Uric acid and survival in chronic heart failure: Validation and application in metabolic, functional, and hemodynamic staging

The burden of chronic obstructive pulmonary disease in patients hospitalized with heart failure

“…Uric acid may reflect body catabolism and the disturbed catabolic/anabolic balance that frequently occurs in advanced stages of disease, also suggested by higher furosemide use. It remained predictive for all-cause mortality even after adjustment, which fits well previous findings in patients with CHF [14]. The reluctance to use beta-blockers in patients with CHF and COPD is another important finding whose importance can hardly be overestimated.…”

Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate

“…Finally, we mention again the relative lack of impact of diuretics (figure 4e, f) on our biomarkers relative to their apparent effect on creatinine (figure 5f). Uric acid has been suggested as a marker of cardiovascular mortality and its level is known to increase in patients with heart failure (Leyva et al, 1998a, b;Anker et al, 2003Sakai et al, 2006, albeit not, it is claimed, when adjusted for diuretic use (Culleton et al, 1999b). It is probably a measure of impaired oxidative capacity (Leyva et al, 1997, b) and it is of interest that it too was observed as being among the most significant biomarkers in our metabolomics data (figure 2, Table 2).…”

Plasma Uric Acid as a Prognostic Marker in Patients With Hypertrophic Cardiomyopathy

“…Recent studies suggest that uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation and vasoconstriction. 4 A number of studies showed that UA is an independent risk factor for adverse outcomes of various cardiovascular disease, 5-7 including heart failure, [8][9][10] ischemic stroke, 7,10,11 myocardial infarction, 10, 11 hypertension, 12, 13 and atrial fibrillation. 14 However, the significan of UA in the prognosis of HCM remains to be evaluated.…”