Uric acid and uric acid/creatinine ratio and their correlations with the hemorheological determinants in subjects with subclinical carotid atherosclerosis

Abstract

BACKGROUND AND OBJECTIVE: we have examined the concentration of serum uric acid and the serum uric acid/creatinine ratio as well as their correlations with the main determinants of the hemorheological profile in a group of subjects with subclinical carotid atherosclerosis. METHODS: we evaluated the concentration of serum uric acid and the serum uric acid/creatine ratio in 43 men and 57 women [median age 66.00 (25)] with subclinical carotid atherosclerosis, subsequently divided according to the number of traditional cardiovascular risk factors and to the insulin resistance degree. RESULTS: serum uric acid, but not the serum uric acid/creatinine ratio, results strongly influenced by the number of cardiovascular risk factors and by the insulin resistance degree. In the whole group and in the subgroups of subclinical carotid atherosclerosis subjects, serum uric acid and serum uric acid/creatinine ratio show significant correlation, besides with whole blood viscosity, with plasma viscosity and erythrocyte aggregation. The influence of the serum uric acid on the erythrocyte aggregability that is a part of the erythrocyte aggregation is to ascribe to the action carried out by serum uric acid on the erythrocyte zeta potential. CONCLUSIONS: it is reasonable to think that the treatment of the asymptomatic or symptomatic hyperuricemia with the urate-lowering therapy that reduces the serum uric acid concentration may reflect on the hemorheological profile which role on the atherosclerotic cardiovascular disease is well known.

Serum Uric Acid to Serum Creatinine Ratio and Risk of Stroke Recurrence in Young Adults with Ischemic Stroke

“…40 Physicians should also pay attention to patients with high SUA/SCr values, while uric acid is normal and employs protective strategies such as serum uratelowering and renal protection therapies. 41 Additionally, we found that diabetes mellitus, hypertension, antiplatelet drug usage at discharge, and smoking status were associated with stroke recurrence in young adults. Sarecka-Hujar et al conducted a literature review and found that hypertension and diabetes mellitus were more prevalent in young patients with recurrent stroke.…”

“… 40 Physicians should also pay attention to patients with high SUA/SCr values, while uric acid is normal and employs protective strategies such as serum urate-lowering and renal protection therapies. 41 …”

Effect and mechanism of Yiqing decoction on hyperuricemia rats

“…Other components of Yiqingfang, such as naringenin and diosgenin, can reduce the expression of HIF-1 and VEG-FA, decrease lipid synthesis and inflammatory response, and enhance the level of autophagy [13,14]. According to the "renal overload" theory [15], the intestinal tract plays a key role in the homeostatic regulation of blood uric acid levels, and abnormalities in intestinal and renal function firstly lead to a sustained increase in uric acid levels, which in turn triggers a vicious cycle of tissue damage and uric acid accumulation in the body [16].…”