaocheng People’s Hospital between June 2021 and March 2022 were enrolled in this study. Patients were divided into low (levels < 3.84 ng/mL) and high (levels ≥ 3.84 ng/mL) groups based on the median NLRP3 inflammasome levels. The patients were divided into three groups according to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention (TRS-2P): low (scores ≤ 2 points), intermediate (scores = 3 points), and high (score ≥ 4 points) risk. We investigated the relationship between NLRP3 inflammasome and laboratory indicators. Additionally, we examined whether the NLRP3 inflammasome was an independent predictor of high TRS-2P and explored the applicability of the plasma NLRP3 inflammasome for predicting high TRS-2P. Results Logistic regression analysis revealed that NLRP3 inflammasome was an independent predictor of high TRS-2P (odds ratio [OR]:2.013; 95% confidence interval [CI]: 1.174–3.452). The area under the receiver operating characteristic curve value of the NLRP3 inflammasome was 0.674 (95% CI: 0.611–0.737; P < 0.001). Conclusion NLRP3 inflammasome levels are an independent predictive factor for high TRS-2P levels, which indicates that the NLRP3 inflammasome may help predict the prognosis of ACS patients.

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Section: Discussioncontrasting

confidence: 64%

NLRP3 Inflammasome May Be a Biomarker for Risk Stratification in Patients with Acute Coronary Syndrome

Mo¹,

Wang²,

Han³

et al. 2022

JIR

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“…However, hyperuricemia has been linked to an increased risk of 2 and 5 year all-cause mortality in STEMI patients following PCI [ 198 , 199 ], with the best cut-off value for UA to predict MACEs in young patients with NSTEMI being >5.2 [ 200 ]. Specifically, a number of studies discovered a connection between UA levels at admission and particular HF-related problems, such as the Killip class, the use of an intra-aortic balloon pump and cardiogenic shock, LV ejection fraction at admission, and the use of non-invasive ventilation [ 201 , 202 ]. Furthermore, with regard to STEMI patients, the plasma level of uric acid at admission continues to be a good indicator of impaired coronary blood flow after the first PCI [ 203 ].…”

Section: Resultsmentioning

confidence: 99%

From Classic to Modern Prognostic Biomarkers in Patients with Acute Myocardial Infarction

Stătescu

Anghel

Tudurachi

et al. 2022

IJMS

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Despite all the important advances in its diagnosis and treatment, acute myocardial infarction (AMI) is still one of the most prominent causes of morbidity and mortality worldwide. Early identification of patients at high risk of poor outcomes through the measurement of various biomarker concentrations might contribute to more accurate risk stratification and help to guide more individualized therapeutic strategies, thus improving prognoses. The aim of this article is to provide an overview of the role and applications of cardiac biomarkers in risk stratification and prognostic assessment for patients with myocardial infarction. Although there is no ideal biomarker that can provide prognostic information for risk assessment in patients with AMI, the results obtained in recent years are promising. Several novel biomarkers related to the pathophysiological processes found in patients with myocardial infarction, such as inflammation, neurohormonal activation, myocardial stress, myocardial necrosis, cardiac remodeling and vasoactive processes, have been identified; they may bring additional value for AMI prognosis when included in multi-biomarker strategies. Furthermore, the use of artificial intelligence algorithms for risk stratification and prognostic assessment in these patients may have an extremely important role in improving outcomes.

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“…Hyperuricemia is an epidemiological problem, especially if present in association with cardiovascular comorbidities ( 11 ). Among patients with acute coronary syndrome (ACS) and chronic coronary syndrome (CCS), patients with hyperuricemia increase significantly to 23% ( 12 – 14 ). The proportion of patients with hyperuricemia in our study (22.2%) was similar to them.…”

Section: Discussionmentioning

confidence: 99%

Sex differences between serum uric acid levels and cardiovascular outcomes in patients with coronary artery disease after stent implantation

Yuan

Kim²,

Lee³

et al. 2023

Front. Cardiovasc. Med.

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BackgroundThe relationship between elevated serum uric acid (SUA) levels and cardiovascular outcomes after stent implantation remains uncertain. This study sought to evaluate the impact of SUA on 12-month cardiovascular outcomes after stent implantation.MethodsWe performed a retrospective study of patients who successfully underwent stent implantation and enrolled 3,222 patients with coronary artery disease (CAD) from a single center. SUA levels were measured before stent implantation. The patients were divided into six groups (<4, 4–4.9, 5–5.9, 6–6.9, 7–7.9 and ≥ 8 mg/dL) at SUA intervals of 1.0 mg/dL. The incidence of cardiovascular outcomes in the six groups was monitored for 1 year after stent implantation and the hazard ratios were estimated. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) for cardiovascular outcomes were estimated using a Cox proportional hazard regression analysis. The primary endpoint was all-cause death. The secondary endpoint was a composite of all-cause death, myocardial infarction, target vessel revascularization, stent thrombosis and stroke. The follow-up duration was 12 months.ResultsOver the 12-month follow-up period, there were 101 all-cause deaths and 218 MACCE. After adjustment for several parameters, the group with SUA levels of more than or equal to 8 mg/dL had significantly higher hazard ratios in the incidence of all-cause death or MACCE. The group with <4.0 mg/dL had significantly higher hazard ratios in all-cause death only in male patients. In contrast, there were no significant differences observed for cardiovascular outcomes in female patients.ConclusionsOur study identified a U-shaped association between SUA levels and cardiovascular outcomes during 12-month follow-up for males, but not for females. Further studies are warranted to clarify the sex differences between SUA levels and clinical outcomes.

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Uric acid associated with acute heart failure presentation in Acute Coronary Syndrome patients

Cited by 22 publications

References 29 publications

NLRP3 Inflammasome May Be a Biomarker for Risk Stratification in Patients with Acute Coronary Syndrome

NLRP3 Inflammasome May Be a Biomarker for Risk Stratification in Patients with Acute Coronary Syndrome

From Classic to Modern Prognostic Biomarkers in Patients with Acute Myocardial Infarction

Sex differences between serum uric acid levels and cardiovascular outcomes in patients with coronary artery disease after stent implantation

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